In vitro and in vivo assessment of matrix type transdermal therapeutic system of labetalol hydrochloride

Current Drug Delivery

Volumn 6, Issue 5, 2009, Pages 511-519

  Mittal, Ashu ^a   Parmar, Shikha ^a   Singh, Brijendra ^b  

^a ITS Paramedical College Pharmacy   (India)

^b ITS Centre for Dental Studies and Research ^*  (India)

Author keywords

Eudragit E PO; Eudragit RL 100; Human cadaver skin; Labetalol hydrochloride; Matrix type; Plasdone S 630 (copovidone); Transdermal

Indexed keywords

EUDRAGIT; LABETALOL; POLYMER; POVIDONE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CADAVER; CHEMICAL INTERACTION; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG MECHANISM; DRUG PENETRATION; DRUG POTENCY; DRUG RELEASE; DRUG STABILITY; ENVIRONMENTAL TEMPERATURE; FILM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHARMACODYNAMICS; PHARMACOLOGICAL PARAMETERS; POLYMERIZATION; PRIORITY JOURNAL; RAT; SCORING SYSTEM; SKIN; SKIN IRRITATION; SKIN PERMEABILITY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; ELASTICITY; HUMANS; LABETALOL; MODELS, BIOLOGICAL; PERMEABILITY; POLYMERS; RATS; RATS, WISTAR; SKIN; SKIN IRRITANCY TESTS; SOLUBILITY; TENSILE STRENGTH; WATER;

EID: 72149114574     PISSN: 15672018     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720109789941614     Document Type: Article

References (26)

1. Goa, K.L.; Benfield, P.; Sorkin, E.M. Labetalol, A reappraisal of its pharmacology, pharmacokinetics and therapeutic use in hypertension and ischaemic heart disease. Drugs., 1989, 37(5), 583-627
2. Donneily, R.; Macphe, G.J.A. Review of pharmacology. Clin. Pharmacokinet., 1991, 21, 95-109.
3. Chien, Y.W. Transdermal therapeutic systems. In: Controlled Drug Delivery Fundamentals & Applications, 2nd ed.; Robinson J.R., Lee V.H.L., Eds.; Marcel Dekker: New York, NY, 1987, pp. 524-552.
4. Kaith, A.D. Polymer matrix considerations for transdermal devices. Drug Deliv. Ind. Pharm., 1983, 9, 605-621.
5. Pai, R. M.; Desai, M. S.; Babtiwale, A.D.; Shrivastava, R. Adhesive matrix type transdrmal drug delivery system for nitroglycerin. Drug Deliv. Ind. Pharm., 1994, 20, 1905-1909. (Pubitemid 24202687)
6. Singh, J.; Tripathi, K.P.; Sakia, T.R. Effect of penetration enhancers on the in vitro transport of ephedrine through rat skin and human epidermis from matrix based transdermal formulation. Drug Deliv. Ind. Pharm., 1993, 19, 1623-1628.
7. Dnyanesh, N.T.; Pradeep, R.V. Acrylate-Based Transdermal Therapeutic System of Nitrendipine. Drug Deliv. Ind. Pharm., 2003, 29(1), 71-78. (Pubitemid 36205883)
8. Aqil, M.; Zafar, S.; Ali, A.; Ahmad, S. Transdermal drug delivery of labetalol hydrochloride: system development, in vitro; ex vivo and in vivo characterization. Curr. Drug Deliv., 2005, 2(2), 125-131. (Pubitemid 40488622)
9. Arora, P.; Mukherjee, B. Design, development, physicochemical, and in vitro and in vivo evaluation of transdermal patches containg diclofenac diethylammonium salt. J. Pharm. Sci., 2002, 91(9), 2076-2089.
10. Udhumansha, U.; Reddy, M.V.S.; Kumaresan, R.; Ahmad, F.J.; Khar, R.K. Transdermal therapeutic system of carvedilol: effect of hydrophilic and hydrophobic matrix on in vitro and in vivo characteristics. AAPS Pharm. Sci. Tech., 2007, 8, E1-E8.
11. Costa, P.; Lobo, S. Modeling and comparison of dissolution profiles. Eur. J. Pharm. Sci., 2001, 13(2), 123-133.
12. Singh, B.; Chauhan, G.S.; Sharma, D.K.; Kant, A.; Gupta, I.; Chauhan, N. The release dynamics of model drugs from the psyllium and N- hydroxymethyacrylamide based hydrogels. Int. J. Pharm., 2006, 325,15-25. (Pubitemid 44604439)
13. Kligman, A.M.; Christopers, E. Preparation of isolated sheets of stratum corneum. Arch. Dermatol., 1963, 88, 702-705.
14. Haigh, J.M.; Smith, E.W. The selection and use of natural and synthetic membranes for in vitro diffusion experiments. Eur. J. Pharm. Sci., 1994, 2, 311-330.
15. Sonkro, S.; Purwo, Y.; Becket, G.; Rades, T. Investigation of new born pig skin as an invitro animal model for transdermal drug delivery. STP Pharma. Sci., 2003, 13, 33-139. (Pubitemid 36373035)
16. Kakkar, A.P.; Gupta, A. Gelatin based transdermal therapeutic system. Indian Drugs, 1992, 29, 308-312.
17. Vaddi, H.K.; Ho, P.C.; Chan, S. Y. Terpenes in propylene glycol as skin penetration enhnacers: permeation and partition of haloperidol, fourier transform infrared spectroscopy, and differential scanning calorimetry. J Pharm. Sci., 2002, 91(7), 1639-1651.
18. Ghosh, M. N. Fundamentals of Experimental Pharmacology. Hilton and company: Kolkata, 2005, pp. 190-197
19. Muir, K.; Hidalgo, I. High Performance liquid chromatography method for determination of labetalol in plasma using UV detection. J. Chromatogr., 1984, 305, 222-227. (Pubitemid 14185668)
20. Dai, S.; McNeil, J. H. Fructose induced hypertension in rats is concentration and duration dependent. J. Pharm. Tox. Methods, 1999, 33, 101-107.
21. Hermansky, S. J.; Leung, H.W. Cutaneous toxicity studies with methoxy polyethylene glycol-350 (MPEG-350) in rats and rabbits. Food Chem. Toxicol., 1997, 35, 1031-1039.
22. Samuelov, Y.; Donbrow, M.; Friedman, M. Sustained release of drugs from ethylcellulose-polyethylene glycol films and kinetics of drug release. J. Pharm. Sci., 1979, 68, 325-329. (Pubitemid 9139725)
23. Ozyazici, M.; Gokce, E. H.; Ertan, G. Release and diffusional modeling of metronidazole lipid matrices. Eur. J. Pharm. Biopharm., 2006, 63, 331-339.
24. Roa, P. R.; Rama, K. S.; Diwan, P. V. Drug release kinetics from polymeric films containing propranolol hydrochloride for transdermal use. Pharm. Deliv. Tech., 2000, 5, 465-472.
25. Roa, P. R.; Diwan, P. V. Formulation and in vitro evaluation of polymeric films of diltiazem hydrochloride and indomethacin for transdermal administration. Drug Deliv. Ind. Pharm., 1998, 24 , 327-336.
26. Draize, J. H.; Woodward, G.; Calvery, H. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membrane. J. Pharmacol. Exp. Ther., 1994, 82, 377-390.