Effects of trilostane on the pituitary-adrenocortical and renin-aldosterone axis in dogs with pituitary-dependent hypercortisolism

Veterinary Journal

Volumn 183, Issue 1, 2010, Pages 75-80

  Galac, Sara ^a   Buijtels, Jenny J C W M ^a   Mol, Jan A ^a   Kooistra, Hans S ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

ACTH; Canine; Cortisol; Cushing's disease; Plasma renin activity

Indexed keywords

ALDOSTERONE; CORTICOTROPIN; CORTISONE ACETATE; HYDROCORTISONE; TRILOSTANE;

ADRENAL CORTEX INSUFFICIENCY; ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; CORTICOTROPIN TEST; CUSHING DISEASE; DOG DISEASE; DOSE TIME EFFECT RELATION; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; FEMALE; HYDROCORTISONE BLOOD LEVEL; HYPERCORTISOLISM; HYPOCORTISOLISM; HYPOPHYSIS ADRENAL SYSTEM; MALE; NONHUMAN; OPTIMAL DRUG DOSE; PLASMA RENIN ACTIVITY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ADRENOCORTICOTROPIC HORMONE; ALDOSTERONE; ANIMALS; DIHYDROTESTOSTERONE; DOG DISEASES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PITUITARY ACTH HYPERSECRETION; PITUITARY-ADRENAL SYSTEM; RENIN; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

CANIS FAMILIARIS;

EID: 72249111347     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2008.10.007     Document Type: Article

References (33)

1. Bell R., Neiger R., McGrotty Y., and Ramsey I.K. Study of the effects of once daily doses of trilostane on cortisol concentrations and responsiveness to adrenocorticotrophic hormone in hyperadrenocorticoid dogs. Veterinary Record 159 (2006) 277-281
2. Boer P., Hene R.J., Koomans H.A., Nieuwenhuis M.G., Geyskes G.G., and Mees E.J. Blood and extracellular fluid volume in patients with Bartter's syndrome. Archives of Internal Medicine 143 (1983) 1902-1905
3. Braddock J.A., Church D.B., Robertson I.D., and Watson A.D. Trilostane treatment in dogs with pituitary-dependent hyperadrenocorticism. Australian Veterinary Journal 81 (2003) 600-607
4. Chapman P.S., Kelly D.F., Archer J., Brokman D.J., and Niger R. Adrenal necrosis in a dog receiving trilostane for the treatment of hyperadrenocorticism. The Journal of Small Animal Practice 45 (2004) 307-310
5. Den Hertog E., Braakman J.C.A., Teske E., Kooistra H.S., and Rijnberk A. Results of non-selective adrenocorticolysis by o, p′-DDD in 129 dogs with pituitary-dependent hyperadrenocorticism. Veterinary Record 144 (1999) 12-17
6. Frank L.A., Davis J.A., and Oliver J.W. Serum concentrations of cortisol, sex hormones of adrenal origin, and adrenocortical steroid intermediates in healthy dogs following stimulation with two doses of cosyntropin. American Journal of Veterinary Research 65 (2004) 1631-1633
7. Galac S., Kooistra H.S., Teske E., and Rijnberk A. Urinary corticoid/creatinine ratios in the differentiation between pituitary-dependent hyperadrenocorticism and hyperadrenocorticism due to adrenocortical tumour in the dog. Veterinary Quarterly 19 (1997) 17-20
8. Galac S., Kooistra H.S., Voorhout G., van den Ingh T.S.G.A.M., Mol J.A., van den Bergh G., and Meij B.P. Hyperadrenocorticism in a dog due to ectopic secretion of adrenocorticotropic hormone. Domestic Animal Endocrinology 28 (2005) 338-348
9. Javadi S., Kooistra H.S., Mol J.A., Boer P., Boer W.H., and Rijnberk A. Plasma aldosterone concentration and plasma renin activity in healthy dogs and in dogs with hyperadrenocorticism. Veterinary Record 153 (2003) 521-525
10. Javadi S., Galac S., Boer P., Robben J.H., Teske E., and Kooistra H.S. Aldosterone to renin ratio and cortisol to adrenocorticotropic hormone ratio in healthy dogs and dogs with primary hypoadrenocorticism. Journal of Veterinary Internal Medicine 20 (2006) 556-561
11. Javadi S., Djajadiningrat-Laanen S.C., Kooistra H.S., van Dongen A.M., Voorhout G., van Sluijs F.J., van den Ingh T.E., Boer W.H., and Rijnberk A. Primary hyperaldosteronism, a mediator of progressive renal disease in cats. Domestic Animal Endocrinology 28 (2005) 85-104
12. Kintzer P.P., and Peterson M.E. Mitotane (o, p′-DDD) treatment of 200 dogs with pituitary-dependent hyperadrenocorticism. Journal of the American Veterinary Medical Association 5 (1991) 182-190
13. Komanicky P., Spark R.F., and Melby J.C. Treatment of Cushing's syndrome with trilostane (WIN 24, 540), an inhibitor of adrenal steroid biosynthesis. The Journal of Clinical Endocrinology Metabolism 47 (1978) 1042-1051
14. Kornbluth A.A., Salomon P., Sachar D.B., Subramani K., Kramer A., Gray C.E., Present D.H., and Chapman M.L. ACTH-induced adrenal hemorrhage: a complication of therapy masquerading as an acute abdomen. Journal of Clinical Gastroenterology 12 (1990) 371-377
15. Levin T.L., and Morton E. Adrenal hemorrhage complicating ACTH therapy in Crohn's disease. Pediatric Radiology 23 (1993) 457-458
16. Lim P.O., Rodgers P., Cardale K., Watson A.D., and MacDonald T.M. Potentially high prevalence of primary aldosteronism in a primary-care population. Lancet 353 (1999) 1013-1014
17. Loriaux D.L. Adrenocortical insufficiency. In: Becker K.L. (Ed). Principles and Practice of Endocrinology and Metabolism (2001), Lippincott Williams and Wilkins, Philadelphia PA, USA 739-743
18. Meij B.P., Voorhout G., and Rjnberk A. Progress in transsphenoidal hypophysectomy for treatment of pituitary-dependent hyperadrenocorticism in dogs and cats. Molecular and Cellular Endocrinology 197 (2002) 89-96
19. Neiger R., Ramsey I.K., O'Connor J., Hurley K.J., and Mooney C.T. Trilostane treatment of 78 dogs with pituitary-dependent hyperadrenocorticism. Veterinary Record 150 (2002) 799-804
20. Peterson M.E., Kintzer P.P., and Kass P.H. Pretreatment clinical and laboratory findings in dogs with hyperadrenocorticism: 225 cases (1979-1993). Journal of the American Veterinary Medical Association 208 (1996) 85-91
21. Potts G.O., Creange J.E., Hardong H.R., and Schane H.P. Trilostane, an orally active inhibitor of steroid biosynthesis. Steroids 32 (1978) 257-267
22. Pudney J., Price G.M., Whitehouse B.J., and Vinson G.P. Effects of chronic ACTH stimulation on the morphology of the rat adrenal cortex. Anatomical Record 210 (1984) 603-615
23. Reusch C.E., Sieber-Ruckstuhl N., Wenger M., Luts H., Perren A., and Pospischil A. Histological evaluation of the adrenal glands of seven dogs with hyperadrenocorticism treated with trilostane. Veterinary Record 160 (2007) 219-224
24. Rijnberk A., van Wees A., and Mol J.A. Assessment of two tests for the diagnosis of canine hyperadrenocorticism. Veterinary Record 122 (1988) 178-180
25. Rijnberk A. Adrenals. In: Rijnberk A. (Ed). Clinical Endocrinology of Dogs and Cats (1996), Kluwer Academic Publishers, Doordrecht, The Netherlands 61-93
26. Ruckstuhl N.S., Nett C.S., and Reusch C.E. Results of clinical examinations, laboratory tests, and ultrasonography in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane. American Journal of Veterinary Research 63 (2002) 506-512
27. Russcher H., Smit P., van Rossum E.F., Brinkman A.O., de Jong F.H., Hokken A., Pols H.A., Kopper J.W., and Lamberts J.W. Strategies for the characterization of disorders in cortisol sensitivity. Journal of Clinical Endocrinology and Metabolism 91 (2006) 694-701
28. Sieber-Ruckstuhl N.S., Boretti M.S., Wenger M., Maser-Gluth C., and Reusch C.E. Cortisol, aldosterone, cortisol precursor, androgen and endogenous ACTH concentrations in dogs with pituitary-dependant hyperadrenocorticism treated with trilostane. Domestic Animal Endocrinology 31 (2006) 63-75
29. Stolp R., Rijnberk A., Meijer J.C., and Croughs R.J. Urinary corticoids in the diagnosis of canine hyperadrenocorticism. Research in Veterinary Science 34 (1983) 141-144
30. Van Vonderen I.K., Kooistra H.S., and Rijnberk A. Influence of veterinary care on the urinary corticoid:creatinine ratio in dogs. Journal of Veterinary Internal Medicine 12 (1998) 431-435
31. Vermeer H., Hendriks-Stegeman B.I., van Suylekom D., Rijkers G.T., van Bull-Offers S.C., and Jansen M. An in vitro bioassay to determine individual sensitivity to glucocorticoids: induction of FKBP51 mRNA in peripheral blood mononuclear cells. Molecular and Cellular Endocrinology 218 (2004) 49-55
32. Wenger M., Sieber-Ruckstuhl N.S., Muller C., and Reusch C.E. Effect of trilostane on serum concentrations of aldosterone, cortisol, and potassium in dogs with pituitary-dependent hyperadrenocorticism. American Journal of Veterinary Research 65 (2004) 1245-1250
33. Witt A.L., and Neiger R. Adrenocorticotropic hormone levels in dogs with pituitary-dependent hyperadrenocorticism following trilostane therapy. Veterinary Record 154 (2004) 399-400