Meet the corneal myofibroblast: The role of myofibroblast transformation in corneal wound healing and pathology

Veterinary Ophthalmology

Volumn 12, Issue SUPPL. 1, 2009, Pages 25-27

  Myrna, Kathern E ^a   Pot, Simon A ^a   Murphy, Christopher J ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cornea; Corneal wound healing; Myofibroblast; Stroma

Indexed keywords

ANIMAL; CLASSIFICATION; CORNEA; CYTOLOGY; FIBROBLAST; INJURY; PHYSIOLOGY; REVIEW; WOUND HEALING;

ANIMALS; CORNEA; FIBROBLASTS; WOUND HEALING;

EID: 72749116727     PISSN: 14635216     EISSN: 14635224     Source Type: Journal    
DOI: 10.1111/j.1463-5224.2009.00742.x     Document Type: Review

References (39)

1. Krachmer JH, Mannis MJ, Holland EJ. Cornea, 2nd edn. Elsevier Mosby, Philadelphia, 2005.
2. Walshe R, Esser P, Wiedemann P et al. Proliferative retinal diseases: myofibroblasts cause chronic vitreoretinal traction. British Journal of Ophthalmology 1992 76 (9) 550 552.
3. Gamulescu MA, Chen Y, He S et al. Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Experimental Eye Research 2006 83 : 212 222.
4. Guidry C, King JL, Mason JO 3rd. Fibrocontractive muller cell phenotypes in proliferative diabetic retinopathy. Investigative Ophthalmology and Visual Science 2009 50 : 1929 1939.
5. Colitz CM, Malarkey D, Dykstra MJ, McGahan MC, Davidson MG. Histologic and immunohistochemical characterization of lens capsular plaques in dogs with cataracts. American Journal of Veterinary Research 2000 61 : 139 143.
6. Gerardi JG, Colitz CM, Dubielzig RR, Davidson MG. Immunohistochemical analysis of lens epithelial-derived membranes following cataract extraction in the dog. Veterinary Ophthalmology 1999 2 : 163 168.
7. Saika S. TGF beta pathobiology in the eye. Laboratory Investigation 2006 86 : 106 115.
8. You L, Kruse FE, Pohl J, Volcker HE. Bone morphogenetic proteins and growth and differentiation factors in the human cornea. Investigative Ophthalmology and Visual Science 1999 40 : 296 311.
9. Fini ME. Keratocyte and fibroblast phenotypes in the repairing cornea. Progress in Retinal and Eye Research 1999 18 : 529 551.
10. Saika S, Yamanaka O, Sumioka T et al. Fibrotic disorders in the eye: targets of gene therapy. Progress in Retinal and Eye Research 2008 27 : 177 196.
11. Hinz B, Mastrangelo D, Iselin CE, Chaponnier C, Gabbiani G. Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation. American Journal of Pathology 2001 159 : 1009 1020.
12. Jester JV, Ho-Chang J. Modulation of cultured corneal keratocyte phenotype by growth factors/cytokines control in vitro contractility and extracellular matrix contraction. Experimental Eye Research 2003 77 : 581 592.
13. Jester JV, Petroll WM, Barry PA, Cavanagh HD. Expression of alpha-smooth muscle (alpha-SM) actin during corneal stromal wound healing. Investigative Ophthalmology and Visual Science 1995 36 : 809 819.
14. Hinz B. Formation and function of the myofibroblast during tissue repair. Journal of Investigative Dermatology 2007 127 : 526 537.
15. Funderburgh JL, Funderburgh ML, Mann MM, Corpuz L, Roth MR. Proteoglycan expression during transforming growth factor beta-induced keratocyte- myofibroblast transdifferentiation. The Journal of Biological Chemistry 2001 276 : 44173 44178.
16. Maltseva O, Folger P, Zekaria D, Petridou S, Masur SK. Fibroblast growth factor reversal of the corneal myofibroblast phenotype. Investigative Ophthalmology and Visual Science 2001 42 : 2490 2495.
17. Musselmann K, Alexandrou B, Kane B, Hassell JR. Maintenance of the keratocyte phenotype during cell proliferation stimulated by insulin. Journal of Biological Chemistry 2005 280 : 32634 32639.
18. He J, Bazan HE. Epidermal growth factor synergism with TGF-beta1 via PI-3 kinase activity in corneal keratocyte differentiation. Investigative Ophthalmology and Visual Science 2008 49 : 2936 2945.
19. Fuchshofer R, Yu AL, Teng HH, Strauss R, Kampik A, Welge-Lussen U. Hypoxia/reoxygenation induces CTGF and PAI-1 in cultured human retinal pigment epithelium cells. Experimental Eye Research 2008 88 : 889 899.
20. Myrna KE, Russell P, Liliensiek S et al. Substratum topography modulates alpha SMA expression in corneal stromal cells. Invest Ophthalmol Vis Sci 2009 50 : E-Abstract 3068.
21. Pot SA, Liliensiek SJ, Bentley E et al. Substratum topography modulates cell shape, orientation, migration and alpha SMA mRNA expression of rabbit keratocytes and myofibroblasts. Invest Ophthalmol Vis Sci 2007 48 : E-Abstract 1962.
22. Wilson SE. Analysis of the keratocyte apoptosis, keratocyte proliferation, and myofibroblast transformation responses after photorefractive keratectomy and laser in situ keratomileusis. Transactions of the American Ophthalmological Society 2002 100 : 411 433.
23. Moller-Pedersen T, Cavanagh HD, Petroll WM, Jester JV. Corneal haze development after PRK is regulated by volume of stromal tissue removal. Cornea 1998 17 : 627 639.
24. Moller-Pedersen T, Cavanagh HD, Petroll WM, Jester JV. Neutralizing antibody to TGF beta modulates stromal fibrosis but not regression of photoablative effect following PRK. Current Eye Research 1998 17 : 736 747.
25. Moller-Pedersen T, Li HF, Petroll WM, Cavanagh HD, Jester JV. Confocal microscopic characterization of wound repair after photorefractive keratectomy. Investigative Ophthalmology and Visual Science 1998 39 : 487 501.
26. Zieske JD, Guimaraes SR, Hutcheon AE. Kinetics of keratocyte proliferation in response to epithelial debridement. Experimental Eye Research 2001 72 : 33 39.
27. Jester JV, Petroll WM, Barry PA, Cavanagh HD. Temporal, 3-dimensional, cellular anatomy of corneal wound tissue. Journal of Anatomy 1995 186 (Pt 2) 301 311.
28. Masur SK, Cheung JK, Antohi S. Identification of integrins in cultured corneal fibroblasts and in isolated keratocytes. Investigative Ophthalmology and Visual Science 1993 34 : 2690 2698.
29. Petroll WM, Cavanagh HD, Jester JV. Three-dimensional imaging of corneal cells using in vivo confocal microscopy. Journal of Microscopy 1993 170 (Pt 3) 213 219.
30. Ebihara N, Yamagami S, Chen L et al. Expression and function of toll-like receptor-3 and -9 in human corneal myofibroblasts. Investigative Ophthalmology and Visual Science 2007 48 : 3069 3076.
31. Priglinger SG, May CA, Alge CS et al. Absence of scar formation in human donor cornea with prior laser in situ keratomileusis. Journal of Cataract and Refractive Surgery 2005 31 : 1403 1408.
32. Jester JV, Steel D, Salz J et al. Radial keratotomy in non-human primate eyes. American Journal of Ophthalmology 1981 92 : 153 171. (Pubitemid 11014297)
33. Jester JV, Petroll WM, Feng W, Essepian J, Cavanagh HD. Radial keratotomy. 1. The wound healing process and measurement of incisional gape in two animal models using in vivo confocal microscopy. Investigative Ophthalmology and Visual Science 1992 33 : 3255 3270.
34. Jester JV, Petroll WM, Garana RM, Lemp MA, Cavanagh HD. Comparison of in vivo and ex vivo cellular structure in rabbit eyes detected by tandem scanning microscopy. Journal of Microscopy 1992 165 (Pt 1 )169 181.
35. Wilson SE, Mohan RR, Mohan RR, Ambrosio R Jr., Hong J, Lee J. The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Progress in Retinal and Eye Research 2001 20 : 625 637.
36. Jester JV, Budge A, Fisher S, Huang J. Corneal keratocytes: phenotypic and species differences in abundant protein expression and in vitro light-scattering. Investigative Ophthalmology and Visual Science 2005 46 : 2369 2378.
37. Nakano Y, Oyamada M, Dai P, Nakagami T, Kinoshita S, Takamatsu T. Connexin43 knockdown accelerates wound healing but inhibits mesenchymal transition after corneal endothelial injury in vivo. Investigative Ophthalmology and Visual Science 2008 49 : 93 104.
38. Michels RG, Kenyon KR, Maumence AE. Retrocorneal fibrous membrane. Investigative Ophthalmology 1972 11 : 822 831.
39. Petroll WM, Barry-Lane PA, Cavanagh HD, Jester JV. ZO-1 reorganization and myofibroblast transformation of corneal endothelial cells after freeze injury in the cat. Experimental Eye Research 1997 64 : 257 267.