The effect of spironolactone on sweat and urinary sodium excretion during exercise in humans

Clinical Physiology and Functional Imaging

Volumn 30, Issue 1, 2010, Pages 13-16

  Lee, Nanette V L ^a   Miller, Paul W ^a   Buono, Michael J ^a,b  

^a School of Exercise and Nutritional Sciences   (United States)

^b SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

Aldosterone; Spironolactone; Sweat sodium concentration; Urinary sodium

Indexed keywords

MINERALOCORTICOID RECEPTOR; PLACEBO; SPIRONOLACTONE;

ADULT; ARTICLE; CLINICAL TRIAL; EXERCISE; FLAME PHOTOMETRY; HEART RATE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PRIORITY JOURNAL; SODIUM EXCRETION; SODIUM URINE LEVEL; SWEATING;

ADULT; ALDOSTERONE ANTAGONISTS; EXERCISE; FEMALE; HEART RATE; HUMANS; HUMIDITY; MALE; PLACEBOS; SODIUM; SPIRONOLACTONE; SWEAT; YOUNG ADULT;

EID: 72549106083     PISSN: 14750961     EISSN: 1475097X     Source Type: Journal    
DOI: 10.1111/j.1475-097X.2009.00898.x     Document Type: Article

References (12)

1. Bolydreff B, Wehling M. Non-genomic actions of aldosterone: mechanisms and consequences in kidney cells. Nephrol Dial Transplant 2003, 18:1693-1695.
2. Buono MJ, Ball KD, Kolkhorst FW. Sodium ion concentration vs. sweat rate relationship in humans. J Appl Physiol 2007, 103:990-994.
3. Cage GW, Dobson RL. Sodium secretion and reabsorption in the human eccrine sweat gland. J Clin Invest 1965, 44:1270-1276.
4. Funder JW, Pearce PT, Smith R, Smith AI. Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science 1988, 242:583-585.
5. Hegarty JM, Harvey BJ. Aldosterone increases intracellular calcium in cultured human sweat gland epithelial cells by non-genomic mechanism of action. J Physiol (London) 1998, 511.
6. Hegarty JM, Harvey BJ. Aldosterone accelerates a Na+/H+ exchange dependent pH recovery after acid loading in cultured human eccrine sweat gland epithelial cells. J Physiol (London) 1999, 517:20P.
7. Kenouch S, Lombes M, Delahaye F, Eugene E, Bonvalet JP, Farman N. Human skin as target for aldosterone: coexpression of mineralocorticoid receptors and 11β-hydroxysteroid dehydrogenase. J Clin Endocrinol Metab 1994, 79:1334-1341.
8. Ladell WSS, Shephard RJ. Aldosterone inhibition and acclimatization to heat. J Physiol 1961, 160:19P-20P.
9. Rogerson FM, Brennan FE, Fuller PJ. Mineralocorticoid receptor binding, structure, and function. Mol Cell Endocrinol 2004, 217:203-212.
10. Shuster S. Adrenal control of eccrine sweat secretion. J R Soc Med 1962, 55:719-720.
11. Yoshida T, Shin-ya H, Nakai S, Yorimoto A, Morimoto T, Suyama T, Sakurai M. Genomic and non-genomic effects of aldosterone on the individual variation of the sweat Na+ concentration during exercise in trained athletes. Eur J Appl Physiol 2006, 98:466-471.
12. Zennaro M, Farman N, Bonvalet JP, Lombes M. Tissue-specific expression of α and β messenger ribonucleic acid isoforms of the human mineralocorticoid receptor in normal and pathological states. J Clin Endocrinol Metab 1997, 82:1345-1352.