Preparation of cross-linked carboxymethyl chitosan for repairing sciatic nerve injury in rats

Biotechnology Letters

Volumn 32, Issue 1, 2010, Pages 59-66

  Wang, Gan ^a   Lu, Guangyuan ^a   Ao, Qiang ^a   Gong, Yandao ^a   Zhang, Xiufang ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

Biodegradability; Carboxymethylation; Chitosan; Cross linking; Peripheral nerve regeneration

Indexed keywords

BIODEGRADABILITY; CELL CULTURE; CELL MEMBRANES; DEFECT DENSITY; DEGRADATION; NEURONS; REPAIR; TUBES (COMPONENTS);

CARBODIIMIDE HYDROCHLORIDES; CARBOXYMETHYL CHITOSAN; CARBOXYMETHYLATION; LYSOZYME SOLUTIONS; NERVE REGENERATION; PERIPHERAL NERVE REGENERATION; RAT SCIATIC NERVE; SLOW DEGRADATION;

CHITOSAN;

RATTUS;

EID: 72249096709     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-009-0123-1     Document Type: Article

References (14)

1. Cao W, Cheng M, Ao Q, Gong Y, Zhao N, Zhang X (2005) Physical, mechanical and degradation properties, and Schwann cell affinity of cross-linked chitosan films. J Biomater Sci Polym Ed 16: 791-807.
2. Chamberlain LJ, Yannas IV, Arrizabalaga A, Hsu HP, Norregaard TV, Spector M (1998) Early peripheral nerve healing in collagen and silicone tube implants: myofibroblasts and the cellular response. Biomaterials 15: 1393-1403.
3. Chamberlain LJ, Yannas IV, Hsu HP, Strichartz GR, Spector M (2000) Near-terminus axonal structure and function following rat sciatic nerve regeneration through a collagen-GAG matrix in a ten-millimeter gap. J Neurosci Res 60: 666-677.
4. Chen X, Wang Z, Liu W, Park H (2002) The effect of carboxymethyl chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts. Biomaterials 23: 4609-4614.
5. Heath CA, Rutkowski GE (1998) The development of bioartificial nerve grafts for peripheral nerve regeneration. Trends Biotechnol 16: 163-168.
6. Khor E, Lim LY (2003) Implantable applications of chitin and chitosan. Biomaterials 24: 2339-2349.
7. Kong LJ, Gao Y, Lu GY, Gong YD, Zhao NM, Zhang XF (2006) A study on the bioactivity of chitosan/nano-hydroxyapatite composite scaffolds for bone tissue engineering. Eur Polym J 42: 3171-3179.
8. Lu GY, Kong LJ, Sheng BY, Wang G, Gong YD, Zhang XF (2007) Degradation of covalently cross-linked carboxymethyl chitosan and its potential application for peripheral nerve regeneration. Eur Polym J 43: 3807-3818.
9. Mi F, Tan Y, Liang H, Sung H (2002) In vivo biocompatibility and degradability of a novel injectable chitosan based implant. Biomaterials 23: 181-191.
10. Ragnhild J, Hjerde N, Varum KM (1997) Chemical composition of O-(carboxymethyl) chitins in relation to lysozyme degradation rate. Carbohydr Polym 34: 131-139.
11. Tomihata K, Ikada Y (1997) In vitro and in vivo degradation of films of chitin and its deacetylated derivatives. Biomaterials 18: 567-575.
12. Vord PJV, Matthew HWT, DeSilva SP, Mayton L, Wu B, Wooley PH (2002) Evaluation of the biocompatibility of a chitosan scaffold in mice. J Biomed Mater Res 59: 585-590.
13. Xu X, Yee WC, Hwang PY, Yu H, Wan AC, Gao S, Boon KL, Mao HQ, Leong KW, Wang S (2003) Peripheral nerve regeneration with sustained release of poly(phosphoester) microencapsulated nerve growth factor within nerve guide tubes. Biomaterials 24: 2405-2412.
14. Zhu A, Fang N (2005) Adhesion dynamics, morphology, and organization of 3T3 fibroblast on chitosan and its derivative: the effect of O-carboxymethylation. Biomacromolecules 6: 2607-2614.