Cutaneous lesions as initial signs of interferon α-induced sarcoidosis: Report of three new cases and review of the literature

Dermatologic Therapy

Volumn 22, Issue SUPPL. 1, 2009, Pages

  Fantini, Fabrizio ^a,b   Padalino, Claudia ^b   Gualdi, Giulio ^b   Monari, Paola ^b   Giannetti, Alberto ^b  

^a Clinica Dermatologica   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Interferon alpha; Sarcoidosis; Side effect

Indexed keywords

ALPHA INTERFERON; RIBAVIRIN; STEROID;

ADULT; CASE REPORT; CELL INFILTRATION; DRUG ERUPTION; DRUG WITHDRAWAL; ERYTHEMA; FEMALE; GIANT CELL; HEPATITIS C; HUMAN; HUMAN TISSUE; MULTIPLE CYCLE TREATMENT; REVIEW; SARCOIDOSIS; SKIN BIOPSY; SKIN DISEASE; SKIN INFLAMMATION; SKIN SARCOIDOSIS; SUBCUTANEOUS NODULE;

ANTIVIRAL AGENTS; DRUG ERUPTIONS; FEMALE; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; MIDDLE AGED; SARCOIDOSIS;

EID: 72449192218     PISSN: 13960296     EISSN: 15298019     Source Type: Journal    
DOI: 10.1111/j.1529-8019.2009.01263.x     Document Type: Review

References (64)

1. Abdi EA, Nguyen G-K, Ludwig RN, Dickout WJ. Pulmonary sarcoidosis following interferon therapy for advanced renal cell carcinoma. Cancer 1987 : 59 : 896 900.
2. Liozon E, Cransac M, Remenieras L, Catry-Thomas I, Vovor A, Bordessoule D. La sarcoidose: une nouvelle complication de traitement par l'interféron alpha. Rev Med Interne 1993 : 14 : 1160.
3. Blum L, Serfaty L, Wattiaux MJ, Picard O, Cabane J, Imbert JC. Nodules hypodermiques sarcoidosiques au cours d'une hépatite virale C traitée par interféron alpha 2b. Rev Med Interne 1993 : 14 : 1161.
4. Ohhata I, Ochi T, Kurebayashi S, Masutani H, Kikui M A case of subcutaneous sarcoid nodules induced by interferon-alpha Nihon Kyobu Shikkan Gakkai Zasshi 1994 : 32 : 996 1000.
5. Bobbio-Pallavicini E, Valsecchi C, Tacconi F, Moroni M, Porta C. Sarcoidosis following beta-interferon therapy for multiple myeloma. Sarcoidosis 1995 : 12 : 140 142.
6. Nakajima M, Kubota Y, Miyashita N, Niki Y, Matsushima T, Manabe T. Recurrence of sarcoidosis following interferon alpha therapy for chronic hepatitis C. Intern Med 1996 : 35 : 376 379.
7. Teragawa H, Hondo T, Takahashi K, et al. Sarcoidosis after interferon therapy for chronic active hepatitis C. Intern Med 1996 : 35 : 19 23.
8. Otte HG, Hartig C, Stadler R. Sarkoidose bei interferon-alpha Therapie. Hautarzt 1997 : 48 : 482 487.
9. Hoffmann RM, Jung MC, Motz R, et al. Sarcoidosis associated with interferon-alpha therapy for chronic hepatitis C. J Hepatol 1998 : 28 : 1058 1063.
10. Kikawada M, Ichinose Y, Kunisawa A, et al. Sarcoidosis induced by interferon therapy for chronic myelogenous leukaemia. Respirology 1998 : 3 : 41 44.
11. Mehta CL, Tyler RJ, Cripps DJ. Granulomatous dermatitis with focal sarcoidal features associated with recombinant interferon beta-1b injections. J Am Acad Dermatol 1998 : 39 : 1024 1028.
12. Yavorkovsky LL, Carrum G, Bruce S, McCarthy PL Jr. Cutaneous sarcoidosis in a patient with Philadelphia-positive chronic myelogenous leukemia treated with interferon-alpha. Am J Hematol 1998 : 58 : 80 81.
13. Eberlein-König B, Hein R, Abeck D, Engst R, Ring J. Cutaneous sarcoid foreign body granulomas developing in sites of previous skin injury after systemic interferon-alpha treatment for chronic hepatitis C. Br J Dermatol 1999 : 140 : 370 372.
14. Pietropaoli A, Modrak J, Utell M. Interferon-alpha therapy associated with the development of sarcoidosis. Chest 1999 : 116 : 569 572.
15. Cacoub P, Sbai A, Frances C, Genesti C, Hausfater P, Piette JC Systemic sarcoidosis during interferon-alpha therapy for chronic hepatitis C virus infection Gastroenterol Clin Biol 2000 : 24 : 364 366.
16. Savoye G, Goria O, Herve S, et al. Probable cutaneous sarcoidosis associated with combined ribavirin and interferon-alpha therapy for chronic hepatitis C Gastroenterol Clin Biol 2000 : 24 : 679.
17. Vander Els NJ, Gerdes H. Sarcoidosis and IFN-alpha treatment. Chest 2000 : 117 : 294.
18. Pohl J, Stremmel W, Kallinowski B Pulmonal sarcoidosis: a rare side effect of interferon-alpha treatment for chronic hepatitis C infection Z Gastroenterol 2000 : 38 : 951 955.
19. Frankova H, Gaja A, Hejlova N. Pulmonary sarcoidosis in a patient with essential thrombocythemia treated with interferon alpha: a short case report. Med Sci Monit 2000 : 6 : 380 382.
20. Fiorani C, Sacchi S, Bonacorsi G, Cosenza M. Systemic sarcoidosis associated with interferon-alpha treatment for chronic myelogenous leukemia. Haematologica 2000 : 85 : 1006 1007.
21. Vallina E, Garcia Diez A, Gallego M, Villaverde P, Rippe ML, Arribas JM A case of pulmonary sarcoidosis induced by interferon alfa treatment in a female patient with hepatitis C An Med Interna 2000 : 17 : 538 539.
22. Neglia V, Sookoian S, Herrera M, et al. Development of cutaneous sarcoidosis in a patient with chronic hepatitis C treated with interferon alpha 2b. J Cutan Med Surg 2001 : 5 : 406 408.
23. Miwa H, Furuya T, Tanaka S, Mizuno Y. Neurosarcoidosis associated with interferon therapy. Eur Neurol 2001 : 45 : 288 289.
24. Krehmeier H, Egberts EH Sarcoidosis after interferon-alpha treatment in hepatitis C Dtsch Med Wochenschr 2001 : 126 : 460.
25. Ravenel JG, McAdams HP, Plankeel JF, Butnor KJ, Sporn TA. Sarcoidosis induced by interferon therapy. AJR Am J Roentgenol 2001 : 177 : 199 201.
26. Husa P, Klusakova J, Jancikova J, Husova L, Horalek F. Sarcoidosis associated with interferon-alpha therapy for chronic hepatitis B. Eur J Intern Med 2002 : 13 : 129 131.
27. Cogrel O, Doutre MS, Marliere V, Beylot-Barry M, Couzigou P, Beylot C. Cutaneous sarcoidosis during interferon alfa and ribavirin treatment of hepatitis C virus infection: two cases. Br J Dermatol 2002 : 146 : 320 324.
28. Wendling J, Descamps V, Grossin M, et al. Sarcoidosis during combined interferon alfa and ribavirin therapy in 2 patients with chronic hepatitis C. Arch Dermatol 2002 : 138 : 546 547.
29. Perez-Alvarez R, Perez-Lopez R, Lombrana JL, Rodriguez M, Rodrigo L. Sarcoidosis in two patients with chronic hepatitis C treated with interferon, ribavirin and amantadine. J Viral Hepat 2002 : 9 : 75 79.
30. Nawras A, Alsolaiman MM, Mehboob S, Bartholomew C, Maliakkal B. Systemic sarcoidosis presenting as a granulomatous tattoo reaction secondary to interferon-alpha treatment for chronic hepatitis C and review of the literature. Dig Dis Sci 2002 : 47 : 1627 1631.
31. Noguchi K, Enjoji M, Nakamuta M, Sugimoto R, Kotoh K, Nawata H. Various sarcoid lesions in a patient induced by interferon therapy for chronic hepatitis C. J Clin Gastroenterol 2002 : 35 : 282 284.
32. Gitlin N. Manifestation of sarcoidosis during interferon and ribavirin therapy for chronic hepatitis C: a report of two cases. Eur J Gastroenterol Hepatol 2002 : 14 : 883 835.
33. Yamada S, Mine S, Fujisaki T, Ohnari N, Eto S, Tanaka Y. Hepatic sarcoidosis associated with chronic hepatitis C. J Gastroenterol 2002 : 37 : 564 570.
34. Li SD, Yong S, Srinivas D, Van Thiel DH. Reactivation of sarcoidosis during interferon therapy. J Gastroenterol 2002 : 37 : 50 54.
35. Leveque L, de Boulard A, Bielefeld P, et al. Sarcoidosis during the treatment of hepatitis C by interferon-alpha and ribavirin: 2 cases. Rev Med Interne 2001 : 22 : 1248 1252.
36. Luchi S, Scasso A. Sarcoidosis, chronic hepatitis C and interferon-alpha: two cases. Scand J Infect Dis 2003 : 35 : 775 776.
37. Tahan V, Ozseker F, Guneylioglu D, et al. Sarcoidosis after use of interferon for chronic hepatitis C: report of a case and review of the literature. Dig Dis Sci 2003 : 48 : 169 173.
38. Rubinowitz AN, Naidich DP, Alinsonorin C. Interferon-induced sarcoidosis. J Comput Assist Tomogr 2003 : 27 : 279 283.
39. Leclerc S, Myers RP, Moussalli J, Herson S, Poynard T, Benveniste O. Sarcoidosis and interferon therapy: report of five cases and review of the literature. Eur J Intern Med 2003 : 14 : 237 243.
40. Tortorella C, Napoli N, Panella E, Antonaci A, Gentile A, Antonaci S. Asymptomatic systemic sarcoidosis arising 5 years after IFN-alpha treatment for chronic hepatitis C: a new challenge for clinicians. J Interferon Cytokine Res 2004 : 24 : 655 658.
41. Salvio A, Mormile M, Giannattasio F, et al. Pulmonary sarcoidosis during interferon therapy: a rare or underestimate event? Ann Ital Med Int 2004 : 19 : 58 62.
42. Menon Y, Cucurull E, Reisin E, Espinoza LR. Interferon-alpha-associated sarcoidosis responsive to infliximab therapy. Am J Med Sci 2004 : 328 : 173 175.
43. Werchniak AE, Cheng SX, Dhar AD, Klaus SN. Sarcoidosis presenting as tattoo changes in a patient undergoing treatment with interferon-alpha and ribavirin. Clin Exp Dermatol 2004 : 29 : 547 548.
44. Marzouk K, Saleh S, Kannass M, Sharma OP. Interferon-induced granulomatous lung disease. Curr Opin Pulm Med 2004 : 10 : 435 440.
45. Toulemonde A, Quereux G, Dreno B. Sarcoidosis granuloma on a tattoo induced by interferon alpha. Ann Dermatol Venereol 2004 : 131 : 49 51.
46. Rogers CJ, Romagosa R, Vincek V. Cutaneous sarcoidosis associated with pegylated interferon alfa and ribavirin therapy in a patient with chronic hepatitis C. J Am Acad Dermatol 2004 : 50 : 649 650.
47. Massaguer S, Sanchez M, Castel T. Mediastinal sarcoidosis induced by high-dose alpha-2-interferon therapy in a patient with malignant melanoma. Eur Radiol 2004 : 14 : 1716 1717.
48. Alfageme Michavila I, Merino Sanchez M, Perez Ronchel J, Lara Lara I, Suarez Garcia E, Lopez Garrido J Sarcoidosis following combined ribavirin and interferon therapy: a case report and review of the literature Arch Bronconeumol 2004 : 40 : 45 49.
49. Papaioannides D, Fotinou M, Korantzopoulos P, et al.Sarcoidosis associated with interferon-alpha therapy for chronic hepatitis C. Med Sci Monit 2004: 10: CS5-7.
50. Guilabert A, Bosch X, Julia M, Iranzo P,Mascaro JM Jr. Pegylated interferon alfa-induced sarcoidosis: two sides of the same coin. Br J Dermatol 2005: 152: 377-379.
51. Ramos-Casals M, Mana J, Nardi N, et al. Sarcoidosis in patients with chronic hepatitis C virus infection: analysis of 68 cases. Medicine 2005 : 84 : 69 80. (Pubitemid 40418635)
52. Tsiodras S, Drimala P, Stavreas N, Dachlythras M, Alamani AM, Naoum G. Uterine sarcoidosis potentially associated with interferon-alpha use for chronic hepatitis C infection. Obstet Gynecol 2005 : 105 : 1198 1201.
53. Butnor KJ. Pulmonary sarcoidosis induced by interferon-alpha therapy. Am J Surg Pathol 2005 : 29 : 976 979.
54. Hurst EA, Mauro T. Sarcoidosis associated with pegylated interferon alfa and ribavirin treatment for chronic hepatitis C: a case report and review of the literature. Arch Dermatol 2005 : 141 : 865 868.
55. Ubina-Aznar E, Fernandez-Moreno N, Rivera-Irigoin R, et al. Pulmonary sarcoidosis associated with pegylated interferon in the treatment of chronic hepatitis C. Gastroenterol Hepatol 2005 : 28 : 450 452.
56. Celik G, Sen E, Ulger AF, et al. Sarcoidosis caused by interferon therapy. Respirology 2005 : 10 : 535 540.
57. Hirano A, Kataoka M, Nakata Y, et al. Sarcoidosis occurring after interferon-alpha therapy for chronic hepatitis C: report of two cases. Respirology 2005 : 10 : 529 534.
58. Weyer P, Cummings OW, Knox KS. A 49-year-old woman with hepatitis, confusion, and abnormal chest radiograph findings. Chest 2005 Oct : 128 : 3076 3079.
59. Akay BN, Ekmekci P, Sanli H, Celik G, Bozdayi M. Cutaneous, pulmonary and hepatic sarcoidosis associated with autoimmune complications during interferon-alpha treatment for hepatitis C virus infection. J Eur Acad Dermatol Venereol 2006 : 20 : 442 445.
60. Goldberg HJ, Fiedler D, Webb A, Jagirdar J, Hoyumpa AM, Peters J. Sarcoidosis after treatment with interferon-alpha: a case series and review of the literature. Respir Med 2006 Nov : 100 : 2063 2068.
61. Perera GK, Calonje E. Systemic sarcoidosis presenting in a tattooed man undergoing treatment for hepatitis C. Clin Exp Dermatol 2006 : 31 : 387 389.
62. Benali S, Boustiere C, Castellani P, et al. Sarcoidosis following pegylated interferon therapy: two cases. Gastroenterol Clin Biol 2006 : 30 : 615 619.
63. Bolukbas C, Bolukbas FF, Kebdir T, et al. Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C - a case report and review of the literature. Acta Gastroenterol Belg 2005 : 68 : 432 434.
64. Doyle MK, Berggren R, Magnus JH. Interferon-induced sarcoidosis. J Clin Rheumatol 2006 : 12 : 241 248.