Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: Convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases

Journal of Biological Chemistry

Volumn 284, Issue 51, 2009, Pages 35514-35523

  Heyes, Derren J ^a   Levy, Colin ^a   Lafite, Pierre ^a   Roberts, Ian S ^a   Goldrick, Marie ^a   Stachulski, Andrew V ^b   Rossington, Steven B ^b   Stanford, Deborah ^a   Rigby, Stephen E ^a   Scrutton, Nigel S ^a   Leys, David ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CONVERGENT EVOLUTION; EPR MEASUREMENTS; HYDROXYL GROUPS; ISOTHERMAL CALORIMETRY; KEY REACTIONS; LIGAND-FREE; LIPOPOLYSACCHARIDES; MONOPHOSPHATES; N-ACETYLNEURAMINIC ACID; REACTION CATALYZED; STRUCTURE-BASED; SYNTHASES; SYNTHETASES; TERNARY COMPLEX;

ACIDS; BINDING SITES; BIOCHEMISTRY; CATALYSTS; CHEMICAL ACTIVATION; ENZYMES; ESCHERICHIA COLI; FLUORINE CONTAINING POLYMERS; LIGANDS; MANGANESE; MANGANESE COMPOUNDS; METAL IONS; NANOTECHNOLOGY; SUBSTRATES; SUGAR (SUCROSE);

SUGARS;

CMP 2 KETO 3 DEOXYMANNO OCTULONIC ACID SYNTHETASE; DNA POLYMERASE; RNA POLYMERASE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; ESCHERICHIA COLI; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION;

CRYSTALLOGRAPHY, X-RAY; CYTIDINE TRIPHOSPHATE; DNA-DIRECTED DNA POLYMERASE; DNA-DIRECTED RNA POLYMERASES; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; NUCLEOTIDYLTRANSFERASES; PROTEIN STRUCTURE, TERTIARY; STRUCTURAL HOMOLOGY, PROTEIN;

ESCHERICHIA COLI;

EID: 72149113859     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.056630     Document Type: Article

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