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3
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72849136215
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Alkaloids 1, 2 and 4 have been characterized by single crystal X-ray analysis: (a) Reference 2
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Alkaloids 1, 2 and 4 have been characterized by single crystal X-ray analysis: (a) Reference 2.
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4
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33845889074
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(b) Gan, X.; Bai, H.; Chen, Q.; Ma, L.; Hu, L. Chem. Biodivers. 2006, 3, 1255-1259.
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5
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42649083642
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(c) Tan, C.; Di, Y.; Wang, Y.; Wang, Y.; Mu, S.; Gao, S.; Zhang, Y.; Kong, N.; He, H.; Zhang, J.; Fang, X.; Li, C.; Lu, Y.; Hao, X. Tetrahedron Lett. 2008, 49, 3376-3379.
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7
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72849134798
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For example, daphnipaxinin (3) and oldhamine A (4) were isolated in 0.00024 and 0.00007%, respectively, from their dried plant sources
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For example, daphnipaxinin (3) and oldhamine A (4) were isolated in 0.00024 and 0.00007%, respectively, from their dried plant sources.
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8
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67650493974
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For a recent brief review and leading references, see Overman, L. E. Tetrahedron 2009, 65, 6432-6446.
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Overman, L.E.1
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9
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65249190992
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An enantiocontrolled route to a BCD ring fragment of daphnicyclidin A was described recently, see: Ikeda, S.; Shibuya, M.; Kanoh, N.; Iwabuchi, Y. Org. Lett. 2009, 11, 1833-1836.
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0034600250
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Ahrendt, K. A.; Borths, C. J.; MacMillan, D. W. C. J. Am. Chem. Soc. 2000, 122, 4243-4244.
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72849136476
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Kowalski, M. D. Ph.D. Dissertation, University of California, Irvine, 2008.
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Kowalski, M.D.1
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17644399859
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Biswas, K.; Prieto, O.; Goldsmith, P. J.; Woodward, S. Angew. Chem., Int. Ed. 2005, 44, 2232-2234.
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13
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72849152179
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10 configuration of the major alcohol epimer was confirmed by X-ray analysis of a subsequent product
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10 configuration of the major alcohol epimer was confirmed by X-ray analysis of a subsequent product.
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14
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0346541206
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Minami, I.; Takahashi, K.; Shimizu, I.; Kimura, T.; Tsuji, J. Tetrahedron 1986, 42, 2971-2977.
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17
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72849126039
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A minor amount of a third stereoisomeric adduct that derives from the inseparable minor alcohol epimer of intermediate 13 was also produced
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A minor amount of a third stereoisomeric adduct that derives from the inseparable minor alcohol epimer of intermediate 13 was also produced.
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18
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0034595816
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Cabanal-Duvillard, I.; Berrien, J. F.; Ghosez, L.; Husson, H.-P.; Royer, J. Tetrahedron 2000, 56, 3763-3769.
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(a) Krasovskiy, A.; Kopp, F.; Knochel, P. Angew. Chem., Int. Ed. 2006, 45, 497-500.
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21
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57149084689
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We employed a simpler procedure for preparing this reagent (see Supporting Information); for a related procedure for preparing a cerium acetylide, see: (b) Trost, B. M.; Waser, J.; Meyer, A. J. Am. Chem. Soc. 2008, 130, 16424-16434.
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22
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72849152446
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note
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Aza-Cope-Mannich product 22a was elaborated to a tricyclic pyrrolidinium salt by cleavage of the TBDPS group and intramolecular quaternization by the sequence illustrated in Schemes 4 and 5; see Supporting Information for details. Single crystal X-ray analysis of this derivative confirmed the relative and absolute configuration of 22a. Crystallographic data for this compound were deposited with the Cambridge Crystallographic Data Centre: CCDC 751136.
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23
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0035954898
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For a pertinent example where this reaction also failed to form a seven-membered ring, see: Dudley, G. B.; Danishefsky, S. J. Org. Lett. 2001, 3, 2399-2402.
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