Revisiting delta-6 desaturase regulation by C18 unsaturated fatty acids, depending on the nutritional status

Biochimie

Volumn 91, Issue 11-12, 2009, Pages 1443-1449

  Skrzypski, Jérémy ^a   Bellenger, Sandrine ^a   Bellenger, Jérôme ^a   Sinclair, Andrew ^c   Poisson, Jean Pierre ^b   Tessier, Christian ^a   Rialland, Mickaël ^a   Narce, Michel ^a  

^a Chu   (France)

^b UNIVERSITÉ DE BOURGOGNE   (France)

^c DEAKIN UNIVERSITY   (Australia)

Author keywords

Alpha linolenic acid; Delta 6 desaturation; Dietary fatty acids; Linoleic acid; Liver lipids; Oleic acid

Indexed keywords

LINOLEIC ACID; LINOLENIC ACID; LINOLEOYL COENZYME A DESATURASE; MESSENGER RNA; OLEIC ACID; STARCH; UNSATURATED FATTY ACID; VEGETABLE OIL;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SPECIFICITY; FAT INTAKE; FATTY ACID DESATURATION; GENE EXPRESSION REGULATION; LIPID LIVER LEVEL; MALE; NONHUMAN; NUTRITIONAL STATUS; RAT; WISTAR RAT;

ANIMALS; DIETARY FATS; FATTY ACIDS, OMEGA-3; FATTY ACIDS, UNSATURATED; GENE EXPRESSION REGULATION; HUMANS; LINOLEOYL-COA DESATURASE; RATS; RATS, WISTAR;

RATTUS NORVEGICUS;

EID: 72649094599     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2009.08.001     Document Type: Article

References (30)

1. Duplus E., Glorian M., and Forest C. Fatty acid regulation of gene transcription. J. Biol. Chem. 275 (2000) 30749-30752
2. Cho H.P., Nakamura M.T., and Clarke S.D. Cloning, expression, and nutritional regulation of the mammalian Δ-6 desaturase. J. Biol. Chem. 274 (1999) 471-477
3. Fujiwara Y., Okayasu T., Ishibashi T., and Imai Y. Immunochemical evidence for the enzymatic difference of delta 6-desaturase from delta 9- and delta 5-desaturase in rat liver microsomes. Biochem. Biophys. Res. Commun. 110 (1983) 36-41
4. Brenner R.R. Factors affecting fatty acid chain elongation and desaturation. In: Vergroesen A.J., and Crawford M.A. (Eds). The Role of Fats in Human Nutrition. second ed. (1989), Academic Press, San Diego 45-80
5. Cho H.P., Nakamura M.T., and Clarke S.D. Cloning, expression, and nutritional regulation of the human Δ-5 desaturase. J. Biol. Chem. 274 (1999) 37335-37339
6. Miyazaki M., and Ntambi J.M. Role of stearoyl-coenzyme A desaturase in lipid metabolism. Prostaglandins Leukot. Essent. Fatty Acids 68 (2003) 113-121
7. Hoy C.E., Holmer G., Kaur N., Byrjalsem I., and Kirstein D. Acyl group distributions in tissue lipids of rats fed evening primrose oil (γ-linolenic plus linoleic acid) or soybean oil (α-linolenic plus linoleic acid). Lipids 18 (1983) 760-771
8. Blond J.P., and Lemarchal P. A study of the effect of α-linolenic acid on the desaturation of dihomo-γ-linolenic acid using rat liver homogenates. Reprod. Nutr. Dev. 24 (1984) 1-10
9. Garg M.L., Sebokova E., Thomson A.B.R., and Clandinin M.T. Δ6 desaturase activity in liver microsomes of rats fed diets enriched with cholesterol and/or ω3 fatty acids. Biochem. J. 249 (1988) 351-356
10. Garg M.L., Sebokova E., Thomson A.B.R., and Clandinin M.T. Effect of dietary cholesterol and/or ω3 fatty acids on lipid composition and Δ5-desaturase activity. J. Nutr. 118 (1988) 661-668
11. Christiansen E.N., Lund J.S., Rortveit T., and Rustan A.C. Effect of dietary n-3 and n-6 fatty acid desaturation in rat liver. Biochim. Biophys. Acta 1082 (1991) 57-62
12. Bellenger-Germain S., Poisson J.P., and Narce M. Antihypertensive effects of a dietary unsaturated FA mixture in spontaneously hypertensive rats. Lipids 37 (2002) 561-567
13. Narce M., Asdrubal P., Delachambre M.C., Véricel E., Lagarde M., and Poisson J.P. Age-related changes in linoleic acid bioconversion by isolated hepatocytes from spontaneously hypertensive and normotensive rats. Mol. Cell Biochem. 141 (1994) 9-13
14. Hagve T.A., Woldseth B., Brox J., Narce M., and Poisson J.P. Membrane fluidity and fatty acid metabolism in kidney cells from rats fed purified eicosapentaenoic acid or purified docosahexaenoic acid. Scand. J. Clin. Lab. Invest. 58 (1998) 187-194
15. Slover H.T., and Lanza E.J. Quantitative analysis of food fatty acids by capillarity gas chromatography. J. Am. Oil Chem. Soc. 56 (1979) 933-943
16. Poisson J.P., Huang Y.S., Mills D.E., de Antueno R.J., Redden P.R., Lin X., Narce M., and Horrobin D.F. Effect of salt-loading and spontaneous hypertension on in vitro metabolism of [1-14C]linoleic and [2-14C] dihomo-gamma-linolenic acids. Biochem. Med. Metab. Biol. 49 (1993) 57-66
17. Engler M.M., Bellenger-Germain S.H., Engler M.B., Narce M.M., and Poisson J.P. Dietary docosahexaenoic acid affects stearic acid desaturation in spontaneously hypertensive rats. Lipids 35 (2000) 1011-1015
18. Comte C., Bellenger S., Bellenger J., Tessier C., Poisson J.P., and Narce M. Effects of streptozotocin and dietary fructose on delta-6 desaturation in spontaneously hypertensive rat liver. Biochimie 86 (2004) 799-806
19. Narce M., Asdrubal P., Delachambre M.C., Gresti J., and Poisson J.P. Influence of spontaneous hypertension on n-3 delta-6-desaturase activity and fatty acid composition of rat hepatocytes. Mol. Cell Biochem. 152 (1995) 7-12
20. Nakamura M.T., Cho H.P., and Clarke S.D. Regulation of hepatic delta-6 desaturase expression and its role in the polyunsaturated fatty acid inhibition of fatty acid synthase gene expression in mice. J. Nutr. 130 (2000) 1561-1565
21. Bezard J., Blond J.P., Bernard A., and Clouet P. Availability of essential fatty acids in animal tissues. Reprod. Nutr. Dev. 34 (1994) 539-568
22. De Antueno R.J., Knickle L.C., Smith H., Elliot M.L., Allen S.J., Nwaka S., and Winther M.D. Activity of human delta 5 and delta 6 desaturase on multiple n-3 and n-6 polyunsaturated fatty acids. FEBS Lett. 509 (2001) 77-80
23. D'Andrea S., Guillou H., Jan S., Catheline D., Thibault J.N., Bouriel M., Rioux V., and Legrand P. The same Δ6-desaturase not only acts on 18- but also 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis. Biochem. J. 364 (2002) 49-55
24. Marzo I., Alava M.A., Piñeiro A., and Naval J. Biosynthesis of docosahexaenoic acid in human cells: evidence that two different delta 6-desaturase activities may exist. Biochim. Biophys. Acta 1301 (1996) 263-272
25. Rodriguez A., Sarda P., Boulot P., Leger C.L., and Descomps B. Differential effect of N-ethyl maleimide on delta6-desaturase activity in human fetal liver toward fatty acids of the n-6 and n-3 series. Lipids 34 (1999) 23-30
26. Inagaki K., Aki T., Shiota T., Kawamoto S., Shigeta S., Suzuki O., and Ono K. Evidence of isoenzymes for Δ6 fatty acid desaturase in rat hepatocytes. Biosci. Biotechnol. Biochem. 67 (2002) 451-454
27. Infante J.P., and Huszagh V.A. Analysis of the putative role of 24-carbon fatty acids in the biosynthesis of docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids. FEBS Lett. 431 (1998) 1-6
28. Brenner R.R., Rimoldi O.J., Lombardo Y.B., González M.S., Bernasconi A.M., Chicco A., and Basabe J.C. Desaturase activities in rat model of insulin resistance induced by a sucrose-rich diet. Lipids 38 (2003) 733-742
29. Barceló-Coblijn G., Collison L.W., Jolly C.A., and Murphy E.J. Dietary alpha-linolenic acid increases brain but not heart and liver docosahexaenoic acid levels. Lipids 40 (2005) 787-798
30. Bellenger J., Bellenger S., Clément L., Mandard S., Diot C., Poisson J.P., and Narce M. A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl CoA desaturase 1 gene expression in the SHR model of genetic hypertension. FASEB J. 18 (2004) 773-775