Effects of Qushi Huayu Decoction in prevention and treatment of fatty liver in rats based on adiponection-free fatty acid pathway

Journal of Chinese Integrative Medicine

Volumn 7, Issue 6, 2009, Pages 546-551

  Li, Hong Shan ^a,b   Feng, Qin ^a   Xu, Li Li ^a   Chen, Shao Dong ^a   Li, Xue Mei ^a   Hu, Yi Yang ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Ningbo Infectious Disease Hospital   (China)

Author keywords

Adiponectin; AMP activated protein kinase; Fatty liver; Free fatty acid; Qushi Huayu Decoction; Rats

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADIPONECTIN; ADIPONECTIN RECEPTOR 2; CARBON TETRACHLORIDE; CARNITINE PALMITOYLTRANSFERASE I; CHINESE DRUG; EOSIN; FATTY ACID; FATTY ACID SYNTHASE; HEMATOXYLIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MALONYL COENZYME A; QUSHI HUAYU; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHINESE MEDICINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE MODEL; DRUG DOSE COMPARISON; DRUG MEGADOSE; HISTOCHEMISTRY; HISTOPATHOLOGY; LIPID DIET; LIVER PARENCHYMA; LOW DRUG DOSE; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PROTEIN RESTRICTION; RAT;

ADIPONECTIN; ANIMALS; CARBON TETRACHLORIDE; CARBON TETRACHLORIDE POISONING; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; FATTY ACIDS, NONESTERIFIED; FATTY LIVER; MALE; PHYTOTHERAPY; RANDOM ALLOCATION; RATS; RATS, WISTAR; RECEPTORS, ADIPONECTIN;

EID: 72849106154     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20090610     Document Type: Article

References (12)

1. Zhang H, Feng Q, Hu YY, Liu CH, Liu P. Prevention and treatment of "Qushi Huayu Decoction" on fatty liver of rats induced by carbon tetrachloride along with high-fat and low-protein diet. Shanghai Zhong Yi Yao Za Zhi. 2006; 40(3): 52-55. Chinese with abstract in English.
2. Feng Q, Zhang H, Hu YY, Lu X, Liu CH, Liu P. Effect of Qushi Huayu decoction on prevention and treatment of fatty liver induced by high-fat diet in rats. Zhong Xi Yi Jie He Gan Bing Za Zhi. 2006; 16(1): 26-29. Chinese with abstract in English.
3. Zhang H, Feng Q, Li HS, Chen SD, Wang XN, Peng JH, Zhang N, Hu YY. Effects of Qushi Huayu Decoction on cathepsin B and tumor necrosis factor-α expression in rats with non-alcoholic steatohepatitis. J Chin Integr Med. 2008; 6(9): 928-933. Chinese with abstract in English.
4. Zhang H, Hu YY, Feng Q, Chen SD, Xu LL, Cheng Y, Zhang N. Inhibitory effects of Qushi Huayu Decoration on fatty deposition and tumor necrosis factor α secretion in HepG2 cells induced by free fatty acid. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007; 27(12): 1105-1109. Chinese with abstract in English.
5. Fatty Liver and Alcoholic Liver Disease Study Group of Chinese Liver Disease Association. Guidelines for diagnosis and treatment of nonalcoholic fatty liver diseases. Zhonghua Gan Zang Bing Za Zhi. 2006; 14(3): 161-163. Chinese.
6. Zeng MD. Glucotoxicity, lipotoxicity and the nonalcoholic fatty liver disease. Zhonghua Gan Zang Bing Za Zhi. 2005; 13(2): 281-82. Chinese.
7. Xu ZJ, Fan JG, Wang GL. The role of free fatty acid in steatohepatitis. Zhonghua Gan Zang Bing Za Zhi. 2000; 8(2): 127-128. Chinese.
8. Ahima RS. Adipose tissue as an endocrine organ. Obesity (Silver Spring). 2006; 14(5): 242-249.
9. Andreelli F, Foretz M, Knauf C, Cani PD, Perrin C, Iglesias MA, Pillot B, Bado A, Tronche F, Mithieux G, Vaulont S, Burcelin R, Viollet B. Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin. Endocrinology. 2006; 147(5): 2432-2441.
10. Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, Bihain BE, Lodish HF. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci U S A. 2001; 98(4): 2005-2010. (Pubitemid 32165613)
11. You M, Matsumoto M, Pacold CM, Cho WK, Crabb DW. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology. 2004; 127(6): 1798-1808. (Pubitemid 39575858)
12. You M, Considine RV, Leone TC, Kelly DP, Crabb DW. Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology. 2005; 42(3): 568-577. (Pubitemid 41233649)