Heating increases protoporphyrin IX production in normal skin after delivery of 5-aminolevulinic acid by iontophoresis

Photodermatology Photoimmunology and Photomedicine

Volumn 25, Issue 6, 2009, Pages 333-334

  Ishida, Natsuko ^a   Watanabe, Daisuke ^a   Mizutanil, Kimihiko ^a,b   Akimoto, Makio ^b   Nakano, Aki ^a   Akita, Yoichi ^a   Tamada, Yasuhiko ^a   Matsumoto, Yoshinari ^a  

^a AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KANTO GAKUIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOLEVULINIC ACID; PROTOPORPHYRIN;

ADULT; CLINICAL ARTICLE; FLUORESCENCE; HEATING; HUMAN; IONTOPHORESIS; LETTER; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PULSE WAVE;

ADULT; AMINOLEVULINIC ACID; HOT TEMPERATURE; HUMANS; IONTOPHORESIS; MALE; MIDDLE AGED; PHOTOSENSITIZING AGENTS; PROTOPORPHYRINS; SKIN; SKIN NEOPLASMS;

EID: 72749120825     PISSN: 09054383     EISSN: 16000781     Source Type: Journal    
DOI: 10.1111/j.1600-0781.2009.00461.x     Document Type: Letter

References (5)

1. Mizutani K, Watanabe D, Akita Y, et al. Photodynamic therapy using direct-current pulsed iontophoresis for 5-aminolevulinic acid application. Photodermatol Photoimmunol Photomed, in press.
2. Gerscher S, Connelly JP, Beijersbergen Van Henegouwen GM, MacRobert AJ, Watt P, Rhodes L.E. A quantitative assessment of protoporphyrin IX metabolism and phototoxicity in human skin following dose-controlled delivery of the prodrugs 5-aminolaevulinic acid and 5-aminolaevulinic acid-n-pentylester. Br J Dermatol 2001; 144: 983-990.
3. van den Akker JT, Boot K, Vernon DI, et al. Effect of elevating the skin temperature during topical ALA application on in vitro ALA penetration through mouse skin and in vivo PpIX production in human skin. Photochem Photobiol Sci. 2004; 3: 263-267.
4. Juzenas P, Sorensen R, Iani V, Moan J. Uptake of topically applied 5-aminolevulinic acid and production of Protoporphyrin IX in normal mouse skin: dependence on skin temperature. Photochem Photobiol 1999; 69: 478-481.
5. Shioi Y, Nagamine M, Kuroki M, Sasa T. Purification by affinity chromatography and properties of uroporphyrinogen IX synthetase from Chlorella. Biochim Biophys Acta 1980; 616: 300-309.