-
1
-
-
41849150003
-
Metastasis: A therapeutic target for cancer
-
Steeg PS. Metastasis: a therapeutic target for cancer. Nat Clin Prac Oncol 2008;5(4):206-219
-
(2008)
Nat Clin Prac Oncol
, vol.5
, Issue.4
, pp. 206-219
-
-
Steeg, P.S.1
-
2
-
-
0029166671
-
Rho Rac and Cdc42 GTPases: Regulators of actin structures, cell adhesion and motility
-
Nobes CD, Hall A. Rho, Rac and Cdc42 GTPases: regulators of actin structures, cell adhesion and motility. Biochem Soc Trans 1995;23(3):456-459
-
(1995)
Biochem Soc Trans
, vol.23
, Issue.3
, pp. 456-459
-
-
Nobes, C.D.1
Hall, A.2
-
3
-
-
0035836791
-
Rho signals to cell growth and apoptosis
-
Aznar S, Lacal JC. Rho signals to cell growth and apoptosis. Cancer Lett 2001;165(1):1-10
-
(2001)
Cancer Lett
, vol.165
, Issue.1
, pp. 1-10
-
-
Aznar, S.1
Lacal, J.C.2
-
4
-
-
44449178868
-
RhoGTPases in cancer cell biology
-
Vega FM, Ridley AJ. RhoGTPases in cancer cell biology. FEBS Lett 2008;582(14):2093-2101
-
(2008)
FEBS Lett
, vol.582
, Issue.14
, pp. 2093-2101
-
-
Vega, F.M.1
Ridley, A.J.2
-
5
-
-
0037069690
-
Rho GTPases in cell biology
-
Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002;420(6916):629-635
-
(2002)
Nature
, vol.420
, Issue.6916
, pp. 629-635
-
-
Etienne-Manneville, S.1
Hall, A.2
-
6
-
-
21244478650
-
Rho GTPase expression in tumourigenesis: Evidence for a significant link
-
Gomez del Pulgar T, Benitah SA, Valeron PF, et al. Rho GTPase expression in tumourigenesis: evidence for a significant link. Bioessays 2005;27(6):602-613
-
(2005)
Bioessays
, vol.27
, Issue.6
, pp. 602-613
-
-
Gomez Del Pulgar, T.1
Benitah, S.A.2
Valeron, P.F.3
-
7
-
-
0034213327
-
RhoGTPases and their effector proteins
-
Bishop AL, Hall A. RhoGTPases and their effector proteins. Biochem J 2000;348(Pt 2):241-255
-
(2000)
Biochem J
, vol.348
, Issue.PART 2
, pp. 241-255
-
-
Bishop, A.L.1
Hall, A.2
-
8
-
-
0036644975
-
Guanine nucleotide exchange factors for Rho GTPases: Turning on the switch
-
Schmidt A, Hall A. Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev 2002;16(13):1587-1609
-
(2002)
Genes Dev
, vol.16
, Issue.13
, pp. 1587-1609
-
-
Schmidt, A.1
Hall, A.2
-
9
-
-
0037213689
-
Rho GTPase-activation proteins in cell regulation
-
Moon SY, Zheng Y. Rho GTPase-activation proteins in cell regulation. Trends Cell Biol 2003;13(1):13-22
-
(2003)
Trends Cell Biol
, vol.13
, Issue.1
, pp. 13-22
-
-
Moon, S.Y.1
Zheng, Y.2
-
10
-
-
0025295180
-
Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20; A ras p21-like GTP-binding protein
-
Ueda T, Kikuchi A, Ohga N, et al. Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20; a ras p21-like GTP-binding protein. J Biol Chem 1990;265(16):9373-9380
-
(1990)
J Biol Chem
, vol.265
, Issue.16
, pp. 9373-9380
-
-
Ueda, T.1
Kikuchi, A.2
Ohga, N.3
-
11
-
-
0025073547
-
Molecular cloning and characterization of novel type of regulatory protein (GDI) for the Rho proteins, ras p21-like small GTP-binding proteins
-
Fukumoto Y, Kaibuchi K, Hori Y, et al. Molecular cloning and characterization of novel type of regulatory protein (GDI) for the Rho proteins, ras p21-like small GTP-binding proteins. Oncogene 1990;5(9):1321-1328
-
(1990)
Oncogene
, vol.5
, Issue.9
, pp. 1321-1328
-
-
Fukumoto, Y.1
Kaibuchi, K.2
Hori, Y.3
-
12
-
-
23944518413
-
RhoGDI: Multiple functions in the regulation of Rho family GTPase activities
-
Dovas A, Couchman JR. RhoGDI: multiple functions in the regulation of Rho family GTPase activities. Biochem J 2005;390(Pt1):1-9
-
(2005)
Biochem J
, vol.390
, Issue.PART1
, pp. 1-9
-
-
Dovas, A.1
Couchman, J.R.2
-
13
-
-
0033058184
-
Rho guanine dissociation inhibitors: Pivotal molecules in cellular signalling
-
Olofsson B. Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling. Cell Signal 1999;11(8):545-554
-
(1999)
Cell Signal
, vol.11
, Issue.8
, pp. 545-554
-
-
Olofsson, B.1
-
14
-
-
0026475383
-
The identification and characterization of a GDP-dissociation inhibitor (GDI) for the Cdc42Hs proteins
-
Leonard D, Hart M, Platko J, et al. The identification and characterization of a GDP-dissociation inhibitor (GDI) for the Cdc42Hs proteins. J Biol Chem 1992;267(32):22860-22868
-
(1992)
J Biol Chem
, vol.267
, Issue.32
, pp. 22860-22868
-
-
Leonard, D.1
Hart, M.2
Platko, J.3
-
15
-
-
0029828539
-
RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG
-
Zalcman G, Closson V, Camonis J, et al. RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. J Biol Chem 1996;271(48):30366-30374
-
(1996)
J Biol Chem
, vol.271
, Issue.48
, pp. 30366-30374
-
-
Zalcman, G.1
Closson, V.2
Camonis, J.3
-
16
-
-
0030611196
-
RhoGDIgamma: A GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas
-
Adra CN, Manor D, Ko JL, et al. RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas. Proc Natl Acad Sci 1997;94(9):4279-4284
-
(1997)
Proc Natl Acad Sci
, vol.94
, Issue.9
, pp. 4279-4284
-
-
Adra, C.N.1
Manor, D.2
Ko, J.L.3
-
17
-
-
0027526303
-
CDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the Rho GTP-binding proteins
-
Lelias JM, Adra CN, Wulf GM, et al. cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the Rho GTP-binding proteins. Proc Natl Acad Sci 1993;90(4):1479-1483
-
(1993)
Proc Natl Acad Sci
, vol.90
, Issue.4
, pp. 1479-1483
-
-
Lelias, J.M.1
Adra, C.N.2
Wulf, G.M.3
-
18
-
-
0027237511
-
Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes
-
Scherle P, Behrens T, Staudt LM. Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. Proc Natl Acad Sci 1993;90(16):7568-7572
-
(1993)
Proc Natl Acad Sci
, vol.90
, Issue.16
, pp. 7568-7572
-
-
Scherle, P.1
Behrens, T.2
Staudt, L.M.3
-
19
-
-
21744432683
-
GDIs: Central regulatory molecules in Rho GTPase activation
-
DerMardirossian C, Bokoch GM. GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol 2005;15(7):356-363
-
(2005)
Trends Cell Biol
, vol.15
, Issue.7
, pp. 356-363
-
-
Dermardirossian, C.1
Bokoch, G.M.2
-
20
-
-
23944518413
-
RhoGDI: Multiple functions in the regulation of Rho family GTPase activities
-
Dovas A, Couchman JR. RhoGDI: multiple functions in the regulation of Rho family GTPase activities. Biochem J 2005;390(Pt 1):1-9
-
(2005)
Biochem J
, vol.390
, Issue.PART 1
, pp. 1-9
-
-
Dovas, A.1
Couchman, J.R.2
-
21
-
-
26944440432
-
RhoGDIs revisited: Novel roles in Rho regulation
-
Dransart E, Olofsson B, Cherfils J. RhoGDIs revisited: novel roles in Rho regulation. Traffic 2005;6(11):957-966
-
(2005)
Traffic
, vol.6
, Issue.11
, pp. 957-966
-
-
Dransart, E.1
Olofsson, B.2
Cherfils, J.3
-
22
-
-
33747797000
-
Rho GDP dissociation inhibitors as potential targets for anticancer treatment
-
Zhang B. Rho GDP dissociation inhibitors as potential targets for anticancer treatment. Drug Resist Updat 2006;9(3):134-141
-
(2006)
Drug Resist Updat
, vol.9
, Issue.3
, pp. 134-141
-
-
Zhang, B.1
-
23
-
-
0035808306
-
Structure- activity relationships in flexible protein domains: Regulation of rho GTPases by RhoGDI and D4 GDI
-
Golovanov AP, Chuang TH, DerMardirossian C, et al. Structure- activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI. J Mol Biol 2001;305(1):121-135
-
(2001)
J Mol Biol
, vol.305
, Issue.1
, pp. 121-135
-
-
Golovanov, A.P.1
Chuang, T.H.2
Dermardirossian, C.3
-
25
-
-
0035964281
-
Crystal structure of the Rac1 - RhoGDI complex involved in NADPH oxidase activation
-
DOI 10.1021/bi010288k
-
Grizot S, Fauré J, Fieschi F, et al. Crystal structure of the Rac1-RhoGDI complex involved in NADPH oxidase activation. Biochemistry 2001;40(34):10007-10013 (Pubitemid 32800107)
-
(2001)
Biochemistry
, vol.40
, Issue.34
, pp. 10007-10013
-
-
Grizot, S.1
Faure, J.2
Fieschi, F.3
Vignais, P.V.4
Dagher, M.-C.5
Pebay-Peyroula, E.6
-
26
-
-
0034603198
-
Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI
-
Hoffman GR, Nassar N, Cerione RA. Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI. Cell 2000;100(3):345-356
-
(2000)
Cell
, vol.100
, Issue.3
, pp. 345-356
-
-
Hoffman, G.R.1
Nassar, N.2
Cerione, R.A.3
-
27
-
-
0343750716
-
The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI
-
Scheffzek K, Stephan I, Jensen ON, et al. The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. Nat Struct Biol 2000;7(2):122-126
-
(2000)
Nat Struct Biol
, vol.7
, Issue.2
, pp. 122-126
-
-
Scheffzek, K.1
Stephan, I.2
Jensen, O.N.3
-
28
-
-
0035834388
-
The guanine nucleotide-binding switch in three dimensions
-
Vetter IR, Wittinghofer A. The guanine nucleotide-binding switch in three dimensions. Science 2001;294(5545):1299-1304
-
(2001)
Science
, vol.294
, Issue.5545
, pp. 1299-1304
-
-
Vetter, I.R.1
Wittinghofer, A.2
-
29
-
-
0031570337
-
A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm
-
Keep NH, Barnes M, Barsukov I, et al. A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm. Structure 1997;5(5):623-633
-
(1997)
Structure
, vol.5
, Issue.5
, pp. 623-633
-
-
Keep, N.H.1
Barnes, M.2
Barsukov, I.3
-
30
-
-
0030992879
-
C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases
-
Gosser YQ, Nomanbhoy TK, Aghazadeh B, et al. C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases. Nature 1997;387(6635):814-819
-
(1997)
Nature
, vol.387
, Issue.6635
, pp. 814-819
-
-
Gosser, Y.Q.1
Nomanbhoy, T.K.2
Aghazadeh, B.3
-
31
-
-
0038363325
-
Dissociation of GDP dissociation inhibitor and membrane translocation are required for efficient activation of Rac by the Dbl homology-pleckstrin homology region of Tiam
-
Robbe K, Otto-Bruc A, Chardin P, et al. Dissociation of GDP dissociation inhibitor and membrane translocation are required for efficient activation of Rac by the Dbl homology-pleckstrin homology region of Tiam. J Biol Chem 2003;278(7):4756-4762
-
(2003)
J Biol Chem
, vol.278
, Issue.7
, pp. 4756-4762
-
-
Robbe, K.1
Otto-Bruc, A.2
Chardin, P.3
-
32
-
-
0035933870
-
Protein kinase C-alpha signals Rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function
-
Mehta D, Rahman A, Malik AB. Protein kinase C-alpha signals Rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function. J Biol Chem 2001;276(25):22614-22620
-
(2001)
J Biol Chem
, vol.276
, Issue.25
, pp. 22614-22620
-
-
Mehta, D.1
Rahman, A.2
Malik, A.B.3
-
33
-
-
3042839349
-
Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase
-
DerMardirossian C, Schnelzer A, Bokoch GM. Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase. Mol Cell 2004;15(1):117-127
-
(2004)
Mol Cell
, vol.15
, Issue.1
, pp. 117-127
-
-
Dermardirossian, C.1
Schnelzer, A.2
Bokoch, G.M.3
-
34
-
-
33750522653
-
Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling
-
DerMardirossian C, Rocklin G, Seo JY, et al. Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling. Mol Biol Cell 2006;17(11):4760-4768
-
(2006)
Mol Biol Cell
, vol.17
, Issue.11
, pp. 4760-4768
-
-
Dermardirossian, C.1
Rocklin, G.2
Seo, J.Y.3
-
35
-
-
0030846295
-
Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/ moesin initiates the activation of the Rho small G protein
-
Takahashi K, Sasaki T, Mammoto A, et al. Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/ moesin initiates the activation of the Rho small G protein. J Biol Chem 1997;272(37):23371-23375
-
(1997)
J Biol Chem
, vol.272
, Issue.37
, pp. 23371-23375
-
-
Takahashi, K.1
Sasaki, T.2
Mammoto, A.3
-
36
-
-
0037119386
-
Selective activation of small GTPase RhoA by tyrosine kinase Etk through its pleckstrin homology domain
-
Kim O, Yang J, Qiu Y. Selective activation of small GTPase RhoA by tyrosine kinase Etk through its pleckstrin homology domain. J Biol Chem 2002;277(33):30066-30071
-
(2002)
J Biol Chem
, vol.277
, Issue.33
, pp. 30066-30071
-
-
Kim, O.1
Yang, J.2
Qiu, Y.3
-
37
-
-
0037408391
-
The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
-
Yamashita T, Tohyama M. The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat Neurosci 2003;6(5):461-467
-
(2003)
Nat Neurosci
, vol.6
, Issue.5
, pp. 461-467
-
-
Yamashita, T.1
Tohyama, M.2
-
38
-
-
0027442667
-
Biologically active lipids are regulators of Rac.GDI complexation
-
Chuang TH, Bohl BP, Bokoch GM. Biologically active lipids are regulators of Rac.GDI complexation. J Biol Chem 1993;268(35):26206-26211
-
(1993)
J Biol Chem
, vol.268
, Issue.35
, pp. 26206-26211
-
-
Chuang, T.H.1
Bohl, B.P.2
Bokoch, G.M.3
-
39
-
-
0001678613
-
Phosphoinositide-dependent activation of Rho A involves partial opening of the RhoA/Rho-GDI complex
-
Fauré J, Vignais PV, Dagher MC. Phosphoinositide-dependent activation of Rho A involves partial opening of the RhoA/Rho-GDI complex. Eur J Biochem 1999;262(3):879-889
-
(1999)
Eur J Biochem
, vol.262
, Issue.3
, pp. 879-889
-
-
Fauré, J.1
Vignais, P.V.2
Dagher, M.C.3
-
40
-
-
0037096169
-
Rho-dependent and -independent activation mechanisms of ezrin/radixin/ moesin proteins: An essential role for polyphosphoinositides in vivo
-
Yonemura S, Matsui T, Tsukita S, et al. Rho-dependent and -independent activation mechanisms of ezrin/radixin/ moesin proteins: an essential role for polyphosphoinositides in vivo. J Cell Sci 2002;115(Pt 12):2569-2580
-
(2002)
J Cell Sci
, vol.115
, Issue.PART 12
, pp. 2569-2580
-
-
Yonemura, S.1
Matsui, T.2
Tsukita, S.3
-
41
-
-
1442285361
-
Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin
-
Fievet BT, Gautreau A, Roy C, et al. Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin. J Cell Biol 2004;164(5):653-659
-
(2004)
J Cell Biol
, vol.164
, Issue.5
, pp. 653-659
-
-
Fievet, B.T.1
Gautreau, A.2
Roy, C.3
-
42
-
-
65249188790
-
Diacylglycerol kinase z regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI
-
Abramovici H, Mojtabaie P, Parks RJ, et al. Diacylglycerol kinase z regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. Mol Biol Cell 2009;20(7):2049-2059
-
(2009)
Mol Biol Cell
, vol.20
, Issue.7
, pp. 2049-2059
-
-
Abramovici, H.1
Mojtabaie, P.2
Parks, R.J.3
-
43
-
-
34848854515
-
Loss of expression of LyGDI (ARHGDIB), a rho GDP-dissociation inhibitor, in Hodgkin lymphoma
-
Ma L, Xu G, Sotnikova A, et al. Loss of expression of LyGDI (ARHGDIB), a rho GDP-dissociation inhibitor, in Hodgkin lymphoma. Br J Haematol 2007;139(2):217-223
-
(2007)
Br J Haematol
, vol.139
, Issue.2
, pp. 217-223
-
-
Ma, L.1
Xu, G.2
Sotnikova, A.3
-
44
-
-
0034842795
-
The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines
-
Seraj MJ, Harding MA, Gildea JJ, et al. The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines. Clin Exp Metastasis 2000;18(6):519-525
-
(2000)
Clin Exp Metastasis
, vol.18
, Issue.6
, pp. 519-525
-
-
Seraj, M.J.1
Harding, M.A.2
Gildea, J.J.3
-
45
-
-
0037112363
-
RhoGDI2 is an invasion and metastasis suppressor gene in human cancer
-
Gildea JJ, Seraj MJ, Oxford G, et al. RhoGDI2 is an invasion and metastasis suppressor gene in human cancer. Cancer Res 2002;62(22):6418-6423
-
(2002)
Cancer Res
, vol.62
, Issue.22
, pp. 6418-6423
-
-
Gildea, J.J.1
Seraj, M.J.2
Oxford, G.3
-
46
-
-
2542606977
-
Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer
-
Theodorescu D, Sapinoso LM, Conaway MR, et al. Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer. Clin Cancer Res 2004;10(11):3800-3806
-
(2004)
Clin Cancer Res
, vol.10
, Issue.11
, pp. 3800-3806
-
-
Theodorescu, D.1
Sapinoso, L.M.2
Conaway, M.R.3
-
47
-
-
23844468385
-
Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2
-
Titus B, Frierson HF Jr, Conaway M, et al. Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2. Cancer Res 2005;65(16):7320-7327
-
(2005)
Cancer Res
, vol.65
, Issue.16
, pp. 7320-7327
-
-
Titus, B.1
Frierson Jr., H.F.2
Conaway, M.3
-
48
-
-
33846846542
-
Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia
-
Wu Y, McRoberts K, Berr SS, et al. Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia. Oncogene 2007;26(5):765-773
-
(2007)
Oncogene
, vol.26
, Issue.5
, pp. 765-773
-
-
Wu, Y.1
McRoberts, K.2
Berr, S.S.3
-
49
-
-
0035397380
-
Changes in gene expression during progression of ovarian carcinoma
-
Tapper J, Kettunen E, El-Rifai W, et al. Changes in gene expression during progression of ovarian carcinoma. Cancer Genet Cytogenet 2001;128(1):1-6
-
(2001)
Cancer Genet Cytogenet
, vol.128
, Issue.1
, pp. 1-6
-
-
Tapper, J.1
Kettunen, E.2
El-Rifai, W.3
-
50
-
-
33745233810
-
D4-GDI, a Rho GTPase regulator, promotes breast cancer cell invasiveness
-
Zhang Y, Zhang B. D4-GDI, a Rho GTPase regulator, promotes breast cancer cell invasiveness. Cancer Res 2006;66(11):5592-5598
-
(2006)
Cancer Res
, vol.66
, Issue.11
, pp. 5592-5598
-
-
Zhang, Y.1
Zhang, B.2
-
51
-
-
67649675530
-
Silencing of D4-GDI inhibits growthand invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling
-
Zhang Y, Rivera Rosado LA, Moon SY, et al. Silencing of D4-GDI inhibits growthand invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling. J Biol Chem 2009;284(19):12956-12965
-
(2009)
J Biol Chem
, vol.284
, Issue.19
, pp. 12956-12965
-
-
Zhang, Y.1
Rivera Rosado, L.A.2
Moon, S.Y.3
-
52
-
-
36348938027
-
Cyclooxygenase-2 is a target gene of rho GDP dissociation inhibitor beta in breast cancer cells
-
Schunke D, Span P, Ronneburg H, et al. Cyclooxygenase-2 is a target gene of rho GDP dissociation inhibitor beta in breast cancer cells. Cancer Res 2007;67(22):10694-10702
-
(2007)
Cancer Res
, vol.67
, Issue.22
, pp. 10694-10702
-
-
Schunke, D.1
Span, P.2
Ronneburg, H.3
-
53
-
-
2942529276
-
The biology of the Ets1 proto-oncogene
-
DOI 10.1186/1476-4598-2-29
-
Dittmer J. The biology of the Ets1 proto-oncogene. Mol Cancer 2003;2:29: published online 20 August 2003, doi:10.1186/1476-4598-2-29 (Pubitemid 38751468)
-
(2003)
Molecular Cancer
, vol.2
, pp. 29
-
-
Dittmer, J.1
-
54
-
-
27544515095
-
ETS transcription factors and their emerging roles in human cancer
-
Seth A, Watson DK. ETS transcription factors and their emerging roles in human cancer. Eur J Cancer 2005;41(16):2462-2478
-
(2005)
Eur J Cancer
, vol.41
, Issue.16
, pp. 2462-2478
-
-
Seth, A.1
Watson, D.K.2
-
55
-
-
0036488589
-
Role of integrins in cell invasion and migration
-
Hood JD, Cheresh DA. Role of integrins in cell invasion and migration. Nat Rev Cancer 2002;2(2):91-100
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.2
, pp. 91-100
-
-
Hood, J.D.1
Cheresh, D.A.2
-
56
-
-
33748358343
-
Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression
-
DOI 10.1186/1471-2407-6-181
-
Larkins TL, Nowell M, Singh S, et al. Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression. BMC Cancer 2006;6:181: published online 10 July 2006, doi:10.1186/1471-2407-6-181 (Pubitemid 44335961)
-
(2006)
BMC Cancer
, vol.6
, pp. 181
-
-
Larkins, T.L.1
Nowell, M.2
Singh, S.3
Sanford, G.L.4
-
57
-
-
0347594125
-
Prognostic value of Rho GTPases and Rho guanine nucleotide dissociation inhibitors in human breast cancers
-
Jiang WG, Watkins G, Lane J, et al. Prognostic value of Rho GTPases and Rho guanine nucleotide dissociation inhibitors in human breast cancers. Clin Cancer Res 2003;9(17):6432-6440
-
(2003)
Clin Cancer Res
, vol.9
, Issue.17
, pp. 6432-6440
-
-
Jiang, W.G.1
Watkins, G.2
Lane, J.3
-
58
-
-
34548052025
-
Biphasic expression of RhoGDI2 in the progression of breast cancer and its negative relation with lymph node metastasis
-
Hu LD, Zou HF, Zhan SX, et al. Biphasic expression of RhoGDI2 in the progression of breast cancer and its negative relation with lymph node metastasis. Oncol Rep 2007;17(6):1383-1389
-
(2007)
Oncol Rep
, vol.17
, Issue.6
, pp. 1383-1389
-
-
Hu, L.D.1
Zou, H.F.2
Zhan, S.X.3
-
59
-
-
65249157082
-
RhoGDI2 expression is associated with tumor growth and malignant progression of gastric cancer
-
Cho HJ, Baek KE, Park SM, et al. RhoGDI2 expression is associated with tumor growth and malignant progression of gastric cancer. Clin Cancer Res 2009;15(8):2612-2619
-
(2009)
Clin Cancer Res
, vol.15
, Issue.8
, pp. 2612-2619
-
-
Cho, H.J.1
Baek, K.E.2
Park, S.M.3
-
60
-
-
0027441685
-
Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and Rac 1
-
Adra CN, Ko J, Leonard D, et al. Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and Rac 1. Genes Chromosomes Cancer 1993;8(4):253-261
-
(1993)
Genes Chromosomes Cancer
, vol.8
, Issue.4
, pp. 253-261
-
-
Adra, C.N.1
Ko, J.2
Leonard, D.3
-
61
-
-
0032579315
-
Differential properties of D4/LyGDI versus RhoGDI: Phosphorylation and rho GTPase selectivity
-
Gorvel JP, Chang TC, Boretto J, et al. Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity. FEBS Lett 1998;422(2):269-273
-
(1998)
FEBS Lett
, vol.422
, Issue.2
, pp. 269-273
-
-
Gorvel, J.P.1
Chang, T.C.2
Boretto, J.3
-
62
-
-
66149117890
-
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases
-
Moissoglu K, McRoberts KS, Meier JA, et al. Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. Cancer Res 2009;69(7):2838-2844
-
(2009)
Cancer Res
, vol.69
, Issue.7
, pp. 2838-2844
-
-
Moissoglu, K.1
McRoberts, K.S.2
Meier, J.A.3
-
63
-
-
65249180152
-
Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function
-
Wu Y, Moissoglu K, Wang H, et al. Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function. Proc Natl Acad Sci 2009;106(14):5807-5812
-
(2009)
Proc Natl Acad Sci
, vol.106
, Issue.14
, pp. 5807-5812
-
-
Wu, Y.1
Moissoglu, K.2
Wang, H.3
-
64
-
-
67651205736
-
ZAK negatively regulates RhoGDIbeta-induced Rac1-mediated hypertrophic growth and cell migration
-
published online 18 June 2009, doi:10.1186/1423-0127-16-56
-
Huang CY, Yang LC, Liu KY, et al. ZAK negatively regulates RhoGDIbeta-induced Rac1-mediated hypertrophic growth and cell migration. J Biomed Sci 2009;16:56: published online 18 June 2009, doi:10.1186/1423-0127-16- 56
-
(2009)
J Biomed Sci
, vol.16
, pp. 56
-
-
Huang, C.Y.1
Yang, L.C.2
Liu, K.Y.3
-
65
-
-
63449109564
-
RhoGDIbeta-induced hypertrophic growth in H9c2 cells is negatively regulated by ZAK
-
published online 22 January 2009, doi:10.1186/1423-0127-16-11
-
Huang CY, Yang LC, Liu KY, et al. RhoGDIbeta-induced hypertrophic growth in H9c2 cells is negatively regulated by ZAK. J Biomed Sci 2009;16:11: published online 22 January 2009, doi:10.1186/1423-0127-16-11
-
(2009)
J Biomed Sci
, vol.16
, pp. 11
-
-
Huang, C.Y.1
Yang, L.C.2
Liu, K.Y.3
-
66
-
-
0034637132
-
Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif
-
Liu TC, Huang CJ, Chu YC, et al. Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. Biochem Biophys Res Commun 2000;274(3):811-816
-
(2000)
Biochem Biophys Res Commun
, vol.274
, Issue.3
, pp. 811-816
-
-
Liu, T.C.1
Huang, C.J.2
Chu, Y.C.3
-
67
-
-
33847674106
-
Rac signaling in tumorigenesis and as target for anticancer drug development
-
Sun D, Xu D, Zhang B. Rac signaling in tumorigenesis and as target for anticancer drug development. Drug Resist Updat 2006;9(6):274-287
-
(2006)
Drug Resist Updat
, vol.9
, Issue.6
, pp. 274-287
-
-
Sun, D.1
Xu, D.2
Zhang, B.3
-
68
-
-
0037147241
-
Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways
-
Groysman M, Hornstein I, Alcover A, et al. Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways. J Biol Chem 2002;277(51):50121-50130
-
(2002)
J Biol Chem
, vol.277
, Issue.51
, pp. 50121-50130
-
-
Groysman, M.1
Hornstein, I.2
Alcover, A.3
-
69
-
-
0027232261
-
A novel role for RhoGDI as an inhibitor of GAP proteins
-
Hancock JF, Hall A. A novel role for RhoGDI as an inhibitor of GAP proteins. EMBO J 1993;12(5):1915-1921
-
(1993)
EMBO J
, vol.12
, Issue.5
, pp. 1915-1921
-
-
Hancock, J.F.1
Hall, A.2
-
70
-
-
41249100873
-
Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor
-
Kweon SM, Cho YJ, Minoo P, et al. Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor. J Biol Chem 2008;283(6):3023-3030
-
(2008)
J Biol Chem
, vol.283
, Issue.6
, pp. 3023-3030
-
-
Kweon, S.M.1
Cho, Y.J.2
Minoo, P.3
-
71
-
-
14644420930
-
Interfacial inhibition of macromolecular interactions: Nature's paradigm for drug discovery
-
Pommier Y, Cherfils J. Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery. Trends Pharmacol Sci 2005;26(3):138-145
-
(2005)
Trends Pharmacol Sci
, vol.26
, Issue.3
, pp. 138-145
-
-
Pommier, Y.1
Cherfils, J.2
-
72
-
-
28844443476
-
Arf, Sec7 and Brefeldin A: A model towards the therapeutic inhibition of guanine nucleotide-exchange factors
-
Zeghouf M, Guibert B, Zeeh JC, et al. Arf, Sec7 and Brefeldin A: a model towards the therapeutic inhibition of guanine nucleotide-exchange factors. Biochem Soc Trans 2005;33(Pt 6):1265-1268
-
(2005)
Biochem Soc Trans
, vol.33
, Issue.PART 6
, pp. 1265-1268
-
-
Zeghouf, M.1
Guibert, B.2
Zeeh, J.C.3
-
73
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
-
DOI 10.1038/35888
-
Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998;391(6669):806-811 (Pubitemid 28099681)
-
(1998)
Nature
, vol.391
, Issue.6669
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
74
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann TS, Lee AC, Akinc A, et al. RNAi-mediated gene silencing in non-human primates. Nature 2006;441(7089):111-114
-
(2006)
Nature
, vol.441
, Issue.7089
, pp. 111-114
-
-
Zimmermann, T.S.1
Lee, A.C.2
Akinc, A.3
-
75
-
-
33644854484
-
Rho GTPases promising cellular targets for novel anticancer drugs
-
Fritz G, Kaina B. Rho GTPases: promising cellular targets for novel anticancer drugs. Curr Cancer Drug Targets 2006;6(1):1-14
-
(2006)
Curr Cancer Drug Targets
, vol.6
, Issue.1
, pp. 1-14
-
-
Fritz, G.1
Kaina, B.2
-
76
-
-
12344264745
-
Targeting Ras and Rho GTPases as opportunities for cancer therapeutics
-
Walker K, Olson MF. Targeting Ras and Rho GTPases as opportunities for cancer therapeutics. Curr Opin Genet Dev 2005;15(1):62-68
-
(2005)
Curr Opin Genet Dev
, vol.15
, Issue.1
, pp. 62-68
-
-
Walker, K.1
Olson, M.F.2
-
77
-
-
2442664118
-
Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
-
Gao Y, Dickerson JB, Guo F, et al. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci 2004;101(20):7618-7623
-
(2004)
Proc Natl Acad Sci
, vol.101
, Issue.20
, pp. 7618-7623
-
-
Gao, Y.1
Dickerson, J.B.2
Guo, F.3
-
78
-
-
10144252434
-
Targeted disruption of guanosine diphosphate-dissociation inhibitor for Rho-related proteins, GDID4: Normal hematopoietic differentiation but subtle defect in superoxide production by macrophages derived from in vitro embryonal stem cell differentiation
-
Guillemot JC, Kruskal BA, Adra CN, et al. Targeted disruption of guanosine diphosphate-dissociation inhibitor for Rho-related proteins, GDID4: normal hematopoietic differentiation but subtle defect in superoxide production by macrophages derived from in vitro embryonal stem cell differentiation. Blood 1996;88(7):2722-2731
-
(1996)
Blood
, vol.88
, Issue.7
, pp. 2722-2731
-
-
Guillemot, J.C.1
Kruskal, B.A.2
Adra, C.N.3
-
79
-
-
0030869004
-
Immune responses in mice deficient in Ly-GDI, a lymphoid-specific regulator of Rho GTPases
-
Yin L, Schwartzberg P, Scharton-Kersten TM, et al. Immune responses in mice deficient in Ly-GDI, a lymphoid-specific regulator of Rho GTPases. Mol Immunol 1997;34(6):481-491
-
(1997)
Mol Immunol
, vol.34
, Issue.6
, pp. 481-491
-
-
Yin, L.1
Schwartzberg, P.2
Scharton-Kersten, T.M.3
|