Computational analysis of oxygen transport in the retinal arterial network

Current Eye Research

Volumn 34, Issue 11, 2009, Pages 945-956

  Liu, D ^a   Wood, N B ^a   Witt, N ^a   Hughes, A D ^a   Thom, S A ^a   Xu, X Y ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Blood flow; Computer model; Imaging; Oxygen transport; Retinal circulation

Indexed keywords

ARTICLE; HEMODYNAMICS; HUMAN; NORMAL HUMAN; OPTIC DISK; OXYGEN CONSUMPTION; OXYGEN SATURATION; OXYGEN TENSION; OXYGEN TRANSPORT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETINA ARTERY; RETINA BLOOD FLOW; RETINA BLOOD VESSEL; RETINA IMAGE;

ARTERIOLES; BIOLOGICAL TRANSPORT; BLOOD FLOW VELOCITY; BLOOD PRESSURE; COMPUTER SIMULATION; HUMANS; LASER-DOPPLER FLOWMETRY; MATHEMATICS; OXYGEN; OXYGEN CONSUMPTION; PARTIAL PRESSURE; REGIONAL BLOOD FLOW; RETINAL ARTERY;

EID: 72449142263     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713680903230079     Document Type: Article

References (52)

1. Wang L, Tornquist P, Bill A. Glucose metabolism of the inner retina in pigs in darkness and light. Acta Physiologica Scandinavica. 1997;160:71-74. (Pubitemid 27223430)
2. Stanton AV, Wasan B, Cerutti A, Ford S, Marsh R, Sever PP, Thom SA, Hughes AD. Vascular network changes in the retina with age and hypertension. J Hypertension. 1995;13:1724-1728.
3. Wong TY, McIntosh R. Systemic associations of retinal microvascular signs: A review of recent population-based studies. Ophthalmic Physiol Optics. 2005;25:195-204.
4. Riva CE, Grunwald JE, Sinclair SH, Petrig BL. Blood velocity and volumetric flow rate in human retinal vessels. Invest Ophthalmol Vis Sci. 1985;26:1124-1132.
5. Harris A, Kagemann L, Cioffi GA. Assessment of human ocular hemodynamics. Surv Ophthalmol. 1998;42:509-533.
6. Wang Y, Bower BA, Izatt JA, Tan O, Huang D. In vivo total retinal blood flow measurement by Fourier domain Doppler optical coherence tomography. J Biomed Optics. 2007;12:041215.
7. Yu DY, Cringle SJ, Su E. Intraretinal oxygen distribution in the monkey retina and the response to systemic hyperxia. Invest Ophthalmol Vis Sci. 2005;46:4728-4733.
8. Yu DY, Cringle SJ. Oxygen distribution in the mouse retina. Invest Ophthalmol Vis Sci. 2006;47:1109-1112.
9. Schweitzer D, Hammer M, Kraft J, Thamm E, Konigsdorffer E, Strobel J. In vivo measurement of the oxygen saturation of retinal vessels in healthy volunteers. IEEE Trans Biomed Eng. 1999;46:1454-1465.
10. Michelson G, Scibor M. Intravascular oxygen saturation in retinal vessels in normal subjects and open-angle glaucoma subjects. Acta Ophthalmol Scand. 2006;84:289-295.
11. Kaazempur-Mofrad MR, Ethier CR. Mass transport in an anatomically realistic human right coronary artery. Ann Biomed Eng. 2001;29:121-127.
12. Qiu Y, Tarbell JM. Numerical simulation of oxygen mass transfer in a compliant curved tube model of a coronary artery. Ann Biomed Eng. 2000;28:26-38. (Pubitemid 30563032)
13. Moore JA, Ethier CR. Oxygen mass transfer calculations in large arteries. J Biomech Eng. 1997;119:469-475.
14. Sun N, Wood NB, Hughes AD, Thom S, Xu XY. Fluid-wall modelling of mass transfer in an axisymmetric stenosis: Effects of shear-dependent transport properties. Ann Biomed Eng. 2006;34:1119-1128.
15. Beard DA, Bassingthwaighte JB. Modeling advection and diffusion of oxygen in complex vascular networks. Ann Biomed Eng. 2001;29:298-310.
16. Tsoukias NM, Goldman D, Vadapalli A, Pittman RN, Popel AS. A computational model of oxygen delivery by hemoglobin-based oxygen carriers in three-dimensional microvascular networks. J Theor Biol. 2007;248:657-674.
17. Olufsen MS. A structured tree outflow condition for blood flow in the larger systemic arteries. Am J Physiol. 1999;276:H257-H268.
18. Olufsen MS, Peskin CS, Kim WY, Pedersen EM, Nadim A, Larsen J. Numerical simulation and experimental validation of blood flow in arteries with structuredtree outflow conditions. Ann Biomed Eng. 2000;28:1281-1299.
19. Steele BN, Olufsen MS, Taylor C. Fractal network model for simulating abdominal and lower extremity blood flow during resting and exercise conditions. Computer Methods in Biomech and Biomed Eng. 2007;10:39-51.
20. Martinez-Perez ME, Hughes AD, Stanton AV, Thom SA, Chapman N, Bharath AA, Parker KH. Retinal vascular tree morphology: A semi-automatic quantification. IEEE Trans on Biomed Eng. 2002;49:912-917.
21. Hubbard LD, Brothers RJ, King WN, Clegg LX, Klein R, Cooper LS, Richey Sharrett A, Davis MD, Cai J. Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the atherosclerosis risk in communities study. Ophthalmology. 1999;106:2269-2280.
22. Pries AR, Secomb TW, Gaehtgens P, Gross JF. Blood flow in microvascular networks-experiments and simulation. Circ Res. 1990;67:826-834.
23. Pries AR, Secomb TW, Gaehtgens P. Biophysical aspects of blood flow in the microvasculature. Cardiovascu Res. 1996;32:654-667.
24. Fung YC. Biomechanics, Mechanical Properties of Living Tissues. New York: Springer Verlag; 1993.
25. Iftimia NV, Hammer DX, Bigelow CE, Rosen DI, Ustun T, Ferrante AA, Vu D, Ferguson RD. Toward noninvasive measurement of blood hematocrit using spectral domain low coherence interferometry and retinal tracking. Optics Express. 2006;14:3377-3388.
26. Jensen PS, Gluckberg MR. Regional variation in capillary hemodynamics in the cat retina. Invest Ophthalmol Vis Sci. 1998;39:407-415.
27. Martinez-Perez ME. Computer Analysis of the Geometry of the Retinal Vasculature. PhD thesis, Imperial College London; 2000.
28. Zamir M, Medeiros JA. Arterial branching in man and monkey. J Gen Physiol. 1982;79:353-360.
29. Mendivil A, Cuartero V, Mendivil MP. Ocular blood flow velocities in patients with proliferative diabetic retinopathy and healthy volunteers: A prospective study. Br J Ophthalmol. 1995;79:413-416.
30. Dorner GT, Polska E, Garhofer G, Zawinka C, Frank B, Schmetterer L. Calculation of the diameter of the central retinal artery from noninvasive measurements in humans. Curr Eye Res. 2002;25:341-345.
31. Hardarson SH, Harris A, Karlsson RA, Halldorsson GH, Kagemann L, Rechtman E, Zoega GM, Eysteinsson T, Benediktsson JA, Thorsteinsson A, Jensen PK, Beach J, Stefansson E. Automatic retinal oximetry.Invest Ophthalmol Visual Sci. 2006;47:5011-5016.
32. Beach JM, Schwenzer KJ, Srinivas S, Kim D, Tiedeman JS. Oximetry of retinal vessels by dual-wavelength imaging: Calibration and influence of pigmentation. J Appl Physiol. 1999;86:748-758.
33. Delori FC. Noninvasive technique for oximetry of blood in retinal vessels. Appl Opt. 1988;27:1113-1125.
34. Buerk DG, Shonat RD, Riva CE, Cranstoun SD. O2 gradients and countercurrent exchange in the cat vitreous humor near retinal arterioles and venules. Microvasc Res. 1993;45:134-148.
35. Linsenmeier RA, Braun RD. Oxygen distribution and consumption in the cat retina during normoxia and hypoxemia. J Gen Physiol. 1992;99:177-197.
36. Birol G, Wang S, Budzynski E, Wangsa-Wirawan ND, Linsenmeier RA. Oxygen distribution and consumption in the macaque retina. Am J Physiol Heart Circ Physiol. 2007;293:H1696-H1704. (Pubitemid 47367217)
37. Cringle SJ, Yu DY, Yu PK, Su EN. Intraretinal oxygen consumption in the rat in vivo. Invest Ophthalmol Vis Sci. 2002;43:1922-1927.
38. Beard DA, Schenkman KA, Feigl EO. Myocardial oxygenation in isolated hearts predicted by an anatomically realistic microvascular transport model. Am J Physiol Heart Circ Physiol. 2003;285: H1826-H1836.
39. Roos MW. Theoretical estimation of retinal oxygenation during retinal artery occlusion. Physiol Meas. 2004;25: 1523-1532.
40. Goldman D, Popel AS. A computational study of the effect of capillary network anastomoses and tortuosity on oxygen transport. J Theor Biol. 2000;206:181-194.
41. Christoforides C, Laasberg LH, Hedley-Whyte J. Effect of temperature on solubility of O2 in human plasma. J Appl Physiol. 1969;26:56-60.
42. Altman PL, Dittmer DS. Respiration and circulation. Bethesda: Fed Am Soc Exp Biol. 1971;139.
43. Zheng L, Yipintsoi T, Bassingthwaighte JB. Nonlinear model for capillary-tissue oxygen transport and metabolism. Ann Biomed Eng. 1997;25:604-619.
44. Quigley M, Cohen S. A new pressure attenuation index to evaluate retinal circulation. Arch Ophthalmol. 1999;117: 84-89.
45. Fronek K, Zweifach BW. Microvascular pressure distribution in skeletal muscle and the effect of vasodilation.Am J Physiol. 1975;228:791-796.
46. Heistad DD. The Eugene M. Landis award lecture. Microcirculation 2001;8:365-375.
47. Glucksberg MR, Dunn R. Direct measurement of retinal microvascular pressures in the live, anesthetized cat. Microvasc Res. 1993;45:158-165.
48. Attariwala R, Giebs CP, Glucksberg MR. The Influence of elevated intraocular pressure on vascular pressures in the cat retina. Invest Ophthalmol Vis Sci. 1994;35:1019-1025.
49. Kobayashi H, Takizawa N, Tanishita K. Intravascular inhomogeneous distribution of oxygen in arterioles of rat cremaster muscle. Jpn J Physiol. 2002;52: 579-583. (Pubitemid 36362403)
50. Kobayashi H, Takizawa N. Imaging of oxygen transfer among microvessels of rat cremaster muscle. Circulation. 2002;105:1713-1719.
51. Caca I, Nazaroglu H, UnluK, Cakmak SS, Ari S, Sakalar YB. Color Doppler imaging of ocular hemodynamic changes in Behcet's cisease. Jpn J Ophthalmol. 2004;48:101-105.
52. Nemeth J, Knezy K, TapasztoB, Kovacs R, Harkanyi Z. Different autoregulation response to dynamic exercise in ophthalmic and central retinal arteries: A color Doppler study in healthy subjects. Graefes Arch Clin Exp Ophthalmol. 2002;240:835-840.