Dronedarone: A promising alternative for the management of atrial fibrillation

Cardiovascular Drugs and Therapy

Volumn 23, Issue 5, 2009, Pages 385-393

  Yalta, Kenan ^a   Turgut, Okan Onur ^a   Yılmaz, Mehmet Birhan ^a   YIlmaz, Ahmet ^a   Tandogan, Izzet ^a  

^a CUMHURIYET UNIVERSITY   (Turkey)

Author keywords

Anti arrhythmic safety; Atrial fibrillation; Dronedarone; Rate control; Rhythm control

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; AMIODARONE; ANTIARRHYTHMIC AGENT; ANTICOAGULANT AGENT; CALCIUM CHANNEL L TYPE; CYTOCHROME P450 2D6; DISOPYRAMIDE; DOFETILIDE; DRONEDARONE; DRUG METABOLITE; FLECAINIDE; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; METOPROLOL; N DEBUTYLDRONEDARONE; N DESETYLAMIODARONE; PLACEBO; PROPAFENONE; SOTALOL; UNCLASSIFIED DRUG;

ACUTE DRUG ADMINISTRATION; AORTA STENOSIS; BIOACCUMULATION; CARDIOVERSION; CHRONIC DRUG ADMINISTRATION; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CORNEA TOXICITY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DIGOXIN BLOOD LEVEL; DOSE RESPONSE; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG MEGADOSE; DRUG SAFETY; DRUG STRUCTURE; DRUG WITHDRAWAL; ENZYME INHIBITION; EXPERIMENTAL DOG; EXPERIMENTAL PIG; EYE TOXICITY; GASTROINTESTINAL SYMPTOM; GLOMERULUS FILTRATION RATE; HEART ATRIUM FIBRILLATION; HEART ATRIUM FLUTTER; HEART ELECTROPHYSIOLOGY; HEART FAILURE; HEART LEFT VENTRICLE CONTRACTION; HEART MUSCLE POTENTIAL; HEART PAPILLARY MUSCLE; HEART PROARRHYTHMIA; HEART RATE; HEART REPOLARIZATION; HEART RHYTHM; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; KIDNEY CLEARANCE; LIOTHYRONINE BLOOD LEVEL; LIPOPHILICITY; LIVER TOXICITY; LOADING DRUG DOSE; LONG TERM CARE; LUNG TOXICITY; MORBIDITY; MORTALITY; N METHYLNICOTINAMIDE CLEARANCE; NONHUMAN; PREVENTIVE MEDICINE; PRIORITY JOURNAL; PURKINJE FIBER; QT DISPERSION; QT PROLONGATION; REVIEW; SIDE EFFECT; SINUS RHYTHM; SKIN TOXICITY; T WAVE AMPLITUDE; THROMBOEMBOLISM; THYROID DISEASE; THYROID GLAND TOXICITY; THYROXINE BLOOD LEVEL; TORSADE DES POINTES; TREATMENT FAILURE; UNSPECIFIED SIDE EFFECT;

EID: 72849115039     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10557-009-6189-0     Document Type: Review

References (28)

1. V Fuster LE Rydén DS Cannom American College of Cardiology; American Heart Association Task Force; European Society of Cardiology Committee for Practice Guidelines; European Heart Rhythm Association; Heart Rhythm Society. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 guidelines for the management of patients with atrial fibrillation) developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society, et al. 2006 Europace 8 651 745 10.1093/europace/eul097 16987906 (Pubitemid 44472247)
2. DG Wyse AL Waldo JP DiMarco, et al. 2002 Atrial fibrillation follow-up Investigation of rhythm management (AFFIRM) investigators. A comparison of rate control and rhythm control in patients with atrial fibrillation N Engl J Med 347 1825 1833 1:STN:280:DC%2BD38jgslKgug%3D%3D 12466506
3. JC Laughlin PR Kowey 2008 Dronedarone: a new treatment for atrial fibrillation J Cardiovasc Electrophysiol 19 1220 1226 10.1111/j.1540-8167.2008. 01251.x 18702618
4. JP Morrow CP Cannon JA Reiffel 2007 New antiarrhythmic drugs for establishing sinus rhythm in atrial fibrillation: what are our therapies likely to be by 2010 and beyond? Am Heart J. 154 824 829 10.1016/j.ahj.2007.06.041 1:CAS:528:DC%2BD2sXht1agsrzJ 17967585 (Pubitemid 350017712)
5. W Sun JS Sarma BN Sinqh 1999 Electrophysiological effects of dronedarone, a noniodinated benzofuran derivative, in the rabbit heart Circulation 100 2276 2281 1:CAS:528:DyaK1MXotVChsrg%3D 10578003
6. P Gautier E Guillemare A Marion JP Bertrand Y Tourneur D Nisato 2003 Electrophysiologic characterization of dronedarone in guinea pig ventricular cells J Cardiovasc Pharmacol 41 191 202 10.1097/00005344-200302000-00007 1:CAS:528:DC%2BD3sXlvFSjsA%3D%3D 12548079 (Pubitemid 36135243)
7. S Kathofer D Thomas CA Karle 2005 The novel antiarrhythmic drug dronedarone: comparison with amiodarone Cardiovasc Drug Rev 23 217 230 1:CAS:528:DC%2BD2MXht1CgsLzN 16252015
8. LM Hondeqhem DJ Snyders 1990 Class III antiarrhythmic agents have a lot of potential but a long way to go: reduced effectiveness and danger of reverse use dependence Circulation 81 686 690
9. A Varró J Takács M Németh, et al. 2001 Electrophysiological effects of dronedarone (SR 33589), a noniodinated amiodarone derivative in the canine heart: comparison with amiodarone Br J Pharmacol. 133 625 634 10.1038/sj.bjp.0704106 11429385
10. Y Tschuppert T Buclin LE Rothuizen, et al. 2007 Effect of dronedarone on renal function in healthy subjects Br J Clin Pharmacol. 64 785 791 1:CAS:528:DC%2BD1cXhtVKrtL0%3D 17662087
11. T Damy F Pousset H Caplain JS Hulot P Lechat 2004 Pharmacokinetic and pharmacodynamic interactions between metoprolol and dronedarone in extensive and poor CYP2D6 metabolizers healthy subjects Fundam Clin Pharmacol. 18 113 123 10.1046/j.1472-8206.2003.00216.x 1:CAS:528:DC%2BD2cXhsVSmtLo%3D 14748763 (Pubitemid 38200927)
12. JM Davy M Herold C Hoglund ERATO Study Investigators, et al. 2008 Dronedarone for the control of ventricular rate in permanent atrial fibrillation: the Efficacy and safety of dronedarone for the control of ventricular rate during atrial fibrillation (ERATO) study Am Heart J. 156 527 10.1016/j.ahj.2008.06.010 18760136 e1-9
13. O Finance A Manning P Chatelain 1995 Effects of a new amiodarone-like agent, SR 33589, in comparison to amiodarone, D, L-sotalol, and lignocaine, on ischemia-induced ventricular arrhythmias in anesthetized pigs J Cardiovasc Pharmacol 26 570 576 10.1097/00005344-199510000-00010 1:CAS:528: DyaK2MXotlequrY%3D 8569217
14. D Hodeige JP Heyndrickx P Chatelain A Manning 1995 SR 33589, a new amiodarone-like agent: Antiadrenoceptor activity in anaesthetized and conscious dogs Eur J Pharmacol 279 25 32 10.1016/0014-2999(95)00130-D 1:CAS:528: DyaK2MXmtVymtrY%3D 7556379
15. L Djandjighian J Planchenault O Finance G Pastor P Gautier D Nisato 2000 Hemodynamic and antiadrenergic effects of dronedarone and amiodarone in animals with a healed myocardial infarction J Cardiovasc Pharmacol 36 376 383 10.1097/00005344-200009000-00014 1:CAS:528:DC%2BD3cXmtVelt7c%3D 10975596
16. OC Yontar K Yalta MB Yilmaz OO Turgut 2008 Short QT syndrome: a very rare arrhythmogenic entity Acta Cardiol 63 553 555 10.2143/AC.63.5.2033220 19013996
17. K Ahmad P Dorian 2007 Drug-induced QT prolongation and proarrhythmia: an inevitable link Europace 9 IV16 22 10.1093/europace/eum167 17766320
18. JM van Opstal M Schoenmakers SC Verduyn, et al. 2001 Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT lengthening in an animal model with acquired long QT syndrome Circulation 104 2722 2727 10.1161/hc4701.099579 11723026
19. K Yalta A Yilmaz OO Turgut MB Yilmaz 2008 Reduced repolarization reserve: an important but not the unique predictor of drug induced fatal ventricular arrhythmia Int J Cardiol. 124 368 369 10.1016/j.ijcard.2007.04.093 (Pubitemid 351308149)
20. S Moro M Ferreiro D Celestino E Medei MV Elizari S Sicouri 2007 In vitro effects of acute amiodarone and dronedarone on epicardial, endocardial, and M cells of the canine ventricle J Cardiovasc Pharmacol Ther. 12 314 321 10.1177/1074248407306906 1:CAS:528:DC%2BD2sXhsVKjsr%2FN 18172226 (Pubitemid 350264696)
21. P Touboul J Brugada A Capucci HJGM Crijns N Edvardsson SH Hohnloser 2003 Dronedarone for prevention of atrial fibrillation: a dose-ranging study Eur Heart J 24 1481 1487 10.1016/S0195-668X(03)00321-X 1:CAS:528: DC%2BD3sXmt1Wqu7k%3D 12919771 (Pubitemid 37010577)
22. BN Singh SJ Connolly HJ Crijns EURIDIS ADONIS Investigators, et al. 2007 Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter N Engl J Med 357 987 999 10.1056/NEJMoa054686 1:CAS:528:DC%2BD2sXhtVensrfM 17804843 (Pubitemid 47367078)
23. L Køber C Torp-Pedersen JJ McMurray, et al. 2008 Dronedarone study group. Increased mortality after dronedarone therapy for severe heart failure. N Engl J Med. 358 2678 2687 10.1056/NEJMoa0800456 18565860 (Pubitemid 351860860)
24. I Savelieva J Camm 2008 Anti-arrhythmic drug therapy for atrial fibrillation: current arrhythmic drugs, investigational agents, and innovative approaches Europace 10 647 665 10.1093/europace/eun130 18515286 (Pubitemid 351775283)
25. SH Hohnloser HJ Crijns M van Eickels ATHENA Investigators, et al. 2009 Effect of dronedarone on cardiovascular events in atrial fibrillation N Engl J Med 360 668 678 10.1056/NEJMoa0803778 1:CAS:528:DC%2BD1MXhvVyisbg%3D 19213680
26. Sanofi-aventis (Paris Bourse: EURONEXT: SAN; and NewYork: NYSE: SNY) Press Release. DIONYSOS Study Results Showed the Respective Profiles of Dronedarone and Amiodarone. Paris, France - December 23, 2008.
27. A Beri SR Punnam 2008 Anticoagulation in patients with acute ischemic stroke and atrial fibrillation-a balance of risks and benefits Cardiovasc Drugs Ther. 22 419 425 10.1007/s10557-008-6122-y 1:CAS:528:DC%2BD1cXhtVOntrzF 18642133
28. AR Riera AH Uchida C Ferreira, et al. 2008 Relationship among amiodarone, new class III antiarrhythmics, miscellaneous agents and acquired long QT syndrome Cardiol J. 15 209 219 18651412