Characterization of ricin toxin family members from Ricinus communis

Toxicon

Volumn 55, Issue 2-3, 2010, Pages 658-661

  Leshin, Jonathan ^a   Danielsen, Mark ^b   Credle, Joel J ^b   Weeks, Andrea ^c   O'Connell, Kevin P ^d   Dretchen, Kenneth ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GEORGE MASON UNIVERSITY   (United States)

^d EDGEWOOD CHEMICAL BIOLOGICAL CENTER   (United States)

Author keywords

Biodefense; Preproricin; Ribosome inactivating protein; Ricin; Ricin toxin A chain; Ricinus communis

Indexed keywords

ADENINE; CHLORAMPHENICOL ACETYLTRANSFERASE; LUCIFERASE; RICIN; RNA 28S;

ARTICLE; CONTROLLED STUDY; HYDROLYSIS; IN VITRO STUDY; INHIBITION KINETICS; MOLECULAR CLONING; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; RICINUS COMMUNIS; RNA TRANSCRIPTION; RNA TRANSLATION; TOXIN ANALYSIS;

ANIMALS; GENOME, PLANT; PLASMIDS; PROTEIN BIOSYNTHESIS; RABBITS; RETICULOCYTES; RICIN; RICINUS; RNA, RIBOSOMAL, 28S; TRANSCRIPTION, GENETIC;

RICINUS COMMUNIS;

EID: 72749084794     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.09.002     Document Type: Article

References (10)

1. Endo Y., Gluck A., and Wool I.G. Ribosomal RNA identity elements for ricin A-chain recognition and catalysis. Journal of Molecular Biology 221 1 (1991) 193-207
2. Endo Y., Mitsui K., Motizuki M., and Tsurugi K. The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28S ribosomal RNA caused by the toxins. The Journal of Biological Chemistry 262 12 (1987) 5908-5912
3. Funatsu G., Islam M.R., Minami Y., Sung-Sil K., and Kimura M. Conserved amino acid residues in ribosome-inactivating proteins from plants. Biochimie 73 7-8 (1991) 1157-1161
4. Halling K.C., Halling A.C., Murray E.E., Ladin B.F., Houston L.L., and Weaver R.F. Genomic cloning and characterization of a ricin gene from Ricinus communis. Nucleic Acids Research 13 22 (1985) 8019-8033
5. Marsden C.J., Fulop V., Day P.J., and Lord J.M. The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain. European Journal of Biochemistry/FEBS 271 1 (2004) 153-162
6. May M.J., Hartley M.R., Roberts L.M., Krieg P.A., Osborn R.W., and Lord J.M. Ribosome inactivation by ricin A chain: a sensitive method to assess the activity of wild-type and mutant polypeptides. The EMBO Journal 8 1 (1989) 301-308
7. Olsnes S. The history of ricin, abrin and related toxins. Toxicon 44 4 (2004) 361-370
8. Stirpe F., Bailey S., Miller S.P., and Bodley J.W. Modification of ribosomal RNA by ribosome-inactivating proteins from plants. Nucleic Acids Research 16 4 (1988) 1349-1357
9. Tregear J.W., and Roberts L.M. The lectin gene family of Ricinus communis: cloning of a functional ricin gene and three lectin pseudogenes. Plant Molecular Biology 18 3 (1992) 515-525
10. Voss C., Eyol E., Frank M., von der Lieth C.W., and Berger M.R. Identification and characterization of riproximin, a new type II ribosome-inactivating protein with antineoplastic activity from Ximenia americana. The FASEB Journal 20 8 (2006) 1194-1196