Quantification of T-cell proliferation for individualizing immunosuppressive therapy for transplantation patients

Clinical Pharmacology and Therapeutics

Volumn 87, Issue 1, 2010, Pages 23-26

  Ohdan, H ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT;

ASSAY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DRUG MONITORING; DRUG SENSITIVITY; GRAFT REJECTION; HUMAN; IMMUNE RESPONSE; IMMUNE STATUS; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MIXED LYMPHOCYTE REACTION; MONITORING; ORGAN TRANSPLANTATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PHARMACODYNAMICS; PRIORITY JOURNAL; SHORT SURVEY; T LYMPHOCYTE;

CELL PROLIFERATION; DRUG MONITORING; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INDIVIDUALIZED MEDICINE; KIDNEY TRANSPLANTATION; LYMPHOCYTE COUNT; T-LYMPHOCYTES;

EID: 72849110128     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2009.171     Document Type: Short Survey

References (10)

1. Ashton-Chess, J., Giral, M., Soulillou, J.P. & Brouard, S. Can immune monitoring help to minimize immunosuppression in kidney transplantation? Transpl. Int. 22, 110-119 (2009).
2. Wavamunno, M.D. & Chapman, J.R. Individualization of immunosuppression: concepts and rationale. Curr. Opin. Organ Transplant. 13, 604-608 (2008).
3. Kurata, Y. et al. Pretransplant pharmacodynamic analysis of immunosuppressive agents using CFSE-based T-cell proliferation assay. Clin. Pharmacol. Ther. 86, 285-289 (2009).
4. Hirano, T. Cellular pharmacodynamics of immunosuppressive drugs for individualized medicine. Int. Immunopharmacol. 7, 3-22 (2007).
5. Wells, A.D., Gudmundsdottir, H. & Turka, L.A. Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. J. Clin. Invest. 100, 3173-3183 (1997).
6. Paramore, C.G., Turner, D.A. & Madison, R.D. Fluorescent labeling of dissociated fetal cells for tissue culture. J. Neurosci. Methods 44, 7-17 (1992).
7. Tanaka, Y., Ohdan, H., Onoe, T. & Asahara, T. Multiparameter flow cytometric approach for simultaneous evaluation of proliferation and cytokine-secreting activity in T cells responding to allo-stimulation. Immunol. Invest. 33, 309-324 (2004).
8. Orosz, C.G., Zinn, N.E., Sirinek, L.P. & Ferguson, R.M. Size of the donor-reactive CTL pool determined by limiting dilution analysis in sponge matrix allografts. Transplantation 41, 400-404 (1986).
9. Tanaka, Y. et al. Low incidence of acute rejection after living-donor liver transplantation: immunologic analyses by mixed lymphocyte reaction using a carboxyfluorescein diacetate succinimidyl ester labeling technique. Transplantation 79, 1262-1267 (2005).
10. Tahara, H. et al. Successful hepatitis B vaccination in liver transplant recipients with donor-specific hyporesponsiveness. Transpl. Int. 22, 805-813 (2009).