Characterization of Hemoglobin Bassett (α94Asp→Ala), a variant with very low oxygen affinity

American Journal of Hematology

Volumn 77, Issue 3, 2004, Pages 268-276

  Abdulmalik, Osheiza ^a   Safo, Martin K ^b   Lerner, Norma B ^c   Ochotorena, Josiree ^d   Daikhin, Evgueni ^a   Lakka, Vinaysagar ^a   Santacroce, Rosa ^e   Abraham, Donald J ^b   Asakura, Toshio ^a,f  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d Child and Adol Health Associates   (United States)

^e CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Globin; Hemoglobin disorders; Hemoglobinopathies; Oxygen affinity

Indexed keywords

ALANINE; ALPHA GLOBIN; ASPARTIC ACID; HEMOGLOBIN BASSETT; HEMOGLOBIN CHAIN; HEMOGLOBIN VARIANT; OXYGEN; PEPTIDE; TRYPSIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BOHR EFFECT; CASE REPORT; CAUCASIAN; CYANOSIS; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; ENZYMATIC DEGRADATION; GENE MUTATION; HEMOGLOBIN ANALYSIS; HUMAN; ION EXCHANGE CHROMATOGRAPHY; MALE; OXYGEN AFFINITY; PEPTIDE ANALYSIS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; X RAY CRYSTALLOGRAPHY;

ALANINE; AMINO ACID SUBSTITUTION; ASPARTIC ACID; CHILD; CHROMATOGRAPHY, ION EXCHANGE; CRYSTALLOGRAPHY, X-RAY; HEMOGLOBIN A; HEMOGLOBINS, ABNORMAL; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MODELS, MOLECULAR; MUTATION; OXYGEN; OXYHEMOGLOBINS; PARTIAL PRESSURE; PROTEIN SUBUNITS;

EID: 7244247016     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.20184     Document Type: Article

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