Healthcare costs of GERD and acid-related conditions in pediatric patients, with comparison between histamine-2 receptor antagonists and proton pump inhibitors

Current Medical Research and Opinion

Volumn 25, Issue 11, 2009, Pages 2703-2709

  Kothari, S ^a   Nelson, S P ^b   Wu, Eric Q ^c   Beaulieu, N ^c   McHale, J M ^c   Dabbous, O H ^d  

^a ASTELLAS PHARMA GLOBAL DEVELOPMENT   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c ANALYSIS GROUP   (United States)

^d TAKEDA PHARMACEUTICALS   (United States)

Author keywords

Acid related conditions; Claims database; Gastroesophageal reflux disease; Healthcare costs; Histamine 2 receptor antagonists; Proton pump inhibitors

Indexed keywords

BETHANECHOL; CIMETIDINE; ESOMEPRAZOLE; FAMOTIDINE; LANSOPRAZOLE; METOCLOPRAMIDE; NIZATIDINE; OMEPRAZOLE; PANTOPRAZOLE; RABEPRAZOLE; RANITIDINE;

ACID RELATED CONDITION; ARTICLE; CHILD; CONTROLLED STUDY; COST OF ILLNESS; DRUG COST; FEMALE; GASTROESOPHAGEAL REFLUX; HEALTH CARE UTILIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MONEY; STOMACH FUNCTION DISORDER;

ADOLESCENT; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; COMORBIDITY; FEMALE; GASTRIC ACID; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL DISEASES; HEALTH CARE COSTS; HISTAMINE H2 ANTAGONISTS; HUMANS; MALE; PROTON PUMP INHIBITORS;

EID: 72549111144     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007990903307755     Document Type: Article

References (25)

1. Rudolph CD, Mazur LJ, Liptak GS, et al. Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: Recommendations of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr 2001;32:S1-31
2. Dodge J. Gastro-oesophageal reflux in infants. Acta Paediatr 1999;88:359-360
3. Nelson SP, Chen EH, Syniar GM, et al. Prevalence of symptoms of gastroesophageal reflux during childhood - a pediatric practice-based survey. Arch Pediatr Adolesc Med 2000;154:150-154 (Pubitemid 30075195)
4. Nelson SP, Chen EH, Syniar GM, et al. Prevalence of symptoms of gastroesophageal reflux during infancy - a pediatric practice-based survey. Arch Pediatr Adolesc Med 1997;151:569-572
5. Dahms BB. Reflux esophagitis: Sequelae and differential diagnosis in infants and children including eosinophilic esophagitis. Pediatr Dev Pathol 2004;7:5-16
6. Shepherd RW, Wren J, Evans S, et al. Gastroesophageal reflux in children. Clinical profile, course and outcome with active therapy in 126 cases. Clin Pediatr 1987;26:55-60
7. Treem WR, Davis PM, Hyams JS. Gastroesophageal reflux in the older-child - presentation, response to treatment and long-term follow-up. Clin Pediatr 1991;30:435-440
8. Tolia V, Essenmacher L, Ager J. Gastroesophageal reflux disease (GER) questionnaire to assess quality of life (QOL) in patients and parents. Am J Gastroenterol 2005;100:S381-2
9. Chiba N, DeGara CJ, Wilkinson JM, et al. Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: a meta-analysis. Gastroenterology 1997;112:1798-1810 (Pubitemid 27240763)
10. DeGiacomo C, Bawa P, Franceschi M, et al. Omeprazole for severe reflux esophagitis in children. J Pediatr Gastroenterol Nutr 1997;24:528-532 (Pubitemid 27216868)
11. Kato S, Ebina K, Fujii K, et al. Effect of omeprazole in the treatment of refractory acid-related diseases in childhood: endoscopic healing and twenty-four-hour intragastric acidity. J Pediatr 1996;128:415-421 (Pubitemid 26087547)
12. Hassall E, Israel D, Shepherd R, et al. Omeprazole for treatment of chronic erosive esophagitis in children: a multicenter study of efficacy, safety, tolerability and dose requirements. J Pediatr 2000;137:800-807
13. Franco MT, Salvia G, Terrin G, et al. Lansoprazole in the treatment of gastrooesophageal reflux disease in childhood. Dig Liver Dis 2000;32:660-666
14. Sabesin SM, Berlin RG, Humphries TJ, et al. Famotidine relieves symptoms of gastroesophageal reflux disease and heals erosions and ulcerations - results of a multicenter, placebo-controlled, dose-ranging study. Arch Intern Med 1991;151:2394-2400
15. Sandler RS, Everhart JE, Donowitz M, et al. The burden of selected digestive diseases in the United States. Gastroenterology 2002;122:1500-1511 (Pubitemid 34465190)
16. Association AG. The Burden of Gastrointestinal Disease. Bethesda, MD: American Gastroenterology Association, 2001
17. Gibbons TE, Stockwell J, Kreh RP, et al. Population based epidemiological survey of gastroesophageal reflux disease in hospitalized US children. Gastroenterology 2001;120:A419-A
18. Gold BD. Outcomes of pediatric gastroesophageal reflux disease: in the first year of life, in childhood, and in adults... Oh, and should we really leave Helicobacter pylori alone? J Pediatr Gastroenterol Nutr 2003;37:S33-9
19. Gilmer TP, Roze S, Valentine WJ, et al. Cost-effectiveness of diabetes case management for low-income populations. Health Serv Res 2007;42:1943-1959 (Pubitemid 47397181)
20. Brook RA, Wahlqvist P, Kleinman NL, et al. Cost of gastro-oesophageal reflux disease to the employer: a perspective from the United States. Aliment Pharmacol Ther 2007;26:889-898 (Pubitemid 47346705)
21. Chan J, Levin TR. Long-term drug treatment of GERD - economic issues for formulary decision makers. Dis Manag Health Outcomes 2004;12:399-407 (Pubitemid 40023590)
22. DeVault KR, Castell DO. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol 1999;94:1434-1442 (Pubitemid 29260426)
23. Ofman JJ, Dorn GH, Fennerty MB, et al. The clinical and economic impact of competing management strategies for gastro-oesophageal reflex disease. Aliment Pharmacol Ther 2002;16:261-273 (Pubitemid 34146367)
24. Goeree R, O'Brien BJ, Blackhouse G, et al. Cost-effectiveness and cost-utility of long-term management strategies for heartburn. Value Health 2002;5:312-328 (Pubitemid 36998744)
25. Sonnenberg A, Inadomi JM, Becker LA. Economic analysis of step-wise treatment of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 1999;13:1003-1013 (Pubitemid 29374099)