P53-mediated G1/S checkpoint dysfunction in lymphocytes from Alzheimer's disease patients

Neuroscience Letters

Volumn 468, Issue 3, 2010, Pages 320-325

  Zhou, Xiaoying ^a,b   Jia, Jianping ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b Key Neurodegenerative Laboratory of Ministry of Education   (China)

Author keywords

Alzheimer's disease; Conformation; G1 S checkpoint; Lymphocytes; P53

Indexed keywords

BIOLOGICAL MARKER; PROTEIN P53;

AGED; ALZHEIMER DISEASE; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; IMMUNOREACTIVITY; LYMPHOCYTE ACTIVATION; MALE; NERVE CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION;

AGED; ALZHEIMER DISEASE; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; G1 PHASE; HUMANS; LYMPHOCYTES; MALE; PROTEIN CONFORMATION; S PHASE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 72549104579     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.11.024     Document Type: Article

References (21)

1. Britschgi M., and Wyss-Coray T. Blood protein signature for the early diagnosis of Alzheimer disease. Arch. Neurol. 66 (2009) 161-165
2. 1 arrest following transient inhibition of the mitotic spindle. J. Biol. Chem. 276 (2001) 19205-19213
3. de las Cuevas N., Urcelay E., Hermida O.G., Saiz-Diaz R.A., Bermejo F., Ayuso M.S., and Martin-Requero A. Ca2+/calmodulin-dependent modulation of cell cycle elements pRb and p27kip1 involved in the enhanced proliferation of lymphoblasts from patients with Alzheimer dementia. Neurobiol. Dis. 13 (2003) 254-263
4. Facchetti M., Uberti D., Memo M., and Missale C. Nerve growth factor restores p53 function in pituitary tumor cell lines via trkA-mediated activation of phosphatidylinositol 3-Kinase. Mol. Endocrinol. 18 (2004) 162-172
5. Golubnitschaja O. Cell cycle checkpoints: the role and evaluation for early diagnosis of senescence, cardiovascular, cancer, and neurodegenerative diseases. Amino Acids 32 (2007) 359-371
6. Hernández-Ortega K., Ferrera P., and Arias C. Sequential expression of cell-cycle regulators and Alzheimer's disease-related proteins in entorhinal cortex after hippocampal excitotoxic damage. J. Neurosci. Res. 85 (2007) 1744-1751
7. Inoue T., Stuart J., Leno R., and Maki C.G. Nuclear import and export signals in control of the p53-related protein p73. J. Biol. Chem. 277 (2002) 15053-15060
8. Jeffers J.R., Parganas E., Lee Y., Yang C., Wang J., Brennan J., MacLean K.H., Han J., Chittenden T., Ihle J.N., McKinnon P.J., Cleveland J.L., and Zambetti G.P. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4 (2003) 321-328
9. Li Y., Raffo A.J., Drew L., Mao Y., Tran A., Petrylak D.P., and Fine R.L. Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143. Cancer Res. 63 (2003) 1527-1533
10. Lim A.C., and Qi R.Z. Cyclin-dependent kinases in neural development and degeneration. J. Alzheimers Dis. 5 (2003) 329-335
11. Mecocci P., Polidori M.C., Ingegni T., Cherubini A., Chionne F., Cecchetti R., and Senin U. Oxidative damage to DNA in lymphocytes from AD patients. Neurology 51 (1998) 1014-1017
12. Meplan C., Richard M.J., and Hainaut P. Redox signalling and transition metals in the control of the p53 pathway. Biochem. Pharmacol. 59 (2000) 25-33
13. Müller P., Ceskova P., and Vojtesek B. Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: IMPLICATIONS FOR CANCER THERAPY. J. Biol. Chem. 280 (2005) 6682-6691
14. Nagy Z., Combrinck M., Budge M., and McShane R. Cell cycle kinesis in lymphocytes in the diagnosis of Alzheimer's disease. Neurosci. Lett. 317 (2002) 81-84
15. Nemoto T., Kamei S., Seyama Y., and Kubota S. p53 independent G(1) arrest induced by DL-alpha-difluoromethylornithine. Biochem. Biophys. Res. Commun. 280 (2001) 848-854
16. Shackelford R.E., Kaufmann W.K., and Paules R.S. Oxidative stress and cell cycle checkpoint function. Free Radic. Biol. Med. 28 (2000) 1387-1404
17. Tripathi V., Ali A., Bhat R., and Pati U. CHIP chaperones wild type p53 tumor suppressor protein. J. Biol. Chem. 282 (2007) 28441-28454
18. Uberti D., Carsana T., Bernardi E., Rodella L., Grigolato P., Lanni C., Racchi M., Govoni S., and Memo M. Selective impairment of p53-mediated cell death in fibroblasts from sporadic Alzheimer's disease patients. J. Cell Sci. 115 (2002) 3131-3138
19. Uberti D., Lanni C., and Racchi M. Conformationally altered p53: a putative peripheral marker for Alzheimers disease. Neurodegenerative Dis. 5 (2008) 209-211
20. Urcelay E., Ibarreta D., Parrilla R., Ayuso M.S., and Martin-Requero A. Enhanced proliferation of lymphoblasts from patients with Alzheimer dementia associated with calmodulin-dependent activation of the na+/H+ exchanger. Neurobiol. Dis. 8 (2001) 289-298
21. Yang Y., Mufson E.J., and Herrup K. Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease. J. Neurosci. 23 (2003) 2557-2563