Drag reducing polymers improve coronary flow reserve through modulation of capillary resistance

Biorheology

Volumn 46, Issue 5, 2009, Pages 365-378

  Pacella, John J ^a   Kameneva, Marina V ^a,b   Villanueva, Flordeliza S ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b MCGOWAN INSTITUTE FOR REGENERATIVE MEDICINE   (United States)

Author keywords

Capillaries; Coronary disease; Drag reducing polymers; Echocardiography; Imaging; Microcirculation

Indexed keywords

DRAG REDUCING POLYMER; POLYMER; UNCLASSIFIED DRUG;

ACUTE CORONARY SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD RHEOLOGY; CAPILLARY RESISTANCE; CONTRAST ECHOCARDIOGRAPHY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY OBSTRUCTION; CORONARY FLOW RESERVE; HEART MUSCLE PERFUSION; HYPEREMIA; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MATHEMATICAL MODEL; NONHUMAN; VASCULAR RESISTANCE;

ANIMALS; BLOOD FLOW VELOCITY; CAPILLARY RESISTANCE; CORONARY CIRCULATION; CORONARY STENOSIS; DISEASE MODELS, ANIMAL; DOGS; HYPEREMIA; MICROCIRCULATION; POLYETHYLENE GLYCOLS;

EID: 72949099897     PISSN: 0006355X     EISSN: None     Source Type: Journal    
DOI: 10.3233/BIR-2009-0548     Document Type: Article

References (37)

1. E.D. Burger, L.G. Chorn and T.K. Perkins, Studies of drag reduction conducted over a broad range of pipeline conditions when flowing Prudhoe Bay crude oil, J. Rheol. 24 (1980), 603.
2. W.M. Chilian, C.L. Eastham and M.L. Marcus, Microvascular distribution of coronary vascular resistance in beating left ventricle, Am. J. Physiol. 251 (1986), H779-H778.
3. W.M. Chilian and M.L. Marcus, Phasic coronary blood flow velocity in intramural and epicardial coronary arteries, Circ. Res. 50 (1982), 775-781.
4. P.B. Coleman, B.T. Ottenbreit and P.I. Polimeni, Effects of a drag-reducing polyelectrolyte of microscopic linear dimension (Separan AP-273) on rat hemodynamics, Circ. Res. 61 (1987), 787-796.
5. M.R. Driels and S. Aryash, Drag reduction in laminar flow, Nature 259 (1976), 389-390.
6. H. Ertepinar, B. Suzen, A. Oxoran, S. Ceylan et al., Effects of drag reducing polymer on atherosclerosis, Biorheology 27 (1990), 631-644.
7. D.K. Glover, L.M. Riou, M. Ruiz, G.W. Sullivan et al., Reduction of infarct size and postischemic inflammation from ATL-146e, a highly selective adenosine A2A receptor agonist, in reperfused canine myocardium, Am. J. Physiol. Heart Circ. Physiol. 288 (2005), H1851-H1858.
8. A.S. Golub, S.S. Grigorian, M.V. Kameneva, N.A. Malkina and K.A. Shoshenko, Influence of polyethylene oxide on the capillary blood flow in diabetic rats, Sov. Physics - Doklady 32 (1987), 620-621.
9. K.L. Gould and L. Lipscomb, Effects of coronary stenoses on coronary flow reserve and resistance, Am. J. Cardiol. 34 (1974), 50.
10. H.L. Greene, R.F Mostardi and R.F. Nokes, Effects of drag-reducing polymers on initiation of atherosclerosis, Polym. Eng. Sci. 20 (1980), 499-504.
11. S.S. Grigorian and M.V. Kameneva, Resistance-reducing polymers in the blood circulation, in: Contemporary Problems of Biomechanics, G.G. Chernyi and S.A. Regirer, eds, Mir Publishers, Moscow, CRC Press, Boca Raton, FL, 1990, pp. 99-110.
12. K.J. Hutchison, J.D. Campbell and E. Karpinski, Decreased poststenotic flow disturbance during drag reduction by polyacrylamide infusion without increased aortic blood flow, Microvasc. Res. 38 (1989), 102-109.
13. J. Jarhult and S. Mellander, Autoregulation of capillary hydrostatic pressure in skeletal muscle during regional arterial hypo-and hypertension, Acta Physiol. Scand. 91 (1974), 32-41.
14. A.R. Jayaweera, K. Wei, M. Coggins, J.P. Bin et al., Role of capillaries in determining CBF reserve: New insights using myocardial contrast echocardiography, Am. J. Physiol. Heart Circ. Physiol. 277 (1999), H2363-H2372.
15. M.V. Kameneva, M.S. Polyakova and E.V. Fedoseeva, Effect of drag-reducing polymers on the structure of the stagnant zones and eddies in models of constricted and branching blood vessels, Fluid Dynamics (FLDYAH) 25 (1990), 956-959.
16. M.V. Kameneva, M.S. Polyakova and I.A. Gvozdkova, Nature of the influence of polymers that lower hydrodynamic resistance on blood circulation, in: Proc. Acad. Sci. USSR Biophys., January-June 1988, pp. 22-24.
17. M.V. Kameneva, Z.J. Wu, A. Uraysh, B. Repko et al., Blood soluble drag-reducing polymers prevent lethality from hemorrhagic shock in acute animal experiments, Biorheology 41 (2004), 53-64.
18. H.H. Lipowsky, S. Kovalcheck and B.W. Zweifach, The distribution of blood rheological parameters in the microvasculature of cat mesentery, Circ. Res. 43 (1978), 738-749.
19. W.D. McComb, Drag-reducing polymers and liquid-column oscillations, Nature 251 (1974), 598-599.
20. G. Mchedlishvili, Disturbed blood flow structuring as critical factor of hemorheological disorders in microcirculation, Clin. Hemorheol. Microcirc. 19 (1998), 315-325.
21. G. Mchedlishvili and N. Maeda, Blood flow structure related to red cell flow: A determinant of blood fluidity in narrow microvessels, Jpn. J. Physiol. 51 (2001), 19-30.
22. S.E. Morgan and C.L. McCormick, Water-soluble copolymers XXXII: Macromolecular drag reduction. A review of predictive theories and the effects of polymer structure, Progr. Polym. Sci. 15 (1990), 507-549.
23. R.A. Mostardi, R.F. Greene and L.C. Thomas, The effect of drag-reducing agents on stenotic flow disturbances in dogs, Biorheology 13 (1976), 137-141.
24. J.J. Pacella,M.V. Kameneva, D. Fischer, E. Lu et al., Drag-reducing polymers decrease arterial vascular resistance without causing vasodilation, J. Am. Coll. Cardiol. 41 (2003), 372A (Abstract).
25. J.J. Pacella,M.V. Kameneva, E. Lu, D. Fischer et al., A novel, hydrodynamic approach for the treatment of coronary artery disease, Eur. Heart J. 27 (2006), 2362-2369.
26. J.J. Pacella, E. Lu, J. Gretton, D. Fischer et al., Drag reduction by polymer infusion: A new mechanism to enhance microcirculatory perfusion for the treatment of ischemia, J. Am. Coll. Cardiol. 43 (2004), 290A (Abstract).
27. P.I. Polimeni and B.T. Ottenbreit, Hemodynamic effects of a Poly(Ethylene Oxide) drag reducing polymer, Polyox WSR N-60K, in the open-chest rat, J. Cardiovasc. Pharmacol. 14 (1989), 374-380.
28. P.I. Polimeni, B.T. Ottenbreit and P.B. Coleman, Enhancement of aortic blood flow with a linear anionic macropolymer of extraordinary molecular length, J. Mol. Cell. Cardiol. 17 (1985), 721-724.
29. B.S. Solov'ev, The effect of drag-reducing polymers on blood, circulation of frogs, in: Mechanics of Biological Continua, Moscow University Press, Moscow, 1986, pp. 89-92.
30. M. Soutani, Y. Suzuki, N. Tateishi and N. Maeda, Quantitative evaluation of flow dynamics of erythrocytes in microvessels: Influence of erythrocyte aggregation, Am. J. Physiol. Heart Circ. Physiol. 268 (1995), H1959-H1965.
31. B.A. Toms, Some observations on the flow of linear polymer solution through straight tubes at large Reynolds numbers, Proc. 1st Int. Congr. Rheol. 2 (1948), 135-141.
32. J.L. Unthank, S.G. Lalka, J.C. Nixon and A.P. Sawchuk, Improvement of flow through arterial stenoses by drag-reducing agents, J. Surg. Res. 53 (1992), 625-630.
33. F.S. Villanueva, E.W. Gertz, M. Csikari, G. Pulido et al., Detection of coronary artery stenosis using power Doppler imaging, Circulation 103 (2001), 2624-2630.
34. K. Wei, A.R. Jayaweera, S. Firoozan, A. Linka et al., Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion, Circulation 97 (1998), 473-483.
35. R.L. Whitmore, Hemorheology and hemodynamics, Biorheology 1 (1963), 201-220.
36. M.P. Wiedeman, Patterns of the arteriovenous pathway, in: Handbook of Physiology, 1963, pp. 891-893 (Chapter 27).
37. B.J. Zweifach, Quantitative studies of microcirculatory structure and function. I. Analysis of pressure distribution in the terminal vascular bed in cat mesentery, Circ. Res. 34 (1974), 843-857.