메뉴 건너뛰기




Volumn 25, Issue 1, 2010, Pages 74-84

A new culture technique that allows in vitro meiotic prophase development of fetal human oocytes

Author keywords

Culture; Meiosis; Oocytes; Recombination; Stem cell factor

Indexed keywords

COLLAGENASE; HYALURONIDASE; STEM CELL FACTOR; TRYPSIN;

EID: 72849122241     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dep351     Document Type: Article
Times cited : (9)

References (49)
  • 1
    • 5044238924 scopus 로고    scopus 로고
    • Expression of stem cell factor and its receptor in human fetal and adult ovaries
    • Abir R, Fisch B, Jin S, Barnnet M, Kessler-Icekson G, Ao A. Expression of stem cell factor and its receptor in human fetal and adult ovaries. Fertil Steril 2004;82(Suppl. 3):1235-1243.
    • (2004) Fertil Steril , vol.82 , Issue.SUPPL. 3 , pp. 1235-1243
    • Abir, R.1    Fisch, B.2    Jin, S.3    Barnnet, M.4    Kessler-Icekson, G.5    Ao, A.6
  • 2
    • 1242297716 scopus 로고    scopus 로고
    • Genetic analysis of Kit ligand functions during mouse spermatogenesis
    • Bedell MA, Mahakali ZA. Genetic analysis of Kit ligand functions during mouse spermatogenesis. J Androl 2004;25:188-199.
    • (2004) J Androl , vol.25 , pp. 188-199
    • Bedell, M.A.1    Mahakali, Z.A.2
  • 4
    • 59849094218 scopus 로고    scopus 로고
    • In vivo and in vitro effects of interleukin-1beta on equine oocyte maturation and on steroidogenesis and prostaglandin synthesis in granulosa and cumulus cells
    • Caillaud M, Gérard N. In vivo and in vitro effects of interleukin-1beta on equine oocyte maturation and on steroidogenesis and prostaglandin synthesis in granulosa and cumulus cells. Reprod Fertil Dev 2009; 21:265-273.
    • (2009) Reprod Fertil Dev , vol.21 , pp. 265-273
    • Caillaud, M.1    Gérard, N.2
  • 5
    • 27344460591 scopus 로고    scopus 로고
    • In vivo effect of interleukin-1beta and interleukin-1RA on oocyte cytoplasmic maturation, ovulation, and early embryonic development in the mare
    • Caillaud M, Duchamp G, Gérard N. In vivo effect of interleukin-1beta and interleukin-1RA on oocyte cytoplasmic maturation, ovulation, and early embryonic development in the mare. Reprod Biol Endocrinol 2005; 22:3-26.
    • (2005) Reprod Biol Endocrinol , vol.22 , pp. 3-26
    • Caillaud, M.1    Duchamp, G.2    Gérard, N.3
  • 6
    • 33646234941 scopus 로고    scopus 로고
    • Kit ligand and c-Kit are expressed during early human ovarian follicular development and their interaction is required for the survival of follicles in long-term culture
    • Carlsson IB, Laitinen MP, Scott JE, Louhio H, Velentzis L, Tuuri T, Aaltonen J, Ritvos O, Winston RM, Hovatta O. Kit ligand and c-Kit are expressed during early human ovarian follicular development and their interaction is required for the survival of follicles in long-term culture. Reproduction 2006;131:641-649.
    • (2006) Reproduction , vol.131 , pp. 641-649
    • Carlsson, I.B.1    Laitinen, M.P.2    Scott, J.E.3    Louhio, H.4    Velentzis, L.5    Tuuri, T.6    Aaltonen, J.7    Ritvos, O.8    Winston, R.M.9    Hovatta, O.10
  • 7
    • 0032858413 scopus 로고    scopus 로고
    • Analysis of a paracentric inversion in human oocytes: Nonhomologous pairing in pachytene
    • Cheng EY, Chen YJ, Disteche CM, Gartler SM. Analysis of a paracentric inversion in human oocytes: nonhomologous pairing in pachytene. Hum Genet 1999;105:191-196.
    • (1999) Hum Genet , vol.105 , pp. 191-196
    • Cheng, E.Y.1    Chen, Y.J.2    Disteche, C.M.3    Gartler, S.M.4
  • 8
    • 56649106342 scopus 로고    scopus 로고
    • Leukemia inhibitory factor induces cumulus expansion in immature human and mouse oocytes and improves mouse two-cell rate and delivery rates when it is present during mouse in vitro oocyte maturation
    • De Matos DG, Miller K, Scott R, Tran CA, Kagan D, Nataraja SG, Clark A, Palmer S. Leukemia inhibitory factor induces cumulus expansion in immature human and mouse oocytes and improves mouse two-cell rate and delivery rates when it is present during mouse in vitro oocyte maturation. Fertil Steril 2008;90:2367-2375.
    • (2008) Fertil Steril , vol.90 , pp. 2367-2375
    • De Matos, D.G.1    Miller, K.2    Scott, R.3    Tran, C.A.4    Kagan, D.5    Nataraja, S.G.6    Clark, A.7    Palmer, S.8
  • 9
    • 0034054123 scopus 로고    scopus 로고
    • Association of mammalian SMC1 and SMC3 proteins with meiotic chromosomes and synaptonemal complex
    • Eijpe M, Heyting C, Gross B, Jessberger R. Association of mammalian SMC1 and SMC3 proteins with meiotic chromosomes and synaptonemal complex. J Cell Sci 2000;113:673-682.
    • (2000) J Cell Sci , vol.113 , pp. 673-682
    • Eijpe, M.1    Heyting, C.2    Gross, B.3    Jessberger, R.4
  • 10
    • 0037416128 scopus 로고    scopus 로고
    • Meiotic cohesin REC8 marks the axial elements of rat synaptonemal complexes before cohesins SMC1 beta and SMC3
    • Eijpe M, Offenberg H, Jessberger R, Revenkova E, Heyting C. Meiotic cohesin REC8 marks the axial elements of rat synaptonemal complexes before cohesins SMC1 beta and SMC3. J Cell Biol 2003; 160:657-670.
    • (2003) J Cell Biol , vol.160 , pp. 657-670
    • Eijpe, M.1    Offenberg, H.2    Jessberger, R.3    Revenkova, E.4    Heyting, C.5
  • 11
    • 0000196186 scopus 로고
    • The fine structure of chromosomes in meiotic prophase of vertebrate spermatocytes
    • Fawcett DW. The fine structure of chromosomes in meiotic prophase of vertebrate spermatocytes. J Biophys Biochem Cytol 1956;2:403-406.
    • (1956) J Biophys Biochem Cytol , vol.2 , pp. 403-406
    • Fawcett, D.W.1
  • 12
    • 0023507253 scopus 로고
    • Development of the first meiotic prophase stages in human fetal oocytes observed by light microscopy
    • Garcia M, Dietrich M, Freixa L, Vink ACG, Ponsa M, Egozcue J. Development of the first meiotic prophase stages in human fetal oocytes observed by light microscopy. Hum Genet 1987;77:223-232.
    • (1987) Hum Genet , vol.77 , pp. 223-232
    • Garcia, M.1    Dietrich, M.2    Freixa, L.3    Vink, A.C.G.4    Ponsa, M.5    Egozcue, J.6
  • 13
    • 34548491797 scopus 로고    scopus 로고
    • Apoptosis in mouse fetal and neonatal oocytes during meiotic prophase one
    • Ghafari F, Gutierrez CG, Hartshorne GM. Apoptosis in mouse fetal and neonatal oocytes during meiotic prophase one. BMC Develop Bio 2008;7:87.
    • (2008) BMC Develop Bio , vol.7 , pp. 87
    • Ghafari, F.1    Gutierrez, C.G.2    Hartshorne, G.M.3
  • 14
    • 0032962153 scopus 로고    scopus 로고
    • Immunocytogenetic detection of normal and abnormal oocytes in human fetal ovarian tissue in culture
    • Hartshorne GM, Barlow AL, Child TJ, Barlow DH, Hulten MA. Immunocytogenetic detection of normal and abnormal oocytes in human fetal ovarian tissue in culture. Hum Reprod 1999;14:172-182.
    • (1999) Hum Reprod , vol.14 , pp. 172-182
    • Hartshorne, G.M.1    Barlow, A.L.2    Child, T.J.3    Barlow, D.H.4    Hulten, M.A.5
  • 15
    • 0029980813 scopus 로고    scopus 로고
    • Synaptonemal complexes: Structure and function
    • Heyting C. Synaptonemal complexes: structure and function. Curr Opin Cell Biol 1996;8:389-396.
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 389-396
    • Heyting, C.1
  • 16
    • 33847236283 scopus 로고    scopus 로고
    • Ovarian dysgerminomas are characterized by frequent KIT mutations and abundant expression of pluripotency markers
    • Hoei-Hansen C, Kraggerud SM, Abeler VM, Kaern J, Rajpert-De Meyts E, Lothe RA. Ovarian dysgerminomas are characterized by frequent KIT mutations and abundant expression of pluripotency markers. Mol Cancer 2007;2:6-12.
    • (2007) Mol Cancer , vol.2 , pp. 6-12
    • Hoei-Hansen, C.1    Kraggerud, S.M.2    Abeler, V.M.3    Kaern, J.4    Rajpert-De Meyts, E.5    Lothe, R.A.6
  • 17
    • 5144234859 scopus 로고    scopus 로고
    • Meiotic recombination intermediates and mismatch repair proteins
    • Hoffmann ER, Borts RH. Meiotic recombination intermediates and mismatch repair proteins. Cytogenet Genome Res 2004;107:232-248.
    • (2004) Cytogenet Genome Res , vol.107 , pp. 232-248
    • Hoffmann, E.R.1    Borts, R.H.2
  • 18
    • 17044405852 scopus 로고    scopus 로고
    • Stem cell factor and c-kit in human primordial germ cells and fetal ovaries
    • Høyer PE, Byskov AG, Møllga°rd K. Stem cell factor and c-kit in human primordial germ cells and fetal ovaries. Mol Cell Endocrinol 2005; 234:1-10.
    • (2005) Mol Cell Endocrinol , vol.234 , pp. 1-10
    • Høyer, P.E.1    Byskov, A.G.2    Møllgard, K.3
  • 19
    • 1542300711 scopus 로고    scopus 로고
    • Effects of follicle size and electrolytes and glucose in maturation medium on nuclear maturation and developmental competence of bovine oocytes
    • Iwata H, Hashimoto S, Ohota M, Kimura K, Shibano K, Miyake M. Effects of follicle size and electrolytes and glucose in maturation medium on nuclear maturation and developmental competence of bovine oocytes. Reproduction 2004;127:159-164.
    • (2004) Reproduction , vol.127 , pp. 159-164
    • Iwata, H.1    Hashimoto, S.2    Ohota, M.3    Kimura, K.4    Shibano, K.5    Miyake, M.6
  • 20
    • 5644302185 scopus 로고    scopus 로고
    • Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination
    • Kolas NK, Cohen PE. Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination. Cytogenet Genome Res 2004;107:216-231.
    • (2004) Cytogenet Genome Res , vol.107 , pp. 216-231
    • Kolas, N.K.1    Cohen, P.E.2
  • 21
    • 11144325648 scopus 로고    scopus 로고
    • Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis i in human oocytes
    • Lenzi ML, Smith J, Snowden T, Kim M, Fishel R, Poulos BK, Cohen PE. Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis I in human oocytes. Am J Hum Genet 2005;76:112-127.
    • (2005) Am J Hum Genet , vol.76 , pp. 112-127
    • Lenzi, M.L.1    Smith, J.2    Snowden, T.3    Kim, M.4    Fishel, R.5    Poulos, B.K.6    Cohen, P.E.7
  • 22
    • 0036797807 scopus 로고    scopus 로고
    • Growth factors promote meiosis in mouse fetal ovaries in vitro
    • Lyrakou S, Hulten MA, Hartshorne GM. Growth factors promote meiosis in mouse fetal ovaries in vitro. Mol Hum Reprod 2002; 8:906-911.
    • (2002) Mol Hum Reprod , vol.8 , pp. 906-911
    • Lyrakou, S.1    Hulten, M.A.2    Hartshorne, G.M.3
  • 23
    • 20044366737 scopus 로고    scopus 로고
    • Effect of serum concentration, method of trypsinization and fusion/activation utilizing transfected fetal cells to generate transgenic dairy goats by somatic cell nuclear transfer
    • Melican D, Butler R, Hawkins N, Chen LH, Hayden E, Destrempes M, Williams J, Lewis T, Behboodi E, Ziomek C et al. Effect of serum concentration, method of trypsinization and fusion/activation utilizing transfected fetal cells to generate transgenic dairy goats by somatic cell nuclear transfer. Thieriogenology 2004;63:1549-1563.
    • (2004) Thieriogenology , vol.63 , pp. 1549-1563
    • Melican, D.1    Butler, R.2    Hawkins, N.3    Chen, L.H.4    Hayden, E.5    Destrempes, M.6    Williams, J.7    Lewis, T.8    Behboodi, E.9    Ziomek, C.10
  • 24
    • 23044480154 scopus 로고    scopus 로고
    • JSAR Outstanding Research Award. in vitro growth of mammalian oocytes
    • Miyano T. JSAR Outstanding Research Award. In vitro growth of mammalian oocytes. J Reprod Dev 2005;51:169-176.
    • (2005) J Reprod Dev , vol.51 , pp. 169-176
    • Miyano, T.1
  • 25
    • 38849090075 scopus 로고    scopus 로고
    • KIT-KIT ligand in the growth of porcine oocytes in primordial follicles
    • Moniruzzaman M, Miyano T. KIT-KIT ligand in the growth of porcine oocytes in primordial follicles. J Reprod Dev 2007;53:1273-1281.
    • (2007) J Reprod Dev , vol.53 , pp. 1273-1281
    • Moniruzzaman, M.1    Miyano, T.2
  • 26
    • 33847394902 scopus 로고    scopus 로고
    • Oocyte growth and follicular development in KIT-deficient Fas-knockout mice
    • Moniruzzaman M, Sakamaki K, Akazawa Y, Miyano T. Oocyte growth and follicular development in KIT-deficient Fas-knockout mice. Reproduction 2007;133:117-125.
    • (2007) Reproduction , vol.133 , pp. 117-125
    • Moniruzzaman, M.1    Sakamaki, K.2    Akazawa, Y.3    Miyano, T.4
  • 27
    • 0017352844 scopus 로고
    • Synaptonemal complex karyotyping in spermatocytes of the Chinese hamster (Cricetulus griseus). I. Morphology of the autosomal complement in spread preparations
    • Moses MJ. Synaptonemal complex karyotyping in spermatocytes of the Chinese hamster (Cricetulus griseus). I. Morphology of the autosomal complement in spread preparations. Chromosoma 1977; 60:99-125.
    • (1977) Chromosoma , vol.60 , pp. 99-125
    • Moses, M.J.1
  • 29
    • 20244380925 scopus 로고    scopus 로고
    • A meiotic chromosomal core consisting of cohesin complex proteins recruits DNA recombination proteins and promotes synapsis in the absence of an axial element in mammalian meiotic cells
    • Pelttari J, Hoja MR, Yuan L, Liu JG, Brundell E, Moens P, Santucci-Darmanin S, Jessberger R, Barbero JL, Heyting C et al. A meiotic chromosomal core consisting of cohesin complex proteins recruits DNA recombination proteins and promotes synapsis in the absence of an axial element in mammalian meiotic cells. Mol Cell Biol 2001;21:5667-5677.
    • (2001) Mol Cell Biol , vol.21 , pp. 5667-5677
    • Pelttari, J.1    Hoja, M.R.2    Yuan, L.3    Liu, J.G.4    Brundell, E.5    Moens, P.6    Santucci-Darmanin, S.7    Jessberger, R.8    Barbero, J.L.9    Heyting, C.10
  • 30
    • 0027205442 scopus 로고
    • Stem cell factor and leukemia inhibitory factor promote primordial germ cell survival by suppressing programmed cell death (apoptosis)
    • Pesce M, Farrace MG, Piacentini M, Dolci S, De Felici M. Stem cell factor and leukemia inhibitory factor promote primordial germ cell survival by suppressing programmed cell death (apoptosis). Development 1993; 118:1089-1094. (Pubitemid 23252399)
    • (1993) Development , vol.118 , Issue.4 , pp. 1089-1094
    • Pesce, M.1    Farrace, M.G.2    Piacentini, M.3    Dolci, S.4    De Felici, M.5
  • 31
    • 0034011069 scopus 로고    scopus 로고
    • STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion
    • Pezzi N, Prieto I, Kremer L, Pérez Jurado LA, Valero C, Del Mazo J, Mart́inez-A C, Barbero JL. STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion. FASEB J 2000;14:581-592.
    • (2000) FASEB J , vol.14 , pp. 581-592
    • Pezzi, N.1    Prieto, I.2    Kremer, L.3    Pérez Jurado, L.A.4    Valero, C.5    Del Mazo, J.6    Mart́inez-A, C.7    Barbero, J.L.8
  • 35
    • 0037766300 scopus 로고    scopus 로고
    • The use of foetal ovarian stromal cell culture for cytogenetic diagnosis. Stromal ovarian culture cytogenetic diagnosis
    • Roig I, Vanrell I, Ortega A, Cabero L, Egozcue J, Garcia M. The use of foetal ovarian stromal cell culture for cytogenetic diagnosis. Stromal ovarian culture cytogenetic diagnosis. Cytotechnology 2003; 41:45-49.
    • (2003) Cytotechnology , vol.41 , pp. 45-49
    • Roig, I.1    Vanrell, I.2    Ortega, A.3    Cabero, L.4    Egozcue, J.5    Garcia, M.6
  • 36
    • 24044519379 scopus 로고    scopus 로고
    • Evolution of the meiotic prophase and of the chromosome pairing process during human fetal ovarian development
    • Roig I, Robles P, Garcia R, Martin M, Egozcue J, Cabero L, Barambio S, Garcia M. Evolution of the meiotic prophase and of the chromosome pairing process during human fetal ovarian development. Hum Reprod 2005;20:2463-2469.
    • (2005) Hum Reprod , vol.20 , pp. 2463-2469
    • Roig, I.1    Robles, P.2    Garcia, R.3    Martin, M.4    Egozcue, J.5    Cabero, L.6    Barambio, S.7    Garcia, M.8
  • 37
    • 33749020818 scopus 로고    scopus 로고
    • Human fetal ovarian culture permits meiotic progression and chromosome pairing process
    • Roig I, Garcia R, Robles P, Cortvrindt R, Egozcue J, Smitz J, Garcia M. Human fetal ovarian culture permits meiotic progression and chromosome pairing process. Hum Reprod 2006;21:1359-1367.
    • (2006) Hum Reprod , vol.21 , pp. 1359-1367
    • Roig, I.1    Garcia, R.2    Robles, P.3    Cortvrindt, R.4    Egozcue, J.5    Smitz, J.6    Garcia, M.7
  • 38
    • 75749083376 scopus 로고    scopus 로고
    • Improvement of in vitro culture of mouse cumulus-oocyte complexes using PDE3-inhibitor followed by meiosis induction with epiregulin
    • doi:10.1016/j.fertnstert. 2008.10.016
    • Romero S, Smitz J. Improvement of in vitro culture of mouse cumulus-oocyte complexes using PDE3-inhibitor followed by meiosis induction with epiregulin. Fertil Steril 2008; doi:10.1016/j.fertnstert. 2008.10.016.
    • (2008) Fertil Steril
    • Romero, S.1    Smitz, J.2
  • 39
    • 54449090464 scopus 로고    scopus 로고
    • Growth differentiation factor-9 and anti-Müllerian hormone expression in cultured human follicles from frozen-thawed ovarian tissue
    • Sadeu JC, Smitz J. Growth differentiation factor-9 and anti-Müllerian hormone expression in cultured human follicles from frozen-thawed ovarian tissue. Reprod Biomed Online 2008;537-548.
    • (2008) Reprod Biomed Online , pp. 537-548
    • Sadeu, J.C.1    Smitz, J.2
  • 40
    • 0036156494 scopus 로고    scopus 로고
    • Possible mechanism for acceleration of meiotic progression of bovine follicular oocytes by growth factors in vitro
    • Sakaguchi M, Dominko T, Yamauchi N, Leibfried-Rutledge ML, Nagai T, First NL. Possible mechanism for acceleration of meiotic progression of bovine follicular oocytes by growth factors in vitro. Reproduction 2000;123:135-142.
    • (2000) Reproduction , vol.123 , pp. 135-142
    • Sakaguchi, M.1    Dominko, T.2    Yamauchi, N.3    Leibfried-Rutledge, M.L.4    Nagai, T.5    First, N.L.6
  • 41
    • 0029025110 scopus 로고
    • The central region of the synaptonemal complex revealed in three dimensions
    • Schmekel K, Daneholt B. The central region of the synaptonemal complex revealed in three dimensions. Trends Cell Biol 1995;5:239-242.
    • (1995) Trends Cell Biol , vol.5 , pp. 239-242
    • Schmekel, K.1    Daneholt, B.2
  • 43
    • 1642379738 scopus 로고    scopus 로고
    • Interaction between the oocytes and surrounding somatic cells in follicular development: Lesson from in vitro culture
    • Senbon S, Hirao Y, Miyano T. Interaction between the oocytes and surrounding somatic cells in follicular development: lesson from in vitro culture. J Reprod Dev 2003;49:259-269.
    • (2003) J Reprod Dev , vol.49 , pp. 259-269
    • Senbon, S.1    Hirao, Y.2    Miyano, T.3
  • 44
    • 33745506647 scopus 로고    scopus 로고
    • Oocyte-granulosa cell interactions during mouse follicular development: Regulation of kit ligand expression and its role in oocyte growth
    • Thomas FH, Vanderhyden BC. Oocyte-granulosa cell interactions during mouse follicular development: regulation of kit ligand expression and its role in oocyte growth. Reprod Biol Endocrinol 2006;12:4-19.
    • (2006) Reprod Biol Endocrinol , vol.12 , pp. 4-19
    • Thomas, F.H.1    Vanderhyden, B.C.2
  • 45
    • 0347287034 scopus 로고    scopus 로고
    • How to make a good oocyte: An update on in vitro models to study follicles regulation
    • Thomas FH, Walters KA, Telfer EE. How to make a good oocyte: an update on in vitro models to study follicles regulation. Hum Reprod Update 2003;9:541-555.
    • (2003) Hum Reprod Update , vol.9 , pp. 541-555
    • Thomas, F.H.1    Walters, K.A.2    Telfer, E.E.3
  • 47
    • 0033167012 scopus 로고    scopus 로고
    • Development to live young from bovine small oocytes after growth, maturation and fertilization in vitro
    • Yamamoto K, Otoi T, Koyama N, Horikita N, Tachikawa S, Miyano T. Development to live young from bovine small oocytes after growth, maturation and fertilization in vitro. Theriogenology 1999;52:81-89.
    • (1999) Theriogenology , vol.52 , pp. 81-89
    • Yamamoto, K.1    Otoi, T.2    Koyama, N.3    Horikita, N.4    Tachikawa, S.5    Miyano, T.6
  • 48
    • 58149198801 scopus 로고    scopus 로고
    • The mammalian synaptonemal complex: A scaffold and beyond
    • Yang F, Wang PJ. The mammalian synaptonemal complex: a scaffold and beyond. Genome Dyn Basel Karger 2009;5:69-80.
    • (2009) Genome Dyn Basel Karger , vol.5 , pp. 69-80
    • Yang, F.1    Wang, P.J.2
  • 49
    • 34250373620 scopus 로고    scopus 로고
    • Chemotherapy-induced thrombocytopenia derives from the selective death of megakaryocyte progenitors and can be rescued by stem cell factor
    • Zeuner A, Signore M, Martinetti D, Bartucci M, Peschle C, De Maria R. Chemotherapy-induced thrombocytopenia derives from the selective death of megakaryocyte progenitors and can be rescued by stem cell factor. Cancer Res 2007;67:4767-4773.
    • (2007) Cancer Res , vol.67 , pp. 4767-4773
    • Zeuner, A.1    Signore, M.2    Martinetti, D.3    Bartucci, M.4    Peschle, C.5    De Maria, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.