Synthesis of 4-substituted 2-(4-methylpiperazino)pyrimidines and quinazoline analogs as serotonin 5-HT2A receptor ligands

Journal of Heterocyclic Chemistry

Volumn 46, Issue 6, 2009, Pages 1259-1265

  Saczewski, Jaroslaw ^a,c   Paluchowska, Aldona ^a,d   Klenc, Jeffrey ^a   Raux, Elizabeth ^a   Barnes, Samuel ^a   Sullivan, Shannon ^a   Duszynska, Beata ^b   Bojarski, Andrzej J ^b   Strekowskia, Lucjan ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c MEDICAL UNIVERSITY OF GDANSK   (Poland)

^d Alanus   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 METHYLPIPERAZINO) 4 (2 BIPHENYL)PYRIMIDINE; 2 (4 METHYLPIPERAZINO) 4 (3 PYRIDYL)PYRIMIDINE; 2 (4 METHYLPIPERAZINO) 4 (9 PHENANTHRYL)PYRIMIDINE; 2 (4 METHYLPIPERAZINO) 4 (PHENYLETHYNYL)PYRIMIDINE; 2 (4 METHYLPIPERAZINO)PYRIMIDINE DERIVATIVE; 4 (1 METHYLINDOL 2 YL) 2 (4 METHYLPIPERAZINO)PYRIMIDINE; 4 (1,3 DIOXANE 2 YL) 2 (4 METHYLPIPERAZINO)PYRIMIDINE; 4 (1,3 DIOXOLANE 2 YL) 2 (4 METHYLPIPERAZINO)PYRIMIDINE; 4 (1,3 DITHIANE 2 YL) 2 (4 METHYLPIPERAZINO)PYRIMIDINE; 4 (1,4 BENZODIOXANE 4 YL) 2 (4 METHYLPIPERAZINO) PYRIMIDINE; 4 (2 METHOXYPHENYL) 2 (4 METHYLPIPERAZINO)PYRIMIDINE; 4 (2,2' BITHIOPHEN 5 YL) 2 (4 METHYLPIPERAZINO) PYRIMIDINE; 4 (2,3 DIMETHOXY 1 NAPHTHYL) 2 (4 METHYLPIPERAZINO) PYRIMIDINE; 4 (3 METHOXYPHENYL) 2 (4 METHYLPIPERAZINO)PYRIMIDINE; 4 (3,4 DIHYDRO 2H PYRAN 6 YL) 2 (4 METHYLPIPERAZINO) PYRIMIDINE; 4 (3,4 METHYLENEDIOXYPHENYL) 2 (4 METHYLPIPERAZINO) PYRIMIDINE; 4 (4 METHOXYPHENYL) 2 (4 METHYLPIPERAZINO)PYRIMIDINE; 4 (SEC BUTYL) 2 (4 METHYLPIPERAZINO)PYRIMIDINE; 4 (TERT BUTYL) 2 (4 METHYLPIPERAZINO)PYRIMIDINE; 4 [(CYCLOHEXEN 1 YL)ETHYNYL] 2 (4 METHYLPIPERAZINO) PYRIMIDINE; 4 BUTYL 2 (4 METHYLPIPERAZINO)PYRIMIDINE; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ADDITION REACTION; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; LIGAND BINDING; OXIDATION; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

EID: 72249093979     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.236     Document Type: Article

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