The response of Pseudomonas aeruginosa PAO1 efflux pump-defective mutants to N-Octanoyl-L-Homoserine lactone

Microbes and Environments

Volumn 24, Issue 4, 2009, Pages 338-342

  Yawata, Yutaka ^a   Maseda, Hideaki ^a,b   Okabe, Satoshi ^c   Ito, Akinobu ^c   Sawada, Isao ^a,d   Kurashima, Hiroaki ^a   Uchiyama, Hiroo ^a   Nomura, Nobuhiko ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

^d KOBE UNIVERSITY   (Japan)

Author keywords

Acyl homoserine lactone; Cell cell communication; Pseudomonas aeruginosa

Indexed keywords

BACTERIA (MICROORGANISMS); BURKHOLDERIA CENOCEPACIA; PSEUDOMONAS AERUGINOSA;

EID: 72549085275     PISSN: 13426311     EISSN: 13426311     Source Type: Journal    
DOI: 10.1264/jsme2.ME09130     Document Type: Article

References (29)

1. Brint, J.M., and D.E. Ohman. 1995. Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the auto-inducer-responsive LuxR-LuxI family. J. Bacteriol. 177:7155-7163.
2. Cox, C.D. 1986. Role of pyocyanin in the acquisition of iron from transferrin. Infect. Immun. 52:263-270.
3. Erickson, D.L., R. Endersby, A. Kirkham, K. Stuber, D.D. Vollman, H.R. Rabin, I. Mitchell, and D.G. Storey. 2002. Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis. Infect. Immun. 70:1783-1790.
4. Evans, K., L. Passador, R. Srikumar, E. Tsang, J. Nezezon, and K. Poole. 1998. Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa. J. Bacteriol. 180:5443-5447.
5. Gambello, M.J., S. Kaye, and B.H. Iglewski. 1993. LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr) and an enhancer of exotoxin A expression. Infect. Immun. 61:1180-1184.
6. Girard, G., and G.V. Bloemberg. 2008. Central role of quorum sensing in regulating the production of pathogenicity factors in Pseudomonas aeruginosa. Future Microbiol. 3:97-106.
7. Govan, J.R., and V. Deretic. 1996. Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol. Rev. 60:539-574.
8. Heurlier, K., V. Dénervaud, and D. Hass. 2006. Impact of quorum sensing on fitness of Pseudomonas aeruginosa. Int. J. Med. Microbiol. 296:93-102.
9. Latifi, A., M.K. Winson, M. Foglino, B.W. Bycroft, G.S. Stewart, A. Lazdunski, and P. Williams. 1995. Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1. Mol. Microbiol. 17:333-343.
10. Lee, J.H., Y. Lequette, and E.P. Greenberg. 2006. Activity of purified QscR, a Pseudomonas aeruginosa orphan quorum-sensing transcription factor. Mol. Microbiol. 59:602-609.
11. Li, X.Z., H. Nikaido, and K. Poole. 1995. Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39:1948-1953.
12. Mahajan-Miklos, S., M.W. Tan, L.G. Rahme, and F.M. Ausubel. 1999. Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. Cell 96:47-56.
13. Maseda, H., H. Yoneyama, and T. Nakae. 2000. Assignment of the substrate-selective subunits of the MexEF-OprN multidrug efflux pump of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 44:658-664.
14. Maseda, H., K. Saito, A. Nakajima, and T. Nakae. 2000. Variation of the mexT gene, a regulator of the MexEF-oprN efflux pump expression in wild-type strains of Pseudomonas aeruginosa. FEMS Microbiol. Lett. 192:107-112.
15. Maseda, H., I. Sawada, K. Saito, H. Uchiyama, T. Nakae, and N. Nomura. 2004. Enhancement of the mexAB-oprM efflux pump expression by a quorum-sensing autoinducer and its cancellation by a regulator, MexT, of the mexEF-oprN efflux pump operon in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 48:1320-1328.
16. Mavrodi, D.V., R.F. Bonsall, S.M. Delaney, M.J. Soule, G. Phillips, and L.S. Thomashow. 2001. Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1. J. Bacteriol. 183:6454-6465.
17. Ochsner, U.A., and J. Reiser. 1995. Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 92:6424-6428.
18. Pearson, J.P., L. Passador, B.H. Iglewski, and E.P. Greenberg. 1995. A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 92:1490-1494.
19. Pearson, J.P., E.C. Pesci, and B.H. Iglewski. 1997. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes. J. Bacteriol. 179:5756-5767.
20. Pearson, J.P., C. Van Delden, and B.H. Iglewski. 1999. Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals. J. Bacteriol. 181:1203-1210.
21. Pesci, E.C., J.P. Pearson, P.C. Seed, and B.H. Iglewski. 1997. Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa. J. Bacteriol. 179:3127-3132.
22. Poole, K. 2001. Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms. J. Mol. Microbiol. Biotechnol. 3:255-264.
23. Riedel, K., M. Hentzer, O. Geisenberger, et al. 2001. N-Acyl-homoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms. Microbiology 147:3249-3262.
24. Sambrook, J., and D.W. Russell. 2001. Molecular Cloning: A Laboratory Manual, 3rd ed. Cold Spring Harbor Laboratory Press, New York, USA.
25. Schuster, M., C.P. Lostroh, T. Ogi, and E.P. Greenberg. 2003. Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis. J. Bacteriol. 185:2066-2079.
26. Singh, P.K., A.L. Schaefer, M.R. Parsek, T.O. Moninger, M.J. Welsh, and E.P. Greenberg. 2000. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 407:762-764.
27. Taccetti, G., S. Campana, A.S. Neri, V. Boni, and F. Festini. 2008. Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis. J. Chemother. 20:166-169.
28. Taga, M., and B.L. Bassler. 2003. Chemical communication among bacteria. Proc. Natl. Acad. Sci. USA 100:14549-14554.
29. Willcox, M.D., H. Zhu, T.C. Conibear, E.B. Hume, M. Givskov, S. Kjelleberg, and S.A. Rice. 2008. Role of quorum sensing by Pseudomonas aeruginosa in microbial keratitis and cystic fibrosis. Microbiology 154:2184-2194.