Radiotherapy-based conditioning is effective immunosuppression for patients undergoing transplantation with T-cell depleted stem cell grafts for severe aplasia

Cytotherapy

Volumn 6, Issue 5, 2004, Pages 450-456

  Novitzky, N ^a,d   Thomas, V ^a   Stubbings, H ^b   Hale, G ^c   Waldmann, H ^c  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Aplastic anemia; CD52; GvHD; T cell depletion; Total lymphoid irradiation

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; ALEMTUZUMAB; ANTIBIOTIC AGENT; CD34 ANTIGEN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTOKINE; GANCICLOVIR; PREDNISONE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE DISEASE; ADOLESCENT; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; APLASTIC ANEMIA; ARTICLE; BLOOD CELL COUNT; CAUSE OF DEATH; CHIMERA; CHRONIC DISEASE; CLINICAL ARTICLE; COHORT ANALYSIS; CYTOMEGALOVIRUS INFECTION; DIGESTIVE SYSTEM INJURY; DISEASE SEVERITY; DRUG FATALITY; ERYTHROCYTE TRANSFUSION; FEMALE; FEVER; GRAFT FAILURE; GRAFT VERSUS HOST REACTION; HEMATOLOGIC DISEASE; HEMATOPOIESIS; HEMORRHAGIC CYSTITIS; HLA MATCHING; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LYMPH NODE IRRADIATION; LYMPHOCYTE COUNT; LYMPHOCYTE DEPLETION; MALE; MUCOSA INFLAMMATION; NEPHROTOXICITY; PLASMAPHERESIS; RADIATION DOSE FRACTIONATION; SEPSIS; SEPTICEMIA; SIBLING; STEM CELL MOBILIZATION; SURVIVAL TIME; T LYMPHOCYTE; THROMBOTIC THROMBOCYTOPENIC PURPURA; TREATMENT OUTCOME; WHOLE BODY RADIATION;

EID: 7244231223     PISSN: 14653249     EISSN: None     Source Type: Journal    
DOI: 10.1080/14653240410004970     Document Type: Article

References (25)

1. Camitta BM, Thomas ED, Nathan DG et al. A prospective study of androgens and bone marrow transplantation for treatment of severe aplastic anemia. Blood 1979;53:504-14.
2. Camitta BM, Thomas ED, Nathan DG et al. Severe aplastic anemia: a prospective study of the effect of early marrow transplantation on acute mortality. Blood 1976;48:63-70.
3. Bacigalupo A, Oneto R, Bruno B et al. Current results of bone marrow transplantation in patients with acquired severe aplastic anemia. Report of the European Group for Blood and Marrow transplantation. On behalf of the Working Party on Severe Aplastic Anemia of the European Group for Blood and Marrow Transplantation. Acta Haematol 2000;103:19-25.
4. Storb RK, Blume G, O'Donnell MR et al. Cyclophosphamide and antithymocyte globulin to condition patients with aplastic anemia for allogeneic marrow transplantations: the experience in four centers. Biol Blood Marrow Transplant 2001;7:39-44.
5. Castro-Malaspina Childs H, Laver B, Shank B et al. Hyperfractionated total lymphoid irradiation and cyclophosphamide for preparation of previously transfused patients undergoing HLA-identical marrow transplantation for severe aplastic anemia. Int J Rad Oncol Biol Phys 1994;29:847-54.
6. Storb R, Etzioni R, Anasetti C et al. Cyclophosphamide combined with antithymocyte globulin in preparation for allogeneic marrow transplants in patients with aplastic anemia. Blood 1994;84:941-9.
7. Jacobs P, Wood L, Fullard L et al. T cell depletion by exposure to Campath-1G in vitro prevents graft-versus-host disease. Bone Marrow Transplant 1994;13:763-9.
8. + cell determination by flow cytometry. J Hematother 1996;5:213-26.
9. Hale G, Xia M-Q, Tighe HP et al. The CAMPATH-1 antigen (CDw 52). Tissue Antigens 1990;35:118-27.
10. Hale G, Waldmann H. Control of graft-versus-host disease and graft rejection by T cell depletion of donor and recipient with Campath-1 antibodies. Results of matched sibling transplants for malignant diseases. Bone Marrow Transplant 1994;13:597-611.
11. Phillips J, Drumm A, Harrison P et al. Manufacture and quality control of CAMPATH-1 antibodies for clinical trials. Cytotherapy 2001;3:233-42.
12. Glucksberg H, Storb R, Fefer A et al. Clinical manifestations of graft vs. host disease in human recipients of marrow from HLA matched sibling donors. Transplantation 1974;18:295-301.
13. Conill C, Verger E, Salamero M. Performance status assessment in cancer patients. Cancer 1990;65:1864-6.
14. Storb R, Deeg HJ, Farewell V et al. Marrow transplantation for severe aplastic anemia: methotrexate alone compared with a combination of methotrexate and cyclosporine for prevention of acute graft-versus-host disease. Blood 1986;68:119-25.
15. Deeg HJ, Leisenring W, Storb R et al. Long-term outcome after marrow transplantation for severe aplastic anemia. Blood 1998;91:3637-45.
16. Min CK, Kim DD, Lee JW et al. Hematopoietic stem cell transplantation for high-risk adult patients with severe aplastic anemia; reduction of graft failure by enhancing stem cell dose. Haematologica 2001;86:303-10.
17. Kroger NT, Zabelina H, Renges W et al. Long-term follow-up of allogeneic stem cell transplantation in patients with severe aplastic anemia after conditioning with cyclophosphamide plus anti-thymocyte globulin. Ann Hematol 2002;81:627-31.
18. Hale G, Cobbold S, Novitzky N et al. CAMPATH-1 antibodies in stem cell transplantation. Cytotherapy 2001; 3:145-64.
19. Novitzky N, Thomas V, Hale G, Waldmann H. CAMPATH-1 antibodies 'in the bag' for haematological malignancies: the Cape Town experience. Cytotherapy 2004;6:172-81.
20. Deeg HJ, Amylon ID, Harris RE et al. Marrow transplants from unrelated donors for patients with aplastic anemia: minimum effective dose of total body irradiation. Biol Blood Marrow Transplant 2001;7:208-15.
21. Tzeng CH, Chen PM, Fan S et al. CY/TBI-800 as a pretransplant regimen for allogeneic bone marrow transplantation for severe aplastic anemia using HLA-haploidentical family donors. Bone Marrow Transplant 1996;18:273-7.
22. Ades L, Mary JY, Robin M et al. Long-term outcome after bone marrow transplantation for severe aplastic anemia. Blood 2004;103:2490-7.
23. Deeg HJ, Socie G, Schoch G et al. Malignancies after marrow transplantation for aplastic anemia and Fanconi anemia: a joint Settle and Paris analysis of result in 700 patients. Blood 1996;87:386-92.
24. Kolb HJ, Socie G, Duell et al. Malignant neoplasm in long-term survivors of bone marrow transplantation. Late Effects Working of the European Coopertive Group for Blood and Marrow Transpalantation and the European Late Effect Project Group. Am Intern Med 1999;131:738-44
25. Eapen M, Ramsay NK, Mertens AC et al. Late outcomes after bone marrow trnsplant for aplastic anaemia. Br J Haematol 2001;111:754-60.