Asymptomatic reactivation of JC virus in patients treated with natalizumab

New England Journal of Medicine

Volumn 361, Issue 25, 2009, Pages 2489-

  Warnke, Clemens ^a   Adams, Ortwin ^a   Kieseier, Bernd C ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; EDETIC ACID; NATALIZUMAB; VIRUS DNA;

CELL ISOLATION; CELL SEPARATION; CLINICAL PROTOCOL; DENSITY GRADIENT CENTRIFUGATION; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HUMAN; JC VIRUS; LETTER; MULTIPLE SCLEROSIS; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; REAL TIME POLYMERASE CHAIN REACTION; VIRUS REACTIVATION;

EID: 72449163936     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc0909049     Document Type: Letter

References (4)

1. Bonig H, Wundes A, Chang KH, Lucas S, Papayannopoulou T. Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab. Blood 2008;111:3439-3441
2. Zohren F, Toutzaris D, Klärner V, Hartung HP, Kieseier B, Haas R. The monoclonal anti-VLA-4 antibody natalizumab mobilizes CD34+ hematopoietic progenitor cells in humans. Blood 2008;111:3893-3895
3. Major EO. Reemergence of PML in natalizumab-treated patients - new cases, same concerns. N Engl J Med 2009;361:1041-1043
4. Ryschkewitsch C, Jensen P, Hou J, Fahle G, Fischer S, Major EO. Comparison of PCR-southern hybridization and quantitative real-time PCR for the detection of JC and BK viral nucleotide sequences in urine and cerebrospinal fluid. J Virol Methods 2004;121:217-221 (Pubitemid 39295712)