Proteins involved in iron metabolism in beef cattle are affected by copper deficiency in combination with high dietary manganese, but not by copper deficiency alone

Journal of Animal Science

Volumn 88, Issue 1, 2010, Pages 275-283

  Hansen, S L ^a   Trakooljul, N ^a   Liu, H C S ^a   Hicks, J A ^a   Ashwell, M S ^a   Spears, J W ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Cattle; Copper; Iron; Metal transporter

Indexed keywords

CATION TRANSPORT PROTEIN; COPPER; IRON; MANGANESE;

ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; ARTICLE; BLOOD; CATTLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET; DOSE RESPONSE; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; RANDOMIZED CONTROLLED TRIAL;

ANIMAL FEED; ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; CATION TRANSPORT PROTEINS; CATTLE; COPPER; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION; IRON; MALE; MANGANESE;

BOS;

EID: 72649104760     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2009-1846     Document Type: Article

References (26)

1. Arredondo, M., P. Munoz, C. V. Mura, and M. T. Nunez. 2003. Dmt1, a physiologically relevant apical Cu1+ transporter of intestinal cells. Am. J. Physiol. Cell Physiol. 284:C1525-C1530.
2. Chen, H., G. Huang, T. Su, H. Gao, Z. K. Attieh, A. T. McKie, G. J. Anderson, and C. D. Vulpe. 2006. Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency. J. Nutr. 136:1236-1241.
3. Chua, A. C., and E. H. Morgan. 1997. Manganese metabolism is impaired in the Belgrade laboratory rat. J. Comp. Physiol. [B] 167:361-369.
4. De Domenico, I., D. Mcvey Ward, M. C. Bonaccorsi di Patti, S. Y. Jeong, S. David, G. Musci, and J. Kaplan. 2007. Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. EMBO J. 26:2823-2831.
5. De Domenico, I., D. Mcvey Ward, and J. Kaplan. 2008. Regulation of iron acquisition and storage: Consequences for iron-linked disorders. Natl. Rev. 9:72-81.
6. Engle, T. E., and J. W. Spears. 2000. Effects of dietary copper concentration and source on performance and copper status of growing and finishing steers. J. Anim. Sci. 78:2446-2451.
7. Frazer, D. M., S. J. Wilkins, E. M. Becker, T. L. Murphy, C. D. Vulpe, A. T. McKie, and G. J. Anderson. 2003. A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption. Gut 52:340-346.
8. Garrick, M. D., H. C. Kuo, F. Varga, S. Singleton, L. Zhao, J. Smith, P. Paradkar, J. A. Roth, and L. M. Garrick. 2006. Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion. Bio- chem. J. 398:539-546.
9. Gengelbach, G. P., J. D. Ward, and J. W. Spears. 1994. Effect of dietary copper, iron and molybdenum on growth and copper status of beef cows and calves. J. Anim. Sci. 72:2722-2727.
10. Grace, N. D. 1973. Effect of high dietary Mn levels on the growth rate and the level of mineral elements in the plasma and soft tissues of sheep. N. Z. J. Agric. Res. 16:177-180.
11. Gunshin, H., B. Mackenzie, U. V. Berger, Y. Gunshin, M. F. Romero, W. F. Boron, S. Nussberger, J. L. Gollan, and M. A. Hediger. 1997. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388:482-488.
12. Hansen, S. L., M. S. Ashwell, L. R. Legleiter, R. S. Fry, K. E. Lloyd, and J. W. Spears. 2009. The addition of high manganese to a copper-deficient diet further depresses copper status and growth of cattle. Br. J. Nutr. 101:1068-1078.
13. Hansen, S. L., P. Schlegel, L. R. Legleiter, K. E. Lloyd, and J. W. Spears. 2008. Bioavailability of copper from copper glycinate in steers fed high dietary sulfur and molybdenum. J. Anim. Sci. 86:173-179.
14. Hartman, R. H., G. Matrone, and G. H. Wise. 1955. Effect of high dietary manganese on hemoglobin formation. J. Nutr. 57:429-439.
15. Janovick-Guretzky, N. A., H. M. Dann, D. B. Carlson, M. R. Murphy, J. J. Loor, and J. K. Drackley. 2007. Housekeeping gene expression in bovine liver is affected by physiological state, feed intake, and dietary treatment. J. Dairy Sci. 90:2246-2252.
16. Johnson, D. M., S. Yamaji, J. Tennant, S. K. Srai, and P. A. Sharp. 2005. Regulation of divalent metal transporter expression in human intestinal epithelial cells following exposure to non-haem iron. FEBS Lett. 579:1923-1929.
17. Legleiter, L. R., H. C. Liu, K. E. Lloyd, S. L. Hansen, R. S. Fry, and J. W. Spears. 2007. Exposure to low dietary copper or low copper coupled with high dietary manganese for one year does not alter brain prion protein characteristics in the mature bovine. J. Anim. Sci. 85:2895-2903.
18. Legleiter, L. R., J. W. Spears, and H. C. Liu. 2008. Copper deficiency in the young bovine results in dramatic decreases in brain copper concentration but does not alter brain prion protein biology. J. Anim. Sci. 86:3069-3078.
19. Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods 25:402-408.
20. NRC. 1996. Nutrient Requirements of Beef Cattle. 7th ed. Natl. Acad. Press, Washington, DC.
21. Osaki, S., D. A. Johnson, and E. Frieden. 1971. The mobilization of iron from the perfused mammalian liver by a serum copper enzyme, ferroxidase I. J. Biol. Chem. 246:3018-3023.
22. Puls, R. 1994. Mineral Levels in Animal Health: Diagnostic Data. 2nd ed. Sherpa Int., Clearbrook, British Columbia, Canada.
23. Rossander-Hulten, L., M. Brune, B. Sandstrom, B. Lonnerdal, and L. Hallberg. 1991. Competitive inhibition of iron absorption by manganese and zinc in humans. Am. J. Clin. Nutr. 54:152-156.
24. Sharp, P. 2004. The molecular basis of copper and iron interactions. Proc. Nutr. Soc. 63:563-569.
25. Suttle, N. F. 1991. The interactions between copper, molybdenum, and sulphur in ruminant nutrition. Annu. Rev. Nutr. 11:121-140.
26. USDA. 2000. Serum copper concentrations of U.S. beef cattle. USDA info sheet N308.0200. USDA, Animal and Plant Health Inspection Service, Fort Collins, CO.