HMGA1 protein expression in familial breast carcinoma patients

European Journal of Cancer

Volumn 46, Issue 2, 2010, Pages 332-339

  Chiappetta, Gennaro ^a   Ottaiano, Alessandro ^a   Vuttariello, Emilia ^a   Monaco, Mario ^a   Galdiero, Francesca ^a   Gallipoli, Adolfo ^a   Pilotti, Silvana ^b   Jodice, Giovanna ^c   Siranoush, Manoukian ^b   Colombo, Mara ^b   Ripamonti, Carla B ^b   Pallante, Pier Lorenzo ^d   Radice, Paolo ^b,c   Fusco, Alfredo ^d  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^d CNR   (Italy)

Author keywords

BRCA1; BRCA2; Breast carcinoma; HMGA

Indexed keywords

HIGH MOBILITY GROUP A PROTEIN; HIGH MOBILITY GROUP A1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER SURVIVAL; FAMILIAL CANCER; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SURVIVAL RATE; SURVIVAL TIME; TUMOR SUPPRESSOR GENE;

ADULT; AGED; BREAST NEOPLASMS; FEMALE; GENES, BRCA1; GENES, BRCA2; GERM-LINE MUTATION; HMGA1A PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIERS ESTIMATE; MIDDLE AGED; NEOPLASM PROTEINS; PEDIGREE; YOUNG ADULT;

EID: 72449141796     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2009.10.015     Document Type: Article

References (30)

1. Claus E.B., Risch N., and Thompson W.D. Genetic analysis of breast cancer in the cancer and steroid hormone study. Am J Hum Genet 48 (1991) 232-242
2. Narod S., Ford D., Devilee P., et al. Genetic heterogeneity of breast-ovarian cancer revisited. Breast Cancer Linkage Consortium. Am J Hum Genet 57 (1995) 957-958
3. Peto J., Collins N., Barfoot R., et al. Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst 91 (1999) 943-949
4. Marcus J.N., Watson P., Page D.L., et al. Hereditary breast cancer: pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage. Cancer 77 (1996) 697-709
5. Marcus J.N., Watson P., Page D.L., et al. BRCA2 hereditary breast cancer pathophenotype. Breast Cancer Res Treat 44 (1997) 275-277
6. Armes J.E., Egan A.J., Southey M.C., et al. The histologic phenotypes of breast carcinoma occurring before age 40 years in women with and without BRCA1 or BRCA2 germline mutations: a population-based study. Cancer 83 (1998) 2335-2345
7. Grosschedl R., Giese K., and Pagel J. HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. Trends Genet 10 (1994) 94-100
8. Reeves R., and Nissen M.S. The A-T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure. J Biol Chem 265 (1990) 8573-8582
9. Reeves R. Structure and function of the HMGI(Y) family of architectural transcription factors. Environ Health Perspect 108 (2000) 803-809
10. Chiappetta G., Avvantaggiato V., Visconti R., et al. High level expression of the HMGA1 gene during embryonic development. Oncogene 13 (1996) 2439-2446
11. Abe N., Watanabe T., Masaki T., et al. Pancreatic duct cell carcinomas express high levels of high mobility group I(Y) proteins. Cancer Res 60 (2000) 3117-3122
12. Chiappetta G., Tallini G., De Biasio M.C., et al. Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma. Cancer Res 58 (1998) 4193-4198
13. Chiappetta G., Manfioletti G., Pentimalli F., et al. High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases. Int J Cancer 91 (2001) 147-151
14. Chiappetta G., Botti G., Monaco M., et al. HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression. Clin Cancer Res 10 (2004) 7637-7644
15. Meyer B., Loeschke S., Schultze A., et al. HMGA2 overexpression in non-small cell lung cancer. Mol Carcinogen 46 (2007) 503-511
16. Masciullo V., Baldassarre G., Pentimalli F., et al. HMGA1 protein over-expression is a frequent feature of epithelial ovarian carcinomas. Carcinogenesis 24 (2003) 1191-1198
17. Tamimi Y., Vander Poel H.G., Denyn M.M., et al. Increased expression of high mobility group protein I(Y) in high grade prostatic cancer determined by in situ hybridization. Cancer Res 53 (1993) 5512-5516
18. Miyazawa J., Mitoro A., Kawashiri S., Chada K.K., and Imai K. Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity. Cancer Res 15 (2004) 2024-2029
19. Rho Y.S., Lim Y.C., Park I.S., et al. High mobility group HMGI(Y) protein expression in head and neck squamous cell carcinoma. Acta Otolaryngol 127 (2007) 76-81
20. Abe N., Watanabe T., Izumisato Y., et al. High mobility group A1 is expressed in metastatic adenocarcinoma to the liver and intrahepatic cholangiocarcinoma, but not in hepatocellular carcinoma: its potential use in the diagnosis of liver neoplasms. J Gastroenterol 38 (2003) 1144-1149
21. Berlingieri M.T., Manfioletti G., Santoro M., et al. Inhibition of HMGI-C protein synthesis suppresses retrovirally induced neoplastic transformation of rat thyroid cells. Mol Cell Biol 15 (1995) 1545-1553
22. Wood L.J., Maher J.F., Bunton T.E., and Resar L.M. The oncogenic properties of the HMG-I gene family. Cancer Res 60 15 (2000) 4256-4261
23. Baldassarre G., Battista S., Belletti B., et al. Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma. Mol Cell Biol 23 (2003) 2225-2238
24. Manoukian S., Peissel B., Pensotti V., et al. Germline TP53 and BRCA2 mutations in breast cancer/sarcoma families. Eur J Cancer 43 (2007) 601-606
25. Wagner T.M., Moslinger R.A., Muhr D., et al. BRCA1-related breast cancer in Austrian breast and ovarian cancer families: specific BRCA1 mutations and pathological characteristics. Int J Cancer 77 (1998) 354-360
26. Wagner T.M., Hirtenlehner K., Shen P., et al. Global sequence diversity of BRCA2: analysis of 71 breast cancer families and 95 control individuals of worldwide populations. Hum Mol Genet 8 (1999) 413-423
27. Colombo M., Giarola M., Mariani L., et al. Cyclin D1 expression analysis in familial breast cancers may discriminate BRCAX from BRCA2-linked cases. Mod Pathol 21 10 (2008) 1262-1270
28. Chiappetta G., Bandiera A., Berlingieri M.T., et al. The expression of the high mobility group HMGI(Y) proteins correlates with the malignant phenotype of human thyroid neoplasms. Oncogene 10 (1995) 1307-1314
29. Fedele M., Pentimalli F., et al. Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. Oncogene 24 21 (2005) 3427-3435
30. Fedele M., Fidanza V., Battista S., et al. Aploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice. Cancer Res 66 5 (2006) 2536-2543