Antipneumococcal activities of two novel macrolides, GW 773546 and GW 708408, compared with those of erythromycin, azithromycin, clarithromycin, clindamycin, and telithromycin

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 11, 2004, Pages 4103-4112

  Matic, Vlatka ^a   Kosowska, Klaudia ^a   Bozdogan, Bulent ^a   Kelly, Linda M ^a   Smith, Kathy ^a   Ednie, Lois M ^a   Lin, Gengrong ^a   Credito, Kim L ^a   Clark, Catherine L ^a   McGhee, Pamela ^a   Pankuch, Glenn A ^a   Jacobs, Michael R ^b   Appelbaum, Peter C ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CLARITHROMYCIN; CLINDAMYCIN; ERYTHROMYCIN; GW 708408; GW 773546; L22 PROTEIN; L4 PROTEIN; MACROLIDE; RIBOSOME PROTEIN; RNA 23S; TELITHROMYCIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; COMPARATIVE STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RNA SEQUENCE; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CLARITHROMYCIN; CLINDAMYCIN; DRUG RESISTANCE, BACTERIAL; ERYTHROMYCIN; GENES, BACTERIAL; KETOLIDES; MACROLIDES; MICROBIAL SENSITIVITY TESTS; MUTATION; STREPTOCOCCUS PNEUMONIAE; TIME FACTORS;

EID: 7244247154     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.11.4103-4112.2004     Document Type: Article

References (33)

1. Appelbaum, P. C. 1992. Antimicrobial resistance in Streptococcus pneumoniae-an overview. Clin. Infect. Dis. 15:77-83.
2. Block, S., C. J. Harrison, J. A. Hedrick, R. D. Tyler, R. A. Smith, E. Keegan, and S. A. Chartrand. 1995. Penicillin-resistant Streptococcus pneumoniae in acute otitis media: risk factors, susceptibility patterns and antimicrobial management. Pediatr. Infect. Dis. J. 14:751-759.
3. Bozdogan, B., P. C. Appelbaum, L. M. Kelly, D. B. Hoellman, A. Tambic-Andrasevic, L. Drukalska, W. Hryniewicz, H. Hupkova, M. R. Jacobs, J. Kolman, M. Konkoly-Thege, J. Miciuleviciene, M. Pana, L. Setchanova, J. Trupl, and P. Urbaskova. 2003. Activity of telithromycin and seven other agents against 1034 pediatric Streptococcus pneumoniae isolates from ten Central and Eastern European centers. Clin. Microbiol. Infect. 9:653-661.
4. Breiman, R. F., J. C. Butler, F. C. Tenover, J. A. Elliott, and R. R. Facklam. 1994. Emergence of drug-resistant pneumococcal infections in the United States. JAMA 271:1831-1835.
5. Canu, A., B. Malbruny, M. Coquemont, T. A. Davies, P. C. Appelbaum, and R. Leclercq. 2002. Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 46:125-131.
6. Davies, T. A., B. E. Dewasse, M. R. Jacobs, and P. C. Appelbaum. 2000. In vitro development of resistance to telithromycin (HMR 3647), four macrolides, clindamycin, and pristinamycin in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 44:414-417.
7. Davies, T. A., L. M. Ednie, D. B. Hoellman, G. A. Pankuch, M. R. Jacobs, and P. C. Appelbaum. 2000. Antipneumococcal activity of ABT-773 compared to those of 10 other agents. Antimicrob. Agents Chemother. 44:1894-1899.
8. Hoban, D., K. Waites, and D. Felmingham. 2003. Antimicrobial susceptibility of community-acquired respiratory tract pathogens in North America in 1999-2000: Findings of the PROTEKT surveillance study. Diagn. Microbiol. Infect. Dis. 45:251-259.
9. Ioannidou, S., P. T. Tassios, L. Zachariadou, Z. Salem, M. Kanelopoulou, S. Kanavaki, G. Chronopoulou, N. Petropoulou, M. Foustoukou, A. Pangalis, E. Trikka-Graphakos, E. Papafraggas, and A. C. Vatopoulos. 2003. In vitro activity of telithromycin (HMR 3647) against Greek Streptococcus pyogenes and Streptococcus pneumoniae clinical isolates with different macrolide susceptibilities. Clin. Microbiol. Infect. 9:704.
10. Jacobs, M. R. 1992. Treatment and diagnosis of infections caused by drug-resistant Streptococcus pneumoniae. Clin. Infect. Dis. 15:119-127.
11. Jacobs, M. R., and P. C. Appelbaum. 1999. Streptococcus pneumoniae: activity of newer agents against penicillin-resistant strains. Curr. Infect. Dis. Rep. 1:13-21.
12. Jacobs, M. R., S. Bajaksouzian, and P. C. Appelbaum. 2003. Telithromycin post-antibiotic and post-antibiotic sub-MIC effects for 10 gram-positive cocci. J. Antimicrob. Chemother. 52:809-812.
13. Jacobs, M. R., S. Bajaksouzian, A. Zilles, G. Lin, G. A. Pankuch, and P. C. Appelbaum. 1999. Susceptibilities of Streptococcus pneumoniae and Haemophilus influenzae to 10 oral antimicrobial agents based on pharmacodynamic parameters: 1997 U.S. surveillance study. Antimicrob. Agents Chemother. 43:1901-1908.
14. Jacobs, M. R., D. Felmingham, F. C. Appelbaum, R. N. Grueneberg, and the Alexander Project Group. 2003. The Alexander Project 1998-2000: Susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agents. J. Antimicrob. Chemother. 52:229-246.
15. Kohno, S., D. Hoban, and the Protekt Surveillance Study Group. 2003. Comparative in vitro activity of telithromycin and beta-lactam antimicrobials against bacterial pathogens from community-acquired respiratory tract infections: data from the first year of PROTEKT (1999-2000). J. Chemother. 15:335-341.
16. Kozlov, R., T. M. Bogdanovitch, P. C. Appelbaum, L. Ednie, L. S. Stratchounski. M. R. Jacobs, and B. Bozdogan. 2002. Antistreptococcal activity of telithromycin compared with seven other drugs in relation to macrolide resistance mechanisms in Russia. Antimicrob. Agents Chemother. 46:2963-2968.
17. Leclercq, R., L. Nantas, C. J. Soussy, and J. Duval. 1992. Activity of RP 59500, a new parenteral semisynthetic streptogramin, against staphylococci with various mechanisms of resistance to macrolide-lincosamide-streptogramin antibiotics. J. Antimicrob Chemother. 30(Suppl. A):67-75.
18. Mason, E. O., Jr., L. B. Lamberth, N. L. Kershaw, B. L. Presser, A. Zoe, and P. G. Ambrose. 2000. Streptococcus pneumoniae in the USA: in vitro susceptibility and pharmacodynamic analysis. J. Antimicrob. Chemother. 45:623-631.
19. McDougal, L. K., R. Facklam, M. Reeves, S. Hunter, J. M. Swenson, B. C. Hill, and F. C. Tenover. 1992. Analysis of multiply antimicrobial-resistant isolates of Streptococcus pneumoniae from the United States. Antimicrob. Agents Chemother. 36:2176-2184.
20. Munoz, R, J. M. Musser, M. Crain, D. E. Briles, A. Marton, A. J. Parkinson, U. Sorensen, and A. Tomasz. 1992. Geographic distribution of penicillin-resistant clones of Streptococcus pneumoniae: characterization by penicillin-binding protein profile, surface protein A typing, and multilocus enzyme analysis. Clin. Infect. Dis. 15:112-118.
21. Musher, D. M., M. E. Dowell, V. D. Shortridge, R. K. Flamm, J. H. Jorgensen, P. L. le Magueres, and K. L. Krause. 2002. Emergence of macrolide resistance during treatment of pneumococcal pneumonia. N. Engl. J. Med. 346:630-631.
22. Nagai, K., P. C. Appelbaum, T. A. Davies, L. M. Kelly, D. B. Hoellman, A. T. Andrasevic, L. Drukalska, W. Hryniewicz, M. R. Jacobs, J. Kolman, J. Miculeviciene, M. Pana, L. Setchanova, M. K. Thege, H. Hupkova, J. Trupl, and P. Urbaskova. 2002. Susceptibilities to telithromycin and six other agents and prevalence of macrolide resistance due to L4 ribosomal protein mutation among 992 pneumococci from 10 Central and Eastern European countries. Antimicrob. Agents Chemother. 46:371-377.
23. Nagai, K., T. A. Davies, G. A. Pankuch, B. E. DeWasse, M. R. Jacobs, and P. C. Appelbaum. 2000. In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 44:2740-2746.
24. National Committee for Clinical Laboratory Standards. 2003. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 6th ed.; approved standard. NCCLS publication M7-A6. National Committee for Clinical Laboratory Standards, Wayne, Pa.
25. Pankuch, G. A., M. R. Jacobs, and P. C. Appelbaum. 1994. Study of comparative antipneumococcal activities of penicillin G, RP 59500, erythromycin, sparfloxacin, ciprofloxacin, and vancomycin by using time-kill methodology. Antimicrob. Agents Chemother. 38:2065-2072.
26. Pankuch, G. A., S. A. Juenemann, T. A. Davies, M. R. Jacobs, and P. C. Appelbaum. 1998. In vitro selection of resistance to four β-lactams and azithromycin in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 42:2914-2918.
27. Pankuch, G. A., M. A. Visalli, M. R. Jacobs, and P. C. Appelbaum. 1998. Susceptibilities of penicillin- and erythromycin-susceptible and -resistant pneumococci to HMR 3647 (RU 66647), a new ketolide, compared with susceptibilities to 17 other agents. Antimicrob. Agents Chemother. 42:624-630.
28. Reinert, R. R., A. Wild, P. Appelbaum, R. Lütticken, M. Y. Cil, and A. Al-Lahham. 2003. Ribosomal mutations conferring resistance to macrolides in Streptococcus pneumoniae clinical strains isolated in Germany. Antimicrob. Agents Chemother. 47:2319-2322.
29. Sanchez, M. L., K. K. Flint, and R. N. Jones. 1993. Occurrence of macrolidelincosamide-streptogramin resistances among staphylococcal clinical isolates at a university medical center. Is false susceptibility to new macrolides and clindamycin a contemporary clinical and in vitro testing problem? Diagn. Microbiol. Infect. Dis. 16:205-213.
30. Schito, A. M., G. C. Schito, E. Debbia, G. Russo, J. Linares, E. Cercenado, and E. J. Bouza. 2003. Antibacterial resistance in Streptococcus pneumoniae and Haemophilus influenzae from Italy and Spain: data from the PROTEKT surveillance study, 1999-2000. J. Chemother. 15:226-234.
31. Sutcliffe, J., T. Grebe, A. Tait-Kamradt. and L. Wondrack. 1996. Detection of erythromycin-resistant determinants by PCR. Antimicrob. Agents Chemother. 40:2562-2566.
32. Ubukata, K., S. Iwata, and K. Sunakawa. 2003. In vitro activities of new ketolide, telithromycin, and eight other macrolide antibiotics against Streptococcus pneumoniae having mefA and ermB genes that mediate macrolide resistance. J. Infect. Chemother. 9:221-226.
33. Walsh, F., J. Willcock, and S. Amyes. 2003. High-level resistance in laboratory-generated mutants of Streptococcus pneumoniae. J. Antimicrob. Chemother. 52:345-353.