Retention of gene products in syncytial spermatids promotes non-Mendelian inheritance as revealed by the t complex responder

Genes and Development

Volumn 23, Issue 23, 2009, Pages 2705-2710

  Véron, Nathalie ^a,b   Bauer, Hermann ^a   Weiße, Andrea Y ^b,d   Lüder, Gerhild ^a   Werber, Martin ^a,c   Herrmann, Bernhard G ^a,c  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Motility; Mouse; Non Mendelian inheritance; Spermatogenesis; t haplotype; Transmission ratio distortion

Indexed keywords

GENE PRODUCT; PHOSPHOTRANSFERASE; RIBONUCLEOPROTEIN; SPERM MOTILITY KINASE 1; T COMPLEX RESPONDER; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EPIDIDYMIS; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC CODE; GENOTYPE; GERM CELL; HAPLOIDY; HAPLOTYPE; INHERITANCE; MALE; MAMMAL; MEIOSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE MYC; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPERM; SPERMATID; SPERMATOZOON MOTILITY; SYNCYTIUM; TESTIS; TRANSGENE; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INHERITANCE PATTERNS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PHENOTYPE; PROTEIN KINASES; SPERMATIDS;

MAMMALIA; MUS MUSCULUS;

EID: 72549094287     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.553009     Document Type: Article

References (27)

1. Bauer H, Willert J, Koschorz B, Herrmann BG. 2005. The t complex-encoded GTPase-activating protein tagap1 acts as a transmission ratio distorter in mice. Nat Genet 37: 969-973. (Pubitemid 43086154)
2. Bauer H, Veron N, Willert J, Herrmann BG. 2007. The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse. Genes & Dev 21: 143-147. (Pubitemid 46155808)
3. Braun RE. 1998. Post-transcriptional control of gene expression during spermatogenesis. Semin Cell Dev Biol 9: 483-489. (Pubitemid 128350676)
4. Braun RE, Behringer RR, Peschon JJ, Brinster RL, Palmiter RD. 1989. Genetically haploid spermatids are phenotypically diploid. Nature 337: 373-376.
5. Brent AE, Schweitzer R, Tabin CJ. 2003. A somitic compartment of tendon progenitors. Cell 113: 235-248.
6. Chesley P, Dunn LC. 1936. The inheritance of taillessness (anury) in the house mouse. Genetics 21: 525-536.
7. Curtsinger J, Ito R, Hiraizumi Y, Curtsinger JW. 1983. A two-generation study of human sex-ratio variation. Am J Hum Genet 35: 951-961.
8. Eddy EM, Toshimori K, O'Brien DA. 2003. Fibrous sheath of mammalian spermatozoa. Microsc Res Tech 61: 103-115.
9. Ewens WJ, Grant G. 2005. Statistical methods in bioinformatics. Springer, New York.
10. Fujita A, Nakamura K, Kato T, Watanabe N, Ishizaki T, Kimura K, Mizoguchi A, Narumiya S. 2000. Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. J Cell Sci 113: 103-112. (Pubitemid 30066337)
11. Gardiner CW. 2004. Handbook of stochastic methods: For physics, chemistry and the natural sciences. Springer, New York.
12. Gummere G, McCormick P, Bennett D. 1986. The influence of genetic background and the homologous chromosome 17 on t-haplotype transmission ratio distortion in mice. Genetics 114: 235-245. (Pubitemid 16022494)
13. Hecht NB. 1998. Molecular mechanisms of male germ cell differentiation. Bioessays 20: 555-561. (Pubitemid 28362301)
14. Herrmann B, Koschorz B, Wertz K, McLaughlin K, Kispert A. 1999. A protein kinase encoded by the t complex responder gene causes nonmendelian inheritance. Nature 402: 141-146.
15. Hesketh T, Xing ZW. 2006. Abnormal sex ratios in human populations: Causes and consequences. Proc Natl Acad Sci 103: 13271-13275. (Pubitemid 44380098)
16. Hurst GD, Werren JH. 2001. The role of selfish genetic elements in eukaryotic evolution. Nat Rev Genet 2: 597-606.
17. James WH. 2009. The variations of human sex ratio at birth during and after wars, and their potential explanations. J Theor Biol 257: 116-123.
18. Katz D, Erickson R, Nathanson M. 1979. Beat frequency is bimodally distributed in spermatozoa from t/t12 mice. J Exp Zool 210: 529-535.
19. Kierszenbaum AL. 2002. Intramanchette transport (imt): Managing the making of the spermatid head, centrosome, and tail. Mol Reprod Dev 63: 1-4.
20. Lyon MF. 1984. Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell 37: 621-628.
21. Lyon MF. 2003. Transmission ratio distortion in mice. Annu Rev Genet 37: 393-408.
22. Martin-DeLeon PA, Zhang H, Morales CR, Zhao Y, Rulon M, Barnoski BL, Chen H, Galileo DS. 2005. Spam1-associated transmission ratio distortion in mice: Elucidating the mechanism. Reprod Biol Endocrinol 3: 32. doi: 10.1186/1477-7827-3-32. (Pubitemid 41522402)
23. Olds-Clarke P, Johnson LR. 1993. T haplotypes in the mouse compromise sperm flagellar function. Dev Biol 155: 14-25. (Pubitemid 23112041)
24. Russell L, Ettlin R, Hikim A, Clegg E. 1990. Histological and histopathological evaluation of the testis. Cache River Press, Saint Louis, MO.
25. Schimenti J. 2000. Segregation distortion of mouse t haplotypes the molecular basis emerges. Trends Genet 16: 240-243. (Pubitemid 30332137)
26. Van Heyningen V, Yeyati PL. 2004. Mechanisms of non-Mendelian inheritance in genetic disease. Hum Mol Genet 13: R225-R233. doi: 10.1093/hmg/ddh254. (Pubitemid 39359907)
27. Ventela S, Toppari J, Parvinen M. 2003. Intercellular organelle traffic through cytoplasmic bridges in early spermatids of the rat: Mechanisms of haploid gene product sharing. Mol Biol Cell 14: 2768-2780. (Pubitemid 36871520)