NSA2, a novel nucleolus protein regulates cell proliferation and cell cycle

Biochemical and Biophysical Research Communications

Volumn 391, Issue 1, 2010, Pages 651-658

  Zhang, Heyu ^a,b   Ma, Xi ^a,b,d   Shi, Taiping ^c   Song, Quansheng ^a,b   Zhao, Hongshan ^a,b   Ma, Dalong ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

^c CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

^d CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Cell cycle; Cell proliferation; NSA2; Nuclear localization signals

Indexed keywords

NOP SEVEN ASSOCIATED 2; NUCLEAR PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; FEMALE; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; NUCLEAR LOCALIZATION SIGNAL; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; CELL NUCLEOLUS; CELL PROLIFERATION; DOWN-REGULATION; G1 PHASE; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR PROTEINS; PHYLOGENY; S PHASE;

EID: 72949090361     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.11.114     Document Type: Article

References (28)

1. Wu X., Ivanova G., Merup M., Jansson M., Stellan B., Grander D., Zabarovsky E., Gahrton G., and Einhorn S. Molecular analysis of the human chromosome 5q13.3 region in patients with hairy cell leukemia and identification of tumor suppressor gene candidates. Genomics 60 (1999) 161-171
2. Stanchi F., Bertocco E., Toppo S., Dioguardi R., Simionati B., Cannata N., Zimbello R., Lanfranchi G., and Valle G. Characterization of 16 novel human genes showing high similarity to yeast sequences. Yeast 18 (2001) 69-80
3. Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.C., Greco A., Hochstrasser D., and Diaz J.J. Functional proteomic analysis of human nucleolus. Mol. Biol. Cell 13 (2002) 4100-4109
4. Andersen J.S., Lam Y.W., Leung A.K., Ong S.E., Lyon C.E., Lamond A.I., and Mann M. Nucleolar proteome dynamics. Nature 433 (2005) 77-83
5. Lebreton A., Saveanu C., Decourty L., Jacquier A., and Fromont-Racine M. Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs. J. Biol. Chem. 281 (2006) 27099-27108
6. Wang J.L., Zhang Y.P., Gu Y.Y., Wang J.X., and Zhao X.F. Function of a TGF-beta inducible nuclear protein in the silk gland in Bombyx mori. Insect. Mol. Biol. 18 (2009) 243-251
7. Moroz L.L., Edwards J.R., Puthanveettil S.V., Kohn A.B., Ha T., Heyland A., Knudsen B., Sahni A., Yu F., Liu L., Jezzini S., Lovell P., Iannucculli W., Chen M., Nguyen T., Sheng H., Shaw R., Kalachikov S., Panchin Y.V., Farmerie W., Russo J.J., Ju J., and Kandel E.R. Neuronal transcriptome of aplysia: neuronal compartments and circuitry. Cell 127 (2006) 1453-1467
8. Ma X., Wang X., Gao X., Wang L., Lu Y., Gao P., Deng W., Yu P., Ma J., Guo J., Cheng H., Zhang C., Shi T., and Ma D. Identification of five human novel genes associated with cell proliferation by cell-based screening from an expressed cDNA ORF library. Life Sci. 81 (2007) 1141-1151
9. Letunic I., Goodstadt L., Dickens N.J., Doerks T., Schultz J., Mott R., Ciccarelli F., Copley R.R., Ponting C.P., and Bork P. Recent improvements to the SMART domain-based sequence annotation resource. Nucleic Acids Res. 30 (2002) 242-244
10. Hinsby A.M., Kiemer L., Karlberg E.O., Lage K., Fausboll A., Juncker A.S., Andersen J.S., Mann M., and Brunak S. A wiring of the human nucleolus. Mol. Cell 22 (2006) 285-295
11. Mayer C., Bierhoff H., and Grummt I. The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev. 19 (2005) 933-941
12. Olson M.O. Sensing cellular stress: another new function for the nucleolus?. Sci. STKE 2004 (2004) 10
13. Timmers A.C., Stuger R., Schaap P.J., van 't Riet J., and Raue H.A. Nuclear and nucleolar localization of Saccharomyces cerevisiae ribosomal proteins S22 and S25. FEBS Lett. 452 (1999) 335-340
14. Rowland R.R., and Yoo D. Nucleolar-cytoplasmic shuttling of PRRSV nucleocapsid protein: a simple case of molecular mimicry or the complex regulation by nuclear import Nucleolar localization and nuclear export signal sequences. Virus Res. 95 (2003) 23-33
15. Catez F., Erard M., Schaerer-Uthurralt N., Kindbeiter K., Madjar J.J., and Diaz J.J. Unique motif for nucleolar retention and nuclear export regulated by phosphorylation. Mol. Cell. Biol. 22 (2002) 1126-1139
16. Sheng Z., Lewis J.A., and Chirico W.J. Nuclear and nucleolar localization of 18-kDa fibroblast growth factor-2 is controlled by C-terminal signals. J. Biol. Chem. 279 (2004) 40153-40160
17. Dingwall C., and Laskey R.A. Nuclear targeting sequences-a consensus?. Trends Biochem. Sci. 16 (1991) 478-481
18. Hahn M.A., and Marsh D.J. Nucleolar localization of parafibromin is mediated by three nucleolar localization signals. FEBS Lett. 581 (2007) 5070-5074
19. Lohrum M.A., Ashcroft M., Kubbutat M.H., and Vousden K.H. Identification of a cryptic nucleolar-localization signal in MDM2. Nat. Cell Biol. 2 (2000) 179-181
20. Weber J.D., Kuo M.L., Bothner B., DiGiammarino E.L., Kriwacki R.W., Roussel M.F., and Sherr C.J. Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex. Mol. Cell. Biol. 20 (2000) 2517-2528
21. Carmo-Fonseca M., Mendes-Soares L., and Campos I. To be or not to be in the nucleolus. Nat. Cell Biol. 2 (2000) E107-E112
22. Comai L. The nucleolus: a paradigm for cell proliferation and aging. Braz. J. Med. Biol. Res. 32 (1999) 1473-1478
23. Du Y.C., and Stillman B. Yph1p an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis. Cell 109 (2002) 835-848
24. Olson M.O., and Dundr M. The moving parts of the nucleolus. Histochem. Cell Biol. 123 (2005) 203-216
25. Olson M.O., Hingorani K., and Szebeni A. Conventional and nonconventional roles of the nucleolus. Int. Rev. Cytol. 219 (2002) 199-266
26. Lempiainen H., and Shore D. Growth control and ribosome biogenesis. Curr. Opin. Cell Biol. (2009)
27. Mayer C., and Grummt I. Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases. Oncogene 25 (2006) 6384-6391
28. Wang H., Zhao L.N., Li K.Z., Ling R., Li X.J., and Wang L. Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer. BMC Cancer 6 (2006) 91