Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure

Tissue Engineering - Part A

Volumn 15, Issue 11, 2009, Pages 3377-3388

  Yagi, Hiroshi ^a,b   Parekkadan, Biju ^a   Suganuma, Kazuhiro ^b   Soto Gutierrez, Alejandro ^a   Tompkins, Ronald G ^a   Tilles, Arno W ^a   Yarmush, Martin L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CELL CULTURE; CELL DEATH; LIVER; SELF ASSEMBLY;

ACUTE LIVER FAILURE; ACUTE-PHASE RESPONSE; ANTI-INFLAMMATORIES; APOPTOSIS; BENEFICIAL EFFECTS; CELL MASS; CELL-BASED; CELLULAR COMPOSITION; CO-CULTURES; COCULTURE; CYTOKINES; DESTINATION THERAPY; HEPATOCELLULAR; HEPATOCYTES; HISTOLOGICAL PARAMETERS; IN-VITRO; INFLAMMATORY CONDITIONS; LIVER ASSIST DEVICE; MESENCHYMAL STEM CELL; ORDER OF MAGNITUDE; ORGAN FUNCTIONS; SECRETOME; THERAPEUTIC EFFECTS;

FLOWCHARTING;

CYTOKINE;

ACUTE PHASE RESPONSE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BIOREACTOR; BLOOD LEVEL; CELL FUNCTION; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; DEVICE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; INFLAMMATION; LIVER ASSIST DEVICE; LIVER CELL; LIVER FAILURE; LIVER FUNCTION; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SEROLOGY; SURVIVAL TIME; THERAPY EFFECT;

RATTUS;

EID: 72649101116     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2008.0681     Document Type: Article

References (36)

1. Lee, W.M. Acute liver failure in the United States. Semin Liver Dis 23, 217, 2003.
2. Fasolato, S., Angeli, P., Dallagnese, L., Maresio, G., Zola, E., Mazza, E., Salinas, F., Donà, S., Fagiuoli, S., Sticca, A., Zanus, G., Cillo, U., Frasson, I., Destro, C., and Gatta, A. Renal failure and bacterial infections in patients with cirrhosis: epidemiology and clinical features. Hepatology 45, 223, 2007.
3. Bruzzone, P., and Strom, S.C. Historical aspects of hepato-cyte transplantation. Transplant Proc 38, 1179, 2006.
4. Griffith, L.G., and Swartz, M.A. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7, 211, 2006.
5. Langer, R., and Vacant, J.P. Tissue engineering. Science 260, 920, 1993.
6. Millis, J.M., and Losanoff, J.E. Technology insight: liver support systems. Nat Clin Pract Gastroenterol Hepatol 2, 398, quiz 434, 2005.
7. Demetriou, A.A., Brown, R.S., Jr., Busuttil, R.W., Fair, J., McGuire, B.M., Rosenthal, P., Am Esch, J.S., II, Lerut, J., Nyberg, S.L., Salizzoni, M., Fagan, E.A., de Hemptinne, B., Broelsch, C.E., Muraca, M., Salmeron, J.M., Rabkin, J.M., Metselaar, H.J., Pratt, D., De La Mata, M., McChesney, L.P., Everson, G.T., Lavin, P.T., Stevens, A.C., Pitkin, Z., and Solomon, B.A. Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure. Ann Surg 239, 660, discussion 667, 2004.
8. Sauer, I.M., Kardassis, D., Zeillinger, K., Pascher, A., Gruenwald, A., Pless, G., Irgang, M., Kraemer, M., Puhl, G., Frank, J., Mü ller, A.R., Steinmü ller, T., Denner, J., Neuhaus, P., and Gerlach, J.C. Clinical extracorporeal hybrid liver support-phase I study with primary porcine liver cells. Xenotransplantation 10, 460, 2003.
9. Mundt, A., Puhl, G., Mü ller, A., Sauer, I., Mü ller, C., Richard, R., Fotopoulou, C., Doll, R., Gäbelein, G., Höhn, W., Hofbauer, R., Neuhaus, P., and Gerlach, J. A method to assess biochemical activity of liver cells during clinical application of extracorporeal hybrid liver support. Int J Artif Organs 25, 542, 2002.
10. Kuddus, R., Patzer, J.F., II, Lopez, R., Mazariegos, G.V., Meighen, B., Kramer, D.J., and Rao, A.S. Clinical and laboratory evaluation of the safety of a bioartificial liver assist device for potential transmission of porcine endogenous retrovirus. Transplantation 73, 420, 2002.
11. Mazariegos, G.V., Kramer, D.J., Lopez, R.C., Shakil, A.O., Rosenbloom, A.J., DeVera, M., Giraldo, M., Grogan, T.A., Zhu, Y., Fulmer, M.L., Amiot, B.P., and Patzer, J.F. Safety observations in phase I clinical evaluation of the Excorp Medical Bioartificial Liver Support System after the first four patients. ASAIO J 47, 471, 2001.
12. Sosef, M.N., Abrahamse, L.S., van de Kerkhove, M.P., Hartman, R., Chamuleau, R.A., and van Gulik, T.M. First report of cryopreserved human hepatocytes based bioartifi-cial liver successfully used as a bridge to liver transplantation. Am J Transplant 4, 286, 2004.
13. Kjaergard, L.L., Liu, J., Als-Nielsen, B., and Gluud, C. Artificial and bioartificial support systems for acute and acute-on-chronic liver failure: a systematic review. JAMA 289, 217, 2003.
14. Cho, C.H., Berthiaume, F., Tilles, A.W., and Yarmush, M.L. A new technique for primary hepatocyte expansion in vitro. Biotechnol Bioeng, 101, 345, 2008.
15. Nahmias, Y., Casali, M., Barbe, L., Berthiaume, F., and Yarmush, M.L. Liver endothelial cells promote LDL-R expression and the uptake of HCV-like particles in primary rat and human hepatocytes. Hepatology 43, 257, 2006.
16. Bhatia, S.N., Balis, U.J., Yarmush, M.L., and Toner, M. Probing heterotypic cell interactions: hepatocyte function in microfabricated co-cultures. J Biomater Sci Polym Ed 9, 1137, 1998.
17. Shinoda, M., Tilles, A.W., Wakabayashi, G., Takayanagi, A., Harada, H., Obara, H., Suganuma, K., Berthiaume, F., Shi-mazu, M., Shimizu, N., Kitajima, M., Tompkins, R.G., Toner, M., and Yarmush, M.L. Treatment of fulminant hepatic failure in rats using a bioartificial liver device containing porcine hepatocytes producing interleukin-1 receptor antagonist. Tissue Eng 12, 1313, 2006.
18. Shito, M., Tilles, A.W., Tompkins, R.G., Yarmush, M.L., and Toner, M. Efficacy of an extracorporeal flat-plate bioartificial liver in treating fulminant hepatic failure. J Surg Res 111, 53, 2003.
19. Shinoda, M., Tilles, A.W., Kobayashi, N., Wakabayashi, G., Takayanagi, A., Totsugawa, T., Harada, H., Obara, H., Su-ganuma, K., Berthiaume, F., Shimazu, M., Shimizu, N., Ta-naka, N., Kitajima, M., Tompkins, R.G., Toner, M., and Yarmush, M.L. A bioartificial liver device secreting inter-leukin-1 receptor antagonist for the treatment of hepatic failure in rats. J Surg Res 137, 130, 2007.
20. Parekkadan, B., van Poll, D., Suganuma, K., Carter, E.A., Berthiaume, F., Tilles, A.W., and Yarmush, M.L. Mesench-ymal stem cell-derived molecules reverse fulminant hepatic failure. PLoS ONE 2, e941, 2007.
21. van Poll, D., Parekkadan, B., Cho, C.H., Berthiaume, F., Nahmias, Y., Tilles, A.W., and Yarmush, M.L. Mesenchymal stem cell-derived molecules directly modulate hepatocellu-lar death and regeneration in vitro and in vivo. Hepatology 47, 1634, 2008.
22. Dunn, J.C., Yarmush, M.L., Koebe, H.G., and Tompkins, R.G. Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration. FASEB J 3, 174, 1989.
23. Parrekadan, B., van Poll, D., Megeed, Z., Kobayashi, N., Tilles, A.W., Berthiaume, F., and Yarmush, M.L. Im-munomodulation of activated hepatic stellate cells by me-senchymal stem cells. Biochem Biophys Res Commun 363, 247, 2007.
24. Behnia, K., Bhatia, S., Jastromb, N., Balis, U., Sullivan, S., Yarmush, M., and Toner, M. Xenobiotic metabolism by cultured primary porcine hepatocytes. Tissue Eng 6, 467, 2000.
25. Banas, A., Teratani, T., Yamamoto, Y., Tokuhara, M., Take-shita, F., Quinn, G., Okochi, H., and Ochiya, T. Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. Hepatology 46, 219, 2007.
26. Lee, K.D., Kuo, T.K., Whang-Peng, J., Chung, Y.F., Lin, C.T., Chou, S.H., Chen, J.R., Chen, Y.P., and Lee, O.K. In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 40, 1275, 2004.
27. Maezono, K., Mawatari, K., Kajiwara, K., Shinkai, A., and Maki, T. Effect of alanine on D-galactosamine-induced acute liver failure in rats. Hepatology 24, 1211, 1996.
28. Jayaraman, A., Yarmush, M.L., and Roth, C.M. Evaluation of an in vitro model of hepatic inflammatory response by gene expression profiling. Tissue Eng 11, 50, 2005.
29. Gnecchi, M., He, H., Liang, O.D., Melo, L.G., Morello, F., Mu, H., Noiseux, N., Zhang, L., Pratt, R.E., Ingwall, J.S., and Dzau, V.J. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 11, 367, 2005.
30. Gnecchi, M., He, H., Noiseux, N., Liang, O.D., Zhang, L., Morello, F., Mu, H., Melo, L.G., Pratt, R.E., Ingwall, J.S., and Dzau, V.J. Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J 20, 661, 2006.
31. Ortiz, L.A., Dutreil, M., Fattman, C., Pandey, A.C., Torres, G., Go, K., and Phinney, D.G. Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci USA 104, 11002, 2007.
32. Togel, F., Weiss, K., Yang, Y., Hu, Z., Zhang, P., and Wes-tenfelder, C. Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. Am J Physiol Renal Physiol 292, F1626, 2007.
33. Khetani, S.R., and Bhatia, S.N. Microscale culture of human liver cells for drug development. Nat Biotechnol 26, 120, 2008.
34. Khetani, S.R., Szulgit, G., Del Rio, J.A., Barlow, C., and Bhatia, S.N. Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling. Hepatology 40, 545, 2004.
35. Isoda, K., Kojima, M., Takeda, M., Higashiyama, S., Kawase, M., and Yagi, K. Maintenance of hepatocyte functions by coculture with bone marrow stromal cells. J Biosci Bioeng 97, 343, 2004.
36. Silverstein, R. D-galactosamine lethality model: scope and limitations. J Endotoxin Res 10, 147, 2004.