메뉴 건너뛰기




Volumn 4, Issue 11, 2009, Pages 1177-1189

Building a drugtarget network and its applications

Author keywords

Drug disease network; Drug target network; Network analysis; Network integration; Target identification

Indexed keywords

IMATINIB; NONSTEROID ANTIINFLAMMATORY AGENT;

EID: 72949115326     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460440903322234     Document Type: Review
Times cited : (32)

References (90)
  • 1
    • 41149096945 scopus 로고    scopus 로고
    • Bork P. Large-scale prediction of drug-target relationships
    • Kuhn M, Campillos M, Gonzalez P, et al. Bork P. Large-scale prediction of drug-target relationships. FEBS Lett 2008;582(8):1283-1290
    • (2008) FEBS Lett , vol.582 , Issue.8 , pp. 1283-1290
    • Kuhn, M.1    Campillos, M.2    Gonzalez, P.3
  • 3
    • 46249090791 scopus 로고    scopus 로고
    • Prediction of drug-target interaction networks from the integration of chemical and genomic spaces
    • Yamanishi Y, Araki M, Gutteridge A, et al. Prediction of drug-target interaction networks from the integration of chemical and genomic spaces. Bioinformatics 2008;24(13):I232-I40
    • (2008) Bioinformatics , vol.24 , Issue.13
    • Yamanishi, Y.1    Araki, M.2    Gutteridge, A.3
  • 4
    • 67249095008 scopus 로고    scopus 로고
    • Alignment-free prediction of a drug-target complex network based on parameters of drug connectivity and protein sequence of receptors
    • Vina D, Uriarte E, Orallo F, et al. Alignment-free prediction of a drug-target complex network based on parameters of drug connectivity and protein sequence of receptors. Molecular Pharmaceutics 2009;6(3):825-835
    • (2009) Molecular Pharmaceutics , vol.6 , Issue.3 , pp. 825-835
    • Vina, D.1    Uriarte, E.2    Orallo, F.3
  • 5
    • 54249155522 scopus 로고    scopus 로고
    • Network pharmacology: The next paradigm in drug discovery
    • Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 2008;4(11):682-690
    • (2008) Nat Chem Biol , vol.4 , Issue.11 , pp. 682-690
    • Hopkins, A.L.1
  • 7
    • 47249146126 scopus 로고    scopus 로고
    • Drug target identification using side-effect similarity
    • Campillos M, Kuhn M, Gavin AC, et al. Drug target identification using side-effect similarity. Science 2008;321(5886):263-266
    • (2008) Science , vol.321 , Issue.5886 , pp. 263-266
    • Campillos, M.1    Kuhn, M.2    Gavin, A.C.3
  • 8
    • 58749107670 scopus 로고    scopus 로고
    • Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks
    • Prado-Prado FJ, De La Vega OM, Uriarte E, et al. Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks. Bioorgan Med Chem 2009;17(2):569-575
    • (2009) Bioorgan Med Chem , vol.17 , Issue.2 , pp. 569-575
    • Prado-Prado, F.J.1    De La Vega, O.M.2    Uriarte, E.3
  • 9
    • 39049100511 scopus 로고    scopus 로고
    • Unified QSAR and network-based computational chemistry approach to antimicrobials, PART 1: Multispecies activity models for antifungals
    • Gonzalez-Diaz H, Prado-Prado FJ. Unified QSAR and network-based computational chemistry approach to antimicrobials, part 1: Multispecies activity models for antifungals. J Comput Chem 2008;29(4):656-667
    • (2008) J Comput Chem , vol.29 , Issue.4 , pp. 656-667
    • Gonzalez-Diaz, H.1    Prado-Prado, F.J.2
  • 10
    • 67849104638 scopus 로고    scopus 로고
    • PubChem: A public information system for analyzing bioactivities of small molecules
    • Web Server issue
    • Wang Y, Xiao J, Suzek TO, et al. PubChem: a public information system for analyzing bioactivities of small molecules. Nucleic Acids Res 2009;37(Web Server issue):W623-33
    • (2009) Nucleic Acids Res , vol.37
    • Wang, Y.1    Xiao, J.2    Suzek, T.O.3
  • 11
    • 38549151817 scopus 로고    scopus 로고
    • DrugBank: A knowledgebase for drugs, drug actions and drug targets
    • (Database issue)
    • Wishart DS, Knox C, Guo AC, et al. DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res 2008;36(Database issue):D901-6
    • (2008) Nucleic Acids Res , vol.36
    • Wishart, D.S.1    Knox, C.2    Guo, A.C.3
  • 12
    • 38549121773 scopus 로고    scopus 로고
    • ChemBank: A small-molecule screening and cheminformatics resource database
    • (Database issue)
    • Seiler KP, George GA, Happ MP, et al. ChemBank: a small-molecule screening and cheminformatics resource database. Nucleic Acids Res 2008;36(Database issue):D351-9
    • (2008) Nucleic Acids Res , vol.36
    • Seiler, K.P.1    George, G.A.2    Happ, M.P.3
  • 13
    • 33644874819 scopus 로고    scopus 로고
    • From genomics to chemical genomics: New developments in KEGG
    • Database issue
    • Kanehisa M, Goto S, Hattori M, et al. From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res 2006;34(Database issue):D354-7
    • (2006) Nucleic Acids Res , vol.34
    • Kanehisa, M.1    Goto, S.2    Hattori, M.3
  • 15
    • 0037255072 scopus 로고    scopus 로고
    • The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003
    • Boeckmann B, Bairoch A, Apweiler R, et al. The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003. Nucleic Acids Res 2003;31(1):365-370
    • (2003) Nucleic Acids Res , vol.31 , Issue.1 , pp. 365-370
    • Boeckmann, B.1    Bairoch, A.2    Apweiler, R.3
  • 16
    • 0036084258 scopus 로고    scopus 로고
    • TTD: Therapeutic target database
    • Chen X, Ji ZL, Chen YZ. TTD: therapeutic target database. Nucleic Acids Res 2002;30(1):412-415
    • (2002) Nucleic Acids Res , vol.30 , Issue.1 , pp. 412-415
    • Chen, X.1    Ji, Z.L.2    Chen, Y.Z.3
  • 17
    • 8844222708 scopus 로고    scopus 로고
    • TargetDB: A target registration database for structural genomics projects
    • Chen L, Oughtred R, Berman HM, Westbrook J. TargetDB: a target registration database for structural genomics projects. Bioinformatics 2004;20(16):2860-2862
    • (2004) Bioinformatics , vol.20 , Issue.16 , pp. 2860-2862
    • Chen, L.1    Oughtred, R.2    Berman, H.M.3    Westbrook, J.4
  • 18
    • 40549130652 scopus 로고    scopus 로고
    • PDTD: A web-accessible protein database for drug target identification
    • Gao Z, Li H, Zhang H, et al. PDTD: a web-accessible protein database for drug target identification. BMC Bioinformatics 2008;9:104
    • (2008) BMC Bioinformatics , vol.9 , pp. 104
    • Gao, Z.1    Li, H.2    Zhang, H.3
  • 19
    • 38549182474 scopus 로고    scopus 로고
    • SuperTarget and matador: Resources for exploring drug-target relationships
    • Database issue
    • Gunther S, Kuhn M, Dunkel M, et al. SuperTarget and matador: resources for exploring drug-target relationships. Nucleic Acids Res 2008;36(Database issue):D919-22
    • (2008) Nucleic Acids Res , vol.36
    • Gunther, S.1    Kuhn, M.2    Dunkel, M.3
  • 20
    • 33947658874 scopus 로고    scopus 로고
    • The reactive metabolite target protein database (TPDB)-a web-accessible resource
    • Hanzlik RP, Koen YM, Theertham B, et al. The reactive metabolite target protein database (TPDB)-a web-accessible resource. BMC Bioinformatics 2007;8:95
    • (2007) BMC Bioinformatics , vol.8 , pp. 95
    • Hanzlik, R.P.1    Koen, Y.M.2    Theertham, B.3
  • 21
    • 34547844087 scopus 로고    scopus 로고
    • DITOP: Drug-induced toxicity related protein database
    • Zhang JX, Huang WJ, Zeng JH, et al. DITOP: drug-induced toxicity related protein database. Bioinformatics 2007;23(13):1710-1712
    • (2007) Bioinformatics , vol.23 , Issue.13 , pp. 1710-1712
    • Zhang, J.X.1    Huang, W.J.2    Zeng, J.H.3
  • 22
    • 0042122711 scopus 로고    scopus 로고
    • Drug adverse reaction target database (DART): Proteins related to adverse drug reactions
    • Ji ZL, Han LY, Yap CW, et al. Drug Adverse Reaction Target Database (DART): proteins related to adverse drug reactions. Drug Saf 2003;26(10):685-690
    • (2003) Drug Saf , vol.26 , Issue.10 , pp. 685-690
    • Ji, Z.L.1    Han, L.Y.2    Yap, C.W.3
  • 24
    • 33749335282 scopus 로고    scopus 로고
    • The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease
    • Lamb J, Crawford ED, Peck D, et al. The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006;313(5795):1929-1935
    • (2006) Science , vol.313 , Issue.5795 , pp. 1929-1935
    • Lamb, J.1    Crawford, E.D.2    Peck, D.3
  • 25
    • 0036081355 scopus 로고    scopus 로고
    • Gene expression omnibus: NCBI gene expression and hybridization array data repository
    • Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002;30(1):207-210
    • (2002) Nucleic Acids Res , vol.30 , Issue.1 , pp. 207-210
    • Edgar, R.1    Domrachev, M.2    Lash, A.E.3
  • 26
    • 33846039701 scopus 로고    scopus 로고
    • ArrayExpress-a public database of microarray experiments and gene expression profiles
    • Database issue
    • Parkinson H, Kapushesky M, Shojatalab M, et al. ArrayExpress-a public database of microarray experiments and gene expression profiles. Nucleic Acids Res 2007;35(Database issue):D747-50
    • (2007) Nucleic Acids Res , vol.35
    • Parkinson, H.1    Kapushesky, M.2    Shojatalab, M.3
  • 28
    • 33749011163 scopus 로고    scopus 로고
    • The NCI60 human tumour cell line anticancer drug screen
    • Shoemaker RH. The NCI60 human tumour cell line anticancer drug screen. Nat Rev Cancer 2006;6(10):813-823
    • (2006) Nat Rev Cancer , vol.6 , Issue.10 , pp. 813-823
    • Shoemaker, R.H.1
  • 30
    • 38549130733 scopus 로고    scopus 로고
    • STITCH: Interaction networks of chemicals and proteins
    • Database issue
    • Kuhn M, Mering C, Campillos M, et al. STITCH: interaction networks of chemicals and proteins. Nucleic Acids Res 2008;36(Database issue):D684-8
    • (2008) Nucleic Acids Res , vol.36
    • Kuhn, M.1    Mering, C.2    Campillos, M.3
  • 31
    • 72949098506 scopus 로고    scopus 로고
    • NIMH. NIMH
    • NIMH. http://pdsp.med.unc.edu. NIMH
  • 32
    • 33846108633 scopus 로고    scopus 로고
    • BindingDB: A web-accessible database of experimentally determined protein-ligand binding affinities
    • Database issue
    • Liu T, Lin Y, Wen X, et al. BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities. Nucleic Acids Res 2007;35(Database issue):D198-201
    • (2007) Nucleic Acids Res , vol.35
    • Liu, T.1    Lin, Y.2    Wen, X.3
  • 34
    • 33644877904 scopus 로고    scopus 로고
    • MetaCyc: A multiorganism database of metabolic pathways and enzymes
    • Database issue
    • Caspi R, Foerster H, Fulcher CA, et al. MetaCyc: a multiorganism database of metabolic pathways and enzymes. Nucleic Acids Res 2006;34(Database issue):D511-6
    • (2006) Nucleic Acids Res , vol.34
    • Caspi, R.1    Foerster, H.2    Fulcher, C.A.3
  • 36
    • 33846876695 scopus 로고    scopus 로고
    • Relating protein pharmacology by ligand chemistry
    • Keiser MJ, Roth BL, Armbruster BN, et al. Relating protein pharmacology by ligand chemistry. Nat Biotechnol 2007;25(2):197-206
    • (2007) Nat Biotechnol , vol.25 , Issue.2 , pp. 197-206
    • Keiser, M.J.1    Roth, B.L.2    Armbruster, B.N.3
  • 37
    • 67349205019 scopus 로고    scopus 로고
    • A chemogenomic approach to drug discovery: Focus on cardiovascular diseases
    • Cases M, Mestres J. A chemogenomic approach to drug discovery: focus on cardiovascular diseases. Drug Discov Today 2009;14(9-10):479-485
    • (2009) Drug Discov Today , vol.14 , Issue.9-10 , pp. 479-485
    • Cases, M.1    Mestres, J.2
  • 38
    • 34548128437 scopus 로고    scopus 로고
    • Statistical prediction of protein chemical interactions based on chemical structure and mass spectrometry data
    • Nagamine N, Sakakibara Y. Statistical prediction of protein chemical interactions based on chemical structure and mass spectrometry data. Bioinformatics 2007;23(15):2004-2012
    • (2007) Bioinformatics , vol.23 , Issue.15 , pp. 2004-2012
    • Nagamine, N.1    Sakakibara, Y.2
  • 39
    • 67650895854 scopus 로고    scopus 로고
    • Integrating statistical predictions and experimental verifications for enhancing protein-chemical interaction predictions in virtual screening
    • Nagamine N, Shirakawa T, Minato Y, et al. Integrating statistical predictions and experimental verifications for enhancing protein-chemical interaction predictions in virtual screening. PLoS Comput Biol 2009;5(6):e1000397
    • (2009) PLoS Comput Biol , vol.5 , Issue.6
    • Nagamine, N.1    Shirakawa, T.2    Minato, Y.3
  • 40
    • 67049100457 scopus 로고    scopus 로고
    • Drug Discovery using chemical systems biology: Identification of the protein-ligand binding network to explain the side effects of CETP Inhibitors
    • Xie L, Li J, Xie L, Bourne PE. Drug Discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP Inhibitors. PLoS Comput Biol 2009;5(5):e1000387
    • (2009) PLoS Comput Biol , vol.5 , Issue.5
    • Xie, L.1    Li, J.2    Xie, L.3    Bourne, P.E.4
  • 41
    • 48449090136 scopus 로고    scopus 로고
    • SuperPred: Drug classification and target prediction
    • Web Server issue
    • Dunkel M, Gunther S, Ahmed J, et al. SuperPred: drug classification and target prediction. Nucleic Acids Res 2008;36(Web Server issue):W55-9
    • (2008) Nucleic Acids Res , vol.36
    • Dunkel, M.1    Gunther, S.2    Ahmed, J.3
  • 42
    • 36349010717 scopus 로고    scopus 로고
    • Prediction of potential drug targets based on simple sequence properties
    • Li Q, Lai L. Prediction of potential drug targets based on simple sequence properties. BMC Bioinformatics 2007;8:353
    • (2007) BMC Bioinformatics , vol.8 , pp. 353
    • Li, Q.1    Lai, L.2
  • 43
    • 42349096647 scopus 로고    scopus 로고
    • A global view of drug-therapy interactions
    • Nacher JC, Schwartz JM. A global view of drug-therapy interactions. BMC Pharmacol 2008;8:5
    • (2008) BMC Pharmacol , vol.8 , pp. 5
    • Nacher, J.C.1    Schwartz, J.M.2
  • 44
    • 58149242456 scopus 로고    scopus 로고
    • An experimentally derived confidence score for binary protein-protein interactions
    • Braun P, Tasan M, Dreze M, et al. An experimentally derived confidence score for binary protein-protein interactions. Nat Methods 2009;6(1):91-98
    • (2009) Nat Methods , vol.6 , Issue.1 , pp. 91-98
    • Braun, P.1    Tasan, M.2    Dreze, M.3
  • 45
    • 33644656793 scopus 로고    scopus 로고
    • Systematic identification of functional orthologs based on protein network comparison
    • Bandyopadhyay S, Sharan R, Ideker T. Systematic identification of functional orthologs based on protein network comparison. Genome Res 2006;16(3):428-435
    • (2006) Genome Res , vol.16 , Issue.3 , pp. 428-435
    • Bandyopadhyay, S.1    Sharan, R.2    Ideker, T.3
  • 46
    • 6944240088 scopus 로고    scopus 로고
    • Local graph alignment and motif search in biological networks
    • Berg J, Lassig M. Local graph alignment and motif search in biological networks. Proc Natl Acad Sci USA 2004;101(41):14689-14694
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.41 , pp. 14689-14694
    • Berg, J.1    Lassig, M.2
  • 47
    • 34547840254 scopus 로고    scopus 로고
    • Identification of functional modules from conserved ancestral protein-protein interactions
    • Dutkowski J, Tiuryn J. Identification of functional modules from conserved ancestral protein-protein interactions. Bioinformatics 2007;23(13):I149-I58
    • (2007) Bioinformatics , vol.23 , Issue.13
    • Dutkowski, J.1    Tiuryn, J.2
  • 48
    • 66349124837 scopus 로고    scopus 로고
    • Domain-oriented edge-based alignment of protein interaction networks
    • Guo X, Hartemink AJ. Domain-oriented edge-based alignment of protein interaction networks. Bioinformatics 2009;25(12):I240-I6
    • (2009) Bioinformatics , vol.25 , Issue.12
    • Guo, X.1    Hartemink, A.J.2
  • 49
    • 0141593601 scopus 로고    scopus 로고
    • Conserved pathways within bacteria and yeast as revealed by global protein network alignment
    • Kelley BP, Sharan R, Karp RM, et al. Conserved pathways within bacteria and yeast as revealed by global protein network alignment. Proc Natl Acad Sci USA 2003;100(20):11394-11399
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.20 , pp. 11394-11399
    • Kelley, B.P.1    Sharan, R.2    Karp, R.M.3
  • 50
    • 63049115956 scopus 로고    scopus 로고
    • Metabolic pathway alignment between species using a comprehensive and flexible similarity measure
    • Li YL, De Ridder D, De Groot MJL, Reinders MJT. Metabolic pathway alignment between species using a comprehensive and flexible similarity measure. Bmc Systems Biology 2008;2:111
    • (2008) Bmc Systems Biology , vol.2 , pp. 111
    • Li, Y.L.1    De Ridder, D.2    De Groot, M.J.L.3    Reinders, M.J.T.4
  • 51
    • 0035211290 scopus 로고    scopus 로고
    • Identification of potential interaction networks using sequence-based searches for conserved protein-protein interactions or "interologs"
    • Matthews LR, Vaglio P, Reboul J, et al. Identification of potential interaction networks using sequence-based searches for conserved protein-protein interactions or "interologs". Genome Res 2001;11(12):2120-2126
    • (2001) Genome Res , vol.11 , Issue.12 , pp. 2120-2126
    • Matthews, L.R.1    Vaglio, P.2    Reboul, J.3
  • 52
    • 0034667776 scopus 로고    scopus 로고
    • A heuristic graph comparison algorithm and its application to detect functionally related enzyme clusters
    • Ogata H, Fujibuchi W, Goto S, Kanehisa M. A heuristic graph comparison algorithm and its application to detect functionally related enzyme clusters. Nucleic Acids Res 2000;28(20):4021-4028
    • (2000) Nucleic Acids Res , vol.28 , Issue.20 , pp. 4021-4028
    • Ogata, H.1    Fujibuchi, W.2    Goto, S.3    Kanehisa, M.4
  • 53
    • 33645732240 scopus 로고    scopus 로고
    • Modeling cellular machinery through biological network comparison
    • Sharan R, Ideker T. Modeling cellular machinery through biological network comparison. Nat Biotechnol 2006;24(4):427-433
    • (2006) Nat Biotechnol , vol.24 , Issue.4 , pp. 427-433
    • Sharan, R.1    Ideker, T.2
  • 54
    • 13844314048 scopus 로고    scopus 로고
    • Conserved patterns of protein interaction in multiple species
    • Sharan R, Suthram S, Kelley RM, et al. Conserved patterns of protein interaction in multiple species. Proc Natl Acad Sci USA 2005;102(6):1974-1979
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.6 , pp. 1974-1979
    • Sharan, R.1    Suthram, S.2    Kelley, R.M.3
  • 55
    • 0141993704 scopus 로고    scopus 로고
    • A gene-coexpression network for global discovery of conserved genetic modules
    • Stuart JM, Segal E, Koller D, Kim SK. A gene-coexpression network for global discovery of conserved genetic modules. Science 2003;302(5643):249-255
    • (2003) Science , vol.302 , Issue.5643 , pp. 249-255
    • Stuart, J.M.1    Segal, E.2    Koller, D.3    Kim, S.K.4
  • 56
    • 3042569597 scopus 로고    scopus 로고
    • Annotation transfer between genomes: Protein-protein interologs and protein-DNA regulogs
    • Yu HY, Luscombe NM, Lu HX, et al. Annotation transfer between genomes: protein-protein interologs and protein-DNA regulogs. Genome Res 2004;14(6):1107-1118
    • (2004) Genome Res , vol.14 , Issue.6 , pp. 1107-1118
    • Yu, H.Y.1    Luscombe, N.M.2    Lu, H.X.3
  • 57
    • 33644656793 scopus 로고    scopus 로고
    • Systematic identification of functional orthologs based on protein network comparison
    • Bandyopadhyay S, Sharan R, Ideker T. Systematic identification of functional orthologs based on protein network comparison. Genome Res 2006;16(3):428-435
    • (2006) Genome Res , vol.16 , Issue.3 , pp. 428-435
    • Bandyopadhyay, S.1    Sharan, R.2    Ideker, T.3
  • 58
    • 14844305006 scopus 로고    scopus 로고
    • An efficient algorithm for detecting frequent subgraphs in biological networks
    • Koyuturk M, Grama A, Szpankowski W. An efficient algorithm for detecting frequent subgraphs in biological networks. Bioinformatics 2004;20(Suppl 1):i200-7
    • (2004) Bioinformatics , vol.20 , Issue.SUPPL 1
    • Koyuturk, M.1    Grama, A.2    Szpankowski, W.3
  • 59
    • 27144443099 scopus 로고    scopus 로고
    • Playing dirty
    • Frantz S. Playing dirty. Nature 2005;437(7061):942-943
    • (2005) Nature , vol.437 , Issue.7061 , pp. 942-943
    • Frantz, S.1
  • 60
    • 4644271084 scopus 로고    scopus 로고
    • Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia
    • Roth BL, Sheffler DJ, Kroeze WK. Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nat Rev Drug Discov 2004;3(4):353-359
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.4 , pp. 353-359
    • Roth, B.L.1    Sheffler, D.J.2    Kroeze, W.K.3
  • 61
    • 15044349115 scopus 로고    scopus 로고
    • The efficiency of multi-target drugs: The network approach might help drug design
    • Csermely P, Agoston V, Pongor S. The efficiency of multi-target drugs: the network approach might help drug design. Trends Pharmacol Sci 2005;26(4):178-182
    • (2005) Trends Pharmacol Sci , vol.26 , Issue.4 , pp. 178-182
    • Csermely, P.1    Agoston, V.2    Pongor, S.3
  • 62
    • 30344479953 scopus 로고    scopus 로고
    • The benefits of the multi-target approach in drug design and discovery
    • Espinoza-Fonseca LM. The benefits of the multi-target approach in drug design and discovery. Bioorg Med Chem 2006;14(4):896-897
    • (2006) Bioorg Med Chem , vol.14 , Issue.4 , pp. 896-897
    • Espinoza-Fonseca, L.M.1
  • 63
    • 3242802116 scopus 로고    scopus 로고
    • "Promiscuous" anticancer drugs that hit multiple targets may thwart resistance
    • Hampton T. "Promiscuous" anticancer drugs that hit multiple targets may thwart resistance. Jama-J Am Med Assoc 2004;292(4):419
    • (2004) Jama-J Am Med Assoc , vol.292 , Issue.4 , pp. 419
    • Hampton, T.1
  • 65
    • 27544446579 scopus 로고    scopus 로고
    • Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)
    • Mencher SK, Wang LG. Promiscuous drugs compared to selective drugs (promiscuity can be a virtue). BMC Clin Pharmacol 2005;5(1):3
    • (2005) BMC Clin Pharmacol , vol.5 , Issue.1 , pp. 3
    • Mencher, S.K.1    Wang, L.G.2
  • 66
    • 3242794178 scopus 로고    scopus 로고
    • From magic bullets to designed multiple ligands
    • Morphy R, Kay C, Rankovic Z. From magic bullets to designed multiple ligands. Drug Discov Today 2004;9(15):641-651
    • (2004) Drug Discov Today , vol.9 , Issue.15 , pp. 641-651
    • Morphy, R.1    Kay, C.2    Rankovic, Z.3
  • 67
    • 70349334679 scopus 로고    scopus 로고
    • Predicting the multi-modal binding propensity of small molecules: Towards an understanding of drug promiscuity
    • Park K, Lee S, Ahn HS, Kim D. Predicting the multi-modal binding propensity of small molecules: towards an understanding of drug promiscuity. Mol Biosyst 2009;5(8):844-853
    • (2009) Mol Biosyst , vol.5 , Issue.8 , pp. 844-853
    • Park, K.1    Lee, S.2    Ahn, H.S.3    Kim, D.4
  • 68
    • 4644289587 scopus 로고    scopus 로고
    • Multitargeted drugs: The end of the "one-target-one-disease" philosophy?
    • Wermuth CG. Multitargeted drugs: the end of the "one-target-one- disease" philosophy? Drug Discov Today 2004;9(19):826-827
    • (2004) Drug Discov Today , vol.9 , Issue.19 , pp. 826-827
    • Wermuth, C.G.1
  • 69
    • 34047202181 scopus 로고    scopus 로고
    • Deciphering protein-protein interactions. PART I. Experimental techniques and databases
    • Shoemaker BA, Panchenko AR. Deciphering protein-protein interactions. Part I. Experimental techniques and databases. PLoS Comput Biol 2007;3(3):e42
    • (2007) PLoS Comput Biol , vol.3 , Issue.3
    • Shoemaker, B.A.1    Panchenko, A.R.2
  • 70
    • 59149089414 scopus 로고    scopus 로고
    • Joint evolutionary trees: A large-scale method to predict protein interfaces based on sequence sampling
    • Engelen S, Trojan LA, Sacquin-Mora S, et al. Joint evolutionary trees: a large-scale method to predict protein interfaces based on sequence sampling. PLoS Comput Biol 2009;5(1)
    • (2009) PLoS Comput Biol , vol.5 , Issue.1
    • Engelen, S.1    Trojan, L.A.2    Sacquin-Mora, S.3
  • 71
    • 34247586171 scopus 로고    scopus 로고
    • Deciphering protein-protein interactions. PART II. Computational methods to predict protein and domain interaction partners
    • Shoemaker BA, Panchenko AR. Deciphering protein-protein interactions. Part II. Computational methods to predict protein and domain interaction partners. PLoS Comput Biol 2007;3(4):e43
    • (2007) PLoS Comput Biol , vol.3 , Issue.4
    • Shoemaker, B.A.1    Panchenko, A.R.2
  • 72
    • 33845762340 scopus 로고    scopus 로고
    • Multi-target therapeutics: When the whole is greater than the sum of the parts
    • Zimmermann GR, Lehar J, Keith CT. Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today 2007;12(1-2):34-42
    • (2007) Drug Discov Today , vol.12 , Issue.1-2 , pp. 34-42
    • Zimmermann, G.R.1    Lehar, J.2    Keith, C.T.3
  • 74
    • 33645396484 scopus 로고    scopus 로고
    • Functional classification of drugs by properties of their pairwise interactions
    • Yeh P, Tschumi AI, Kishony R. Functional classification of drugs by properties of their pairwise interactions. Nat Genet 2006;38(4):489-494
    • (2006) Nat Genet , vol.38 , Issue.4 , pp. 489-494
    • Yeh, P.1    Tschumi, A.I.2    Kishony, R.3
  • 75
    • 33847643207 scopus 로고    scopus 로고
    • Chemical combination effects predict connectivity in biological systems
    • Lehar J, Zimmermann GR, Krueger AS, et al. Chemical combination effects predict connectivity in biological systems. Mol Sys Biol 2007;3:80
    • (2007) Mol Sys Biol , vol.3 , pp. 80
    • Lehar, J.1    Zimmermann, G.R.2    Krueger, A.S.3
  • 76
    • 67650488269 scopus 로고    scopus 로고
    • Synergistic drug combinations tend to improve therapeutically relevant selectivity (vol 7 pg 659 2009)
    • Lehar J, Krueger AS, Avery W, et al. Synergistic drug combinations tend to improve therapeutically relevant selectivity (vol 7, pg 659, 2009). Nat Biotechnol 2009;27(7):1
    • (2009) Nat Biotechnol , vol.27 , Issue.7 , pp. 1
    • Lehar, J.1    Krueger, A.S.2    Avery, W.3
  • 77
    • 0038610570 scopus 로고    scopus 로고
    • Systematic discovery of multicomponent therapeutics
    • Borisy AA, Elliott PJ, Hurst NW, et al. Systematic discovery of multicomponent therapeutics. Proc Natl Acad Sci USA 2003;100(13):7977-7982
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.13 , pp. 7977-7982
    • Borisy, A.A.1    Elliott, P.J.2    Hurst, N.W.3
  • 79
    • 14644403608 scopus 로고    scopus 로고
    • A mathematical model of combination therapy using the EGFR signaling network
    • Araujo RP, Petricoin EF, Liotta LA. A mathematical model of combination therapy using the EGFR signaling network. Biosystems 2005;80(1):57-69
    • (2005) Biosystems , vol.80 , Issue.1 , pp. 57-69
    • Araujo, R.P.1    Petricoin, E.F.2    Liotta, L.A.3
  • 80
    • 37249026328 scopus 로고    scopus 로고
    • Integrating high-content screening and ligand-target prediction to identify mechanism of action
    • Young DW, Bender A, Hoyt J, et al. Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol 2008;4(1):59-68
    • (2008) Nat Chem Biol , vol.4 , Issue.1 , pp. 59-68
    • Young, D.W.1    Bender, A.2    Hoyt, J.3
  • 81
    • 27144509163 scopus 로고    scopus 로고
    • A network-based analysis of systemic inflammation in humans
    • Calvano SE, Xiao W, Richards DR, et al. A network-based analysis of systemic inflammation in humans. Nature 2005;437(7061):1032-1037
    • (2005) Nature , vol.437 , Issue.7061 , pp. 1032-1037
    • Calvano, S.E.1    Xiao, W.2    Richards, D.R.3
  • 82
    • 1542357674 scopus 로고    scopus 로고
    • Revealing modularity and organization in the yeast molecular network by integrated analysis of highly heterogeneous genomewide data
    • Tanay A, Sharan R, Kupiec M, Shamir R. Revealing modularity and organization in the yeast molecular network by integrated analysis of highly heterogeneous genomewide data. Proc Natl Acad Sci USA 2004;101(9):2981-2986
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.9 , pp. 2981-2986
    • Tanay, A.1    Sharan, R.2    Kupiec, M.3    Shamir, R.4
  • 83
    • 33747620519 scopus 로고    scopus 로고
    • Systems biology and combination therapy in the quest for clinical efficacy
    • Fitzgerald JB, Schoeberl B, Nielsen UB, Sorger PK. Systems biology and combination therapy in the quest for clinical efficacy. Nat Chem Biol 2006;2(9):458-466
    • (2006) Nat Chem Biol , vol.2 , Issue.9 , pp. 458-466
    • Fitzgerald, J.B.1    Schoeberl, B.2    Nielsen, U.B.3    Sorger, P.K.4
  • 84
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: Identifying and developing new uses for existing drugs
    • Ashburn TT, Thor KB. Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov 2004;3(8):673-683
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.8 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 85
    • 55449101983 scopus 로고    scopus 로고
    • Organization of physical interactomes as uncovered by network schemas
    • Banks E, Nabieva E, Chazelle B, Singh M. Organization of physical interactomes as uncovered by network schemas. PLoS Comput Biol 2008;4(10)
    • (2008) PLoS Comput Biol , vol.4 , Issue.10
    • Banks, E.1    Nabieva, E.2    Chazelle, B.3    Singh, M.4
  • 86
    • 25444448797 scopus 로고    scopus 로고
    • Spontaneous evolution of modularity and network motifs
    • Kashtan N, Alon U. Spontaneous evolution of modularity and network motifs. Proc Natl Acad Sci USA 2005;102(39):13773-13778
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.39 , pp. 13773-13778
    • Kashtan, N.1    Alon, U.2
  • 87
    • 0037199968 scopus 로고    scopus 로고
    • Hierarchical organization of modularity in metabolic networks
    • Ravasz E, Somera AL, Mongru DA, et al. Hierarchical organization of modularity in metabolic networks. Science 2002;297(5586):1551-1555
    • (2002) Science , vol.297 , Issue.5586 , pp. 1551-1555
    • Ravasz, E.1    Somera, A.L.2    Mongru, D.A.3
  • 89
    • 50949089899 scopus 로고    scopus 로고
    • Inference of protein complex activities from chemical-genetic profile and its applications: Predicting drug-target pathways
    • Han S, Kim D. Inference of protein complex activities from chemical-genetic profile and its applications: predicting drug-target pathways. PLoS Comput Biol 2008;4(8):e1000162
    • (2008) PLoS Comput Biol , vol.4 , Issue.8
    • Han, S.1    Kim, D.2
  • 90
    • 34250330777 scopus 로고    scopus 로고
    • What is a gene, post-ENCODE? History and updated definition
    • Gerstein MB, Bruce C, Rozowsky JS, et al. What is a gene, post-ENCODE? History and updated definition. Genome Res 2007;17(6):669-681
    • (2007) Genome Res , vol.17 , Issue.6 , pp. 669-681
    • Gerstein, M.B.1    Bruce, C.2    Rozowsky, J.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.