Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 2, 2010, Pages 448-452

  Torrisi, Caterina ^a   Bisbocci, Monica ^a   Ingenito, Raffaele ^a   Ontoria, Jesus M ^a   Rowley, Michael ^a   Schultz Fademrecht, Carsten ^a   Toniatti, Carlo ^a   Jones, Philip ^a  

^a IRBM   (Italy)

Author keywords

Cancer; Hexahydrobenzonaphthyridinone; PARP

Indexed keywords

MOLECULAR SCAFFOLD; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR;

ARTICLE; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG DISCOVERY; ENZYME INHIBITORS; MICROSOMES, LIVER; NAPHTHYRIDINES; POLY(ADP-RIBOSE) POLYMERASES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 72249092276     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.002     Document Type: Article

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