Parabutoporin, a cationic amphipathic peptide from scorpion venom: Much more than an antibiotic

Toxicon

Volumn 55, Issue 2-3, 2010, Pages 180-185

  Remijsen, Q ^a   Verdonck, F ^a   Willems, J ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Antimicrobial; NADPH oxidase; Neutrophil; PKC; Scorpion; Venom

Indexed keywords

PARABUTOPORIN; POLYPEPTIDE ANTIBIOTIC AGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SCORPION VENOM; SUPEROXIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; CELL FUNCTION; CONCENTRATION RESPONSE; DEGRANULATION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; IMMUNOREGULATION; INNATE IMMUNITY; MINIMUM INHIBITORY CONCENTRATION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PARABUTHUS SCHLECHTERI; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; REVIEW; SCORPION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; APOPTOSIS; CELL DEGRANULATION; CELL MOVEMENT; ENZYME INHIBITORS; HUMANS; MOLECULAR SEQUENCE DATA; NADPH OXIDASE; NEUTROPHILS; SCORPION VENOMS; SCORPIONS; SUPEROXIDES;

PARABUTHUS SCHLECHTERI; SCORPIONES;

EID: 72749116868     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.10.027     Document Type: Review

References (57)

1. Babior B.M. NADPH oxidase: an update. Blood 93 (1999) 1464-1476
2. Barlow P.G., Li Y., Wilkinson T.S., Bowdish D.M., Lau Y.E., Cosseau C., Haslett C., Simpson A.J., Hancock R.E., and Davidson D.J. The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. J Leukoc Biol 80 (2006) 509-520
3. van den Berg J.M., van Koppen E., Ahlin A., Belohradsky B.H., Bernatowska E., Corbeel L., Espanol T., Fischer A., Kurenko-Dept M.R., Petropoulou T., Roesler J., Seger R., Stasia M.J., Valerius N.H., Weening R.S., Wolach B., Roos D., and Kuijpers T.W. Chronic granulomatous disease: the European experience. PLoS ONE 4 (2009) e5234
4. Bowdish D.M., Davidson D.J., Lau Y.E., Lee K., Scott M.G., and Hancock R.E. Impact of LL-37 on anti-infective immunity. J Leukoc Biol 77 (2005) 451-459
5. Chippaux J.P., and Goyffon M. Epidemiology of scorpionism: a global appraisal. Acta Trop 107 (2008) 71-79
6. Clark R.A., and Klebanoff S.J. Chemotactic factor inactivation by the myeloperoxidase-hydrogen peroxide-halide system. J Clin Invest 64 (1979) 913-920
7. Cociancich S., Goyffon M., Bontems F., Bulet P., Bouet F., Menez A., and Hoffmann J. Purification and characterization of a scorpion defensin, a 4 kDa antibacterial peptide presenting structural similarities with insect defensins and scorpion toxins. Biochem Biophys Res Commun 194 (1993) 17-22
8. Conde R., Zamudio F.Z., Rodriguez M.H., and Possani L.D. Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom. FEBS Lett 471 (2000) 165-168
9. Corzo G., Escoubas P., Villegas E., Barnham K.J., He W., Norton R.S., and Nakajima T. Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator. Biochem J 359 (2001) 35-45
10. Dai L., Yasuda A., Naoki H., Corzo G., Andriantsiferana M., and Nakajima T. IsCT, a novel cytotoxic linear peptide from scorpion Opisthacanthus madagascariensis. Biochem Biophys Res Commun 286 (2001) 820-825
11. De Y., Chen Q., Schmidt A.P., Anderson G.M., Wang J.M., Wooters J., Oppenheim J.J., and Chertov O. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med 192 (2000) 1069-1074
12. Dyason K., Brandt W., Prendini L., Verdonck F., Tytgat J., du P.J., Muller G., and van der Walt J. Determination of species-specific components in the venom of Parabuthus scorpions from southern Africa using matrix-assisted laser desorption time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 16 (2002) 768-773
13. Elgar D., Verdonck F., Grobler A., Fourie C., and du P.J. Ion selectivity of scorpion toxin-induced pores in cardiac myocytes. Peptides 27 (2006) 55-61
14. Fontayne A., Dang P.M., Gougerot-Pocidalo M.A., and El Benna J. Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation. Biochemistry 41 (2002) 7743-7750
15. Gallo R.L., Ono M., Povsic T., Page C., Eriksson E., Klagsbrun M., and Bernfield M. Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. Proc Natl Acad Sci USA 91 (1994) 11035-11039
16. Giacometti A., Cirioni O., Ghiselli R., Mocchegiani F., Del Prete M.S., Viticchi C., Kamysz W., LEmpicka E., Saba V., and Scalise G. Potential therapeutic role of cationic peptides in three experimental models of septic shock. Antimicrob Agents Chemother 46 (2002) 2132-2136
17. Hancock R.E. Cationic peptides: effectors in innate immunity and novel antimicrobials. Lancet Infect Dis 1 (2001) 156-164
18. Hancock R.E., and Diamond G. The role of cationic antimicrobial peptides in innate host defences. Trends Microbiol 8 (2000) 402-410
19. Inceoglu B., Lango J., Jing J., Chen L., Doymaz F., Pessah I.N., and Hammock B.D. One scorpion, two venoms: prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action. Proc Natl Acad Sci USA 100 (2003) 922-927
20. Jenssen H., Hamill P., and Hancock R.E. Peptide antimicrobial agents. Clin Microbiol Rev 19 (2006) 491-511
21. Kleinberg M.E., Malech H.L., Mital D.A., and Leto T.L. p21rac does not participate in the early interaction between p47-phox and cytochrome b558 that leads to phagocyte NADPH oxidase activation in vitro. Biochemistry 33 (1994) 2490-2495
22. Koczulla R., von Degenfeld G., Kupatt C., Krotz F., Zahler S., Gloe T., Issbrucker K., Unterberger P., Zaiou M., Lebherz C., Karl A., Raake P., Pfosser A., Boekstegers P., Welsch U., Hiemstra P.S., Vogelmeier C., Gallo R.L., Clauss M., and Bals R. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest 111 (2003) 1665-1672
23. Kuhn-Nentwig L. Antimicrobial and cytolytic peptides of venomous arthropods. Cell Mol Life Sci 60 (2003) 2651-2668
24. Kwong C.H., Malech H.L., Rotrosen D., and Leto T.L. Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins. Biochemistry 32 (1993) 5711-5717
25. Lee K., Shin S.Y., Kim K., Lim S.S., Hahm K.S., and Kim Y. Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs. Biochem Biophys Res Commun 323 (2004) 712-719
26. Li S., Yamauchi A., Marchal C.C., Molitoris J.K., Quilliam L.A., and Dinauer M.C. Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions. J Immunol 169 (2002) 5043-5051
27. Luo H.R., and Loison F. Constitutive neutrophil apoptosis: mechanisms and regulation. Am J Hematol 83 (2008) 288-295
28. Maianski N.A., Maianski A.N., Kuijpers T.W., and Roos D. Apoptosis of neutrophils. Acta Haematol 111 (2004) 56-66
29. Moerman L., Bosteels S., Noppe W., Willems J., Clynen E., Schoofs L., Thevissen K., Tytgat J., Van Eldere J., van der Walt J., and Verdonck F. Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa. Eur J Biochem 269 (2002) 4799-4810
30. Moerman L., Verdonck F., Willems J., Tytgat J., and Bosteels S. Antimicrobial peptides from scorpion venom induce Ca(2+) signaling in HL-60 cells. Biochem Biophys Res Commun 311 (2003) 90-97
31. Mookherjee N., and Hancock R.E. Cationic host defence peptides: innate immune regulatory peptides as a novel approach for treating infections. Cell Mol Life Sci 64 (2007) 922-933
32. Norgauer J., Eberle M., Lemke H.D., and Aktories K. Activation of human neutrophils by mastoparan. Reorganization of the cytoskeleton, formation of phosphatidylinositol 3,4,5-trisphosphate, secretion up-regulation of complement receptor type 3 and superoxide anion production are stimulated by mastoparan. Biochem J 282 Pt 2 (1992) 393-397
33. du Plessis L.H., Elgar D., and du Plessis J.L. Southern African scorpion toxins: an overview. Toxicon 51 (2008) 1-9
34. Reeves E.P., Dekker L.V., Forbes L.V., Wientjes F.B., Grogan A., Pappin D.J., and Segal A.W. Direct interaction between p47phox and protein kinase C: evidence for targeting of protein kinase C by p47phox in neutrophils. Biochem J 344 3 (1999) 859-866
35. Remijsen Q., Vanden Berghe T., Parthoens E., Asselbergh B., Vandenabeele P., and Willems J. Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt. J Leukoc Biol 85 (2009) 497-507
36. Remijsen Q., Fontayne A., Verdonck F., Clynen E., Schoofs L., and Willems J. The antimicrobial peptide parabutoporin competes with p47(phox) as a PKC-substrate and inhibits NADPH oxidase in human neutrophils. FEBS Lett 580 (2006) 6206-6210
37. Rodriguez de la Vega R.C., and Possani L.D. Current views on scorpion toxins specific for K+-channels. Toxicon 43 (2004) 865-875
38. Rodriguez de la Vega R.C., and Possani L.D. Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure-function relationships and evolution. Toxicon 46 (2005) 831-844
39. Romani L., Fallarino F., De Luca A., Montagnoli C., D'Angelo C., Zelante T., Vacca C., Bistoni F., Fioretti M.C., Grohmann U., Segal B.H., and Puccetti P. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature 451 (2008) 211-215
40. Scott M.G., Davidson D.J., Gold M.R., Bowdish D., and Hancock R.E. The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol 169 (2002) 3883-3891
41. Segal A.W. How neutrophils kill microbes. Annu Rev Immunol 23 (2005) 197-223
42. Tisch D., Sharoni Y., Danilenko M., and Aviram I. The assembly of neutrophil NADPH oxidase: effects of mastoparan and its synthetic analogues. Biochem J 310 Pt 2 (1995) 715-719
43. Tisch-Idelson D., Fridkin M., Wientjes F., and Aviram I. Structure-function relationship in the interaction of mastoparan analogs with neutrophil NADPH oxidase. Biochem Pharmacol 61 (2001) 1063-1071
44. Torres-Larios A., Gurrola G.B., Zamudio F.Z., and Possani L.D. Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus. Eur J Biochem 267 (2000) 5023-5031
45. Tytgat J., Chandy K.G., Garcia M.L., Gutman G.A., Martin-Eauclaire M.F., van der Walt J., and Possani L.D. A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies. Trends Pharmacol Sci 20 (1999) 444-447
46. Verdonck F., Bosteels S., Desmet J., Moerman L., Noppe W., Tytgat J., and van der Walt J. A novel class of pore-forming peptides from the venom of Parabuthus schlechteri (Purcell). Cimbebasia (2000) 247-260
47. Willems J., Moerman L., Bosteels S., Bruyneel E., Ryniers F., and Verdonck F. Parabutoporin - an antibiotic peptide from scorpion venom - can both induce activation and inhibition of granulocyte cell functions. Peptides 25 (2004) 1079-1084
48. Willems J., Noppe W., Moerman L., van der Walt J., and Verdonck F. Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes. Toxicon 40 (2002) 1679-1683
49. Winkelstein J.A., Marino M.C., Johnston Jr. R.B., Boyle J., Curnutte J., Gallin J.I., Malech H.L., Holland S.M., Ochs H., Quie P., Buckley R.H., Foster C.B., Chanock S.J., and Dickler H. Chronic granulomatous disease. Report on a national registry of 368 patients. Medicine (Baltimore) 79 (2000) 155-169
50. Yang D., Biragyn A., Kwak L.W., and Oppenheim J.J. Mammalian defensins in immunity: more than just microbicidal. Trends Immunol 23 (2002) 291-296
51. Zaiou M. Multifunctional antimicrobial peptides: therapeutic targets in several human diseases. J Mol Med 85 (2007) 317-329
52. Zeng X.C., Corzo G., and Hahin R. Scorpion venom peptides without disulfide bridges. IUBMB Life 57 (2005) 13-21
53. Zeng X.C., Li W.X., Peng F., and Zhu Z.H. Cloning and characterization of a novel cDNA sequence encoding the precursor of a novel venom peptide (BmKbpp) related to a bradykinin-potentiating peptide from Chinese scorpion Buthus martensii Karsch. IUBMB Life 49 (2000) 207-210
54. Zhang L., Rozek A., and Hancock R.E. Interaction of cationic antimicrobial peptides with model membranes. J Biol Chem 276 (2001) 35714-35722
55. Zheng Y., Niyonsaba F., Ushio H., Nagaoka I., Ikeda S., Okumura K., and Ogawa H. Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils. Br J Dermatol 157 (2007) 1124-1131
56. Zhijian C., Feng L., Yingliang W., Xin M., and Wenxin L. Genetic mechanisms of scorpion venom peptide diversification. Toxicon 47 (2006) 348-355
57. Zhu S., Li W., Jiang D., and Zeng X. Evidence for the existence of insect defensin-like peptide in scorpion venom. IUBMB Life 50 (2000) 57-61