The oncolytic activity of Newcastle disease virus NDV-HUJ on chemoresistant primary melanoma cells is dependent on the proapoptotic activity of the inhibitor of apoptosis protein livin

Journal of Virology

Volumn 84, Issue 1, 2010, Pages 639-646

  Lazar, Itay ^a   Yaacov, Barak ^b   Shiloach, Tamar ^a   Eliahoo, Elad ^b   Kadouri, Luna ^a   Lotem, Michal ^a   Perlman, Riki ^a   Zakay Rones, Zichria ^b   Panet, Amos ^b   Ben Yehuda, Dina ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; INHIBITOR OF APOPTOSIS PROTEIN; LIVIN;

APOPTOSIS; ARTICLE; CARCINOGENESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; MELANOMA; MELANOMA CELL; NEWCASTLE DISEASE PARAMYXOVIRUS; NEWCASTLE DISEASE VIRUS HUJ; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR BIOPSY; VIRUS REPLICATION; VIRUS STRAIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; CASPASES; DRUG RESISTANCE, NEOPLASM; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MELANOMA; NEOPLASM PROTEINS; NEWCASTLE DISEASE VIRUS; ONCOLYTIC VIROTHERAPY; ONCOLYTIC VIRUSES; TUMOR CELLS, CULTURED;

NEWCASTLE DISEASE VIRUS;

EID: 72849135966     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00401-09     Document Type: Article

References (25)

1. Abd-Elrahman, I., K. Hershko, T. Neuman, B. Nachmias, R. Perlman, and D. Ben-Yehuda. 2009. The inhibitor of apoptosis protein Livin (ML-IAP) plays a dual role in tumorigenicity. Cancer Res. 69:5475-5480.
2. Alexander, D. J. 1989. A laboratory manual for the isolation and identification of avian pathogens, 3rd ed., p. 114-120. American Association of Avian Pathologists, Jacksonville, FL.
3. Ashhab, Y., A. Alian, A. Polliack, A. Panet, and D. Ben Yehuda. 2001. Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern. FEBS Lett. 495:56-60. (Pubitemid 32367973)
4. Deveraux, Q. L., E. Leo, H. R. Stennicke, K. Welsh, G. S. Salvesen, and J. C. Reed. 1999. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J. 18:5242-5251.
5. Fabian, Z., C. M. Csatary, J. Szeberenyi, and L. K. Csatary. 2007. p53- independent endoplasmic reticulum stress-mediated cytotoxicity of a Newcastle disease virus strain in tumor cell lines. J. Virol. 81:2817-2830. (Pubitemid 46447045)
6. Fabian, Z., B. Torocsik, K. Kiss, L. K. Csatary, B. Bodey, J. Tigyi, C. Csatary, and J. Szeberenyi. 2001. Induction of apoptosis by a Newcastle disease virus vaccine (MTH-68/H) in PC12 rat phaeochromocytoma cells. Anticancer Res. 21:125-135. (Pubitemid 32267634)
7. Freeman, A. I., Z. Zakay-Rones, J. M. Gomori, E. Linetsky, L. Rasooly, E. Greenbaum, S. Rozenman-Yair, A. Panet, E. Libson, C. S. Irving, E. Galun, and T. Siegal. 2006. Phase I/II trial of intravenous NDV-HUJ oncolytic virus in recurrent glioblastoma multiforme. Mol. Ther. 13:221-228.
8. Helmbach, H., E. Rossmann, M. A. Kern, and D. Schadendorf. 2001. Drug resistance in human melanoma. Int. J. Cancer 93:617-622.
9. Kasof, G. M., and B. C. Gomes. 2001. Livin, a novel inhibitor of apoptosis protein family member. J. Biol. Chem. 276:3238-3246.
10. Krishnamurthy, S., T. Takimoto, R. A. Scroggs, and A. Portner. 2006. Differentially regulated interferon response determines the outcome of Newcastle disease virus infection in normal and tumor cell lines. J. Virol. 80: 5145-5155. (Pubitemid 43752760)
11. Kunicher, N., H. Falk, B. Yaacov, T. Tzur, and A. Panet. 2008. Tropism of lentiviral vectors in skin tissue. Hum. Gene Ther. 19:255-266.
12. Lin, J. H., G. Deng, Q. Huang, and J. Morser. 2000. KIAP, a novel member of the inhibitor of apoptosis protein family. Biochem. Biophys. Res. Commun. 279:820-831.
13. Lorence, R. M., P. A. Rood, and K. W. Kelley. 1988. Newcastle disease virus as an antineoplastic agent: induction of tumor necrosis factor-alpha and augmentation of its cytotoxicity. J. Natl. Cancer Inst. 80:1305-1312.
14. Lotem, M., T. Peretz, O. Drize, Z. Gimmon, D. Ad El, R. Weitzen, H. Goldberg, I. Ben David, D. Prus, T. Hamburger, and E. Shiloni. 2002. Autologous cell vaccine as a post operative adjuvant treatment for high-risk melanoma patients (AJCC stages III and IV). Br. J. Cancer 86:1534-1539. (Pubitemid 34628104)
15. Lotem, M., E. Shiloni, I. Pappo, O. Drize, T. Hamburger, R. Weitzen, R. Isacson, L. Kaduri, S. Merims, S. Frankenburg, and T. Peretz. 2004. Interleukin- 2 improves tumor response to DNP-modified autologous vaccine for the treatment of metastatic malignant melanoma. Br. J. Cancer 90:773-780. (Pubitemid 38406585)
16. Mohammed, M. Q., and S. Retsas. 2000. Oxaliplatin is active in vitro against human melanoma cell lines: comparison with cisplatin and carboplatin. Anticancer Drugs 11:859-863.
17. Nachmias, B., Y. Ashhab, and D. Ben-Yehuda. 2004. The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer. Semin. Cancer Biol. 14:231-243.
18. Nachmias, B., Y. Ashhab, V. Bucholtz, O. Drize, L. Kadouri, M. Lotem, T. Peretz, O. Mandelboim, and D. Ben-Yehuda. 2003. Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanoma. Cancer Res. 63:6340-6349. (Pubitemid 37255182)
19. Nachmias, B., S. Mizrahi, M. Elmalech, I. Lazar, Y. Ashhab, R. Gazit, G. Markel, D. Ben-Yehuda, and O. Mandelboim. 2007. Manipulation of NK cytotoxicity by the IAP family member Livin. Eur. J. Immunol. 37:3467-3476.
20. Parmiani, G., C. Castelli, M. Santinami, and L. Rivoltini. 2007. Melanoma immunology: past, present and future. Curr. Opin. Oncol. 19:121-127.
21. Sinkovics, J. G., and J. C. Horvath. 2000. Newcastle disease virus (NDV): brief history of its oncolytic strains. J. Clin. Virol. 16:1-15.
22. Stegmeier, F., G. Hu, R. J. Rickles, G. J. Hannon, and S. J. Elledge. 2005. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc. Natl. Acad. Sci. USA 102: 13212-13217.
23. Stojdl, D. F., B. Lichty, S. Knowles, R. Marius, H. Atkins, N. Sonenberg, and J. C. Bell. 2000. Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nat. Med. 6:821-825.
24. Vucic, D., H. R. Stennicke, M. T. Pisabarro, G. S. Salvesen, and V. M. Dixit. 2000. ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr. Biol. 10:1359-1366.
25. Yaacov, B., E. Eliahoo, I. Lazar, M. Ben-Shlomo, I. Greenbaum, A. Panet, and Z. Zakay-Rones. 2008. Selective oncolytic effect of an attenuated Newcastle disease virus (NDV-HUJ) in lung tumors. Cancer Gene Ther. 15:795-807.