Th17/Tc17 infiltration and associated cytokine gene expression in elicitation phase of allergic contact dermatitis

British Journal of Dermatology

Volumn 161, Issue 6, 2009, Pages 1301-1306

  Zhao, Y ^a,b   Balato, A ^c   Fishelevich, R ^a   Chapoval, A ^a   Mann, D L ^a   Gaspari, A A ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b CHINA MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Allergic contact dermatitis; Interleukin 17; Patch test; RORC; Th17 lymphocytes

Indexed keywords

ALLERGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 23; INTERLEUKIN 4; MESSENGER RNA; TRANSCRIPTION FACTOR;

ADULT; AGED; ALLERGIC REACTION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE EXPRESSION; HUMAN; IMMUNOFLUORESCENCE; MALE; PATCH TEST; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SKIN ALLERGY; SKIN BIOPSY; SKIN INFILTRATE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL;

ADULT; AGED; DERMATITIS, ALLERGIC CONTACT; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; HUMANS; IMMUNITY, CELLULAR; INTERLEUKIN-17; MALE; MIDDLE AGED; PATCH TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTE SUBSETS;

EID: 72649083292     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2009.09400.x     Document Type: Article

References (21)

1. Gober MD, Gaspari AA. Allergic contact dermatitis. Curr Dir Autoimmun 2008 10 : 1 26.
2. Kerfoot SM, Szczepanik M, Tung JW et al. Identification of initiator B cells, a novel subset of activation-induced deaminase-dependent B-1-like cells that mediate initiation of contact sensitivity. J Immunol 2008 181 : 1717 1727.
3. Gober MD, Fishelevich R, Zhao Y et al. Human natural killer T cells infiltrate into the skin at elicitation sites of allergic contact dermatitis. J Invest Dermatol 2008 128 : 1460 1469.
4. Bettelli E, Korn T, Oukka M et al. Induction and effector functions of T(H)17 cells. Nature 2008 453 : 1051 1057.
5. van Beelen AJ, Teunissen MB, Kapsenberg ML et al. Interleukin-17 in inflammatory skin disorders. Curr Opin Allergy Clin Immunol 2007 7 : 374 381.
6. Albanesi C, Scarponi C, Cavani A et al. Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes. J Invest Dermatol 2000 115 : 81 7.
7. Nakae S, Komiyama Y, Nambu A et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 2002 17 : 375 387.
8. Oboki K, Ohno T, Saito H et al. Th17 and allergy. Allergol Int 2008 57 : 121 134.
9. Belsito DV. Patch testing with a standard allergen ('screening') tray: rewards and risks. Dermatol Ther 2004 17 : 231 239.
10. Zhao Y, Fishelevich R, Petrali JP et al. Activation of keratinocyte protein kinase C zeta in psoriasis plaques. J Invest Dermatol 2008 128 : 2190 2197.
11. Ouyang W, Kolls JK, Zheng Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 2008 28 : 454 467.
12. Singh SP, Zhang HH, Foley JF et al. Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J Immunol 2008 180 : 214 221.
13. Lechner A, Ritter U, Varona R et al. Protective immunity and delayed type hypersensitivity reaction are uncoupled in experimental Leishmania major infection of CCR6-negative mice. Microbes Infect 2007 9 : 291 299.
14. Steinman L. A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med 2007 13 : 139 145.
15. Ivanov II, McKenzie BS, Zhou L et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006 126 : 1121 1133.
16. Ichiyama K, Yoshida H, Wakabayashi Y et al. Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. J Biol Chem 2008 283 : 17003 17008.
17. Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 2008 9 : 641 649.
18. He D, Wu L, Kim HK et al. CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. J Immunol 2006 177 : 6852 6858.
19. Mestas J, Hughes CC. Of mice and not men: differences between mouse and human immunology. J Immunol 2004 172 : 2731 2738.
20. Ghilardi N, Kljavin N, Chen Q et al. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J Immunol 2004 172 : 2827 2833.
21. Gu Y, Yang J, Ouyang X et al. Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells. Eur J Immunol 2008 38 : 1807 1813.