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Volumn 131, Issue 50, 2009, Pages 18038-18039

Duck-billed platypus venom peptides induce Ca2+ influx in neuroblastoma cells

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL EQUATIONS; CRUDE VENOMS; HEPTAPEPTIDES; HUMAN NEUROBLASTOMA; LINEAR FRAGMENTS; N-TERMINALS; NATRIURETIC PEPTIDES; NEUROBLASTOMA CELLS; PLATYPUS VENOM PEPTIDE;

EID: 72449184113     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja908148z     Document Type: Article
Times cited : (17)

References (28)
  • 1
    • 0006169650 scopus 로고
    • Bücherl, W., Buckley, E. A., Deulofen, V., Eds.; Academic Press: New York
    • (a) Calaby, J. H. In Venomous Animals and their Venoms, Volume 1; Bücherl, W., Buckley, E. A., Deulofen, V., Eds.; Academic Press: New York, 1968; pp 15-29.
    • (1968) Venomous Animals and Their Venoms, Volume 1 , pp. 15-29
    • Calaby, J.H.1
  • 13
    • 43449123631 scopus 로고    scopus 로고
    • (a) Warren, W. C.; et al. Nature 2008, 453, 175.
    • (2008) Nature , vol.453 , pp. 175
    • Warren, W.C.1
  • 17
  • 19
    • 72449174514 scopus 로고    scopus 로고
    • note
    • Fr. II strongly hydrolyzed Pro-Phe-Arg-MCA, a substrate of tissue kallikrein, and this peptidase activity was markedly suppressed by treatment with 10 μM aprotinin. These results suggested that the platypus venom had trypsin- or kallikrein-type proteolytic activity.
  • 20
    • 72449197242 scopus 로고    scopus 로고
    • For details, see Figures S1 and S16 in the Supporting Information
    • For details, see Figures S1 and S16 in the Supporting Information.
  • 22
    • 72449174046 scopus 로고    scopus 로고
    • note
    • The concentrations of peptides 1 and 4 in the venom fluid were 230 and 46 μM, respectively, as estimated by RP-HPLC analyses.
  • 24
    • 72449171248 scopus 로고    scopus 로고
    • note
    • 50 45 μM). Meanwhile, none of the peptides showed rat mast cell degranulation (1 mg/mL) or hemolytic activity against rabbit and sheep red blood cells (0.4 mg/mL).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.