메뉴 건너뛰기




Volumn 31, Issue 3, 2010, Pages 189-201

Mechanisms and control of protein translation in the kidney

Author keywords

Diabetic nephropathy; MicroRNA; MTOR; Nephritis; Nephropathy; Polycystic kidney disease; Protein synthesis; Renal cancer; Translational control

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; RNA;

EID: 72149112785     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000268954     Document Type: Review
Times cited : (8)

References (113)
  • 1
    • 34547938506 scopus 로고    scopus 로고
    • MicroRNAs: A safeguard against turmoil?
    • Leung AK, Sharp PA: MicroRNAs: A safeguard against turmoil? Cell 2007; 130: 581-585.
    • (2007) Cell , vol.130 , pp. 581-585
    • Leung, A.K.1    Sharp, P.A.2
  • 3
    • 60149091189 scopus 로고    scopus 로고
    • Regulation of translation initiation in eukaryotes: Mechanisms and biological targets
    • Sonenberg N, Hinnebusch AG: Regulation of translation initiation in eukaryotes: Mechanisms and biological targets. Cell 2009; 136: 731-745.
    • (2009) Cell , vol.136 , pp. 731-745
    • Sonenberg, N.1    Hinnebusch, A.G.2
  • 6
    • 0024414469 scopus 로고
    • Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs
    • Kozak M: Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs. Mol Cell Biol 1989; 9: 5134-5142.
    • (1989) Mol Cell Biol , vol.9 , pp. 5134-5142
    • Kozak, M.1
  • 7
    • 0023665902 scopus 로고
    • An analysis of 5-noncoding sequences from 699 vertebrate messenger RNAs
    • Kozak M: An analysis of 5-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res 1987; 15: 8125-8148.
    • (1987) Nucleic Acids Res , vol.15 , pp. 8125-8148
    • Kozak, M.1
  • 9
    • 57649148808 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta is a novel regulator of high glucose- and high insulin-induced extracellular matrix protein synthesis in renal proximal tubular epithelial cells
    • Mariappan MM, Shetty M, Sataranatarajan K, Choudhury GG, Kasinath BS: Glycogen synthase kinase 3beta is a novel regulator of high glucose- and high insulin-induced extracellular matrix protein synthesis in renal proximal tubular epithelial cells. J Biol Chem 2008; 283: 30566-30575.
    • (2008) J Biol Chem , vol.283 , pp. 30566-30575
    • Mariappan, M.M.1    Shetty, M.2    Sataranatarajan, K.3    Choudhury, G.G.4    Kasinath, B.S.5
  • 10
    • 2342633872 scopus 로고    scopus 로고
    • Cellular internal ribosome entry segments: Structures, transacting factors and regulation of gene expression
    • Stoneley M, Willis AE: Cellular internal ribosome entry segments: Structures, transacting factors and regulation of gene expression. Oncogene 2004; 23: 3200-3207.
    • (2004) Oncogene , vol.23 , pp. 3200-3207
    • Stoneley, M.1    Willis, A.E.2
  • 11
    • 0034459468 scopus 로고    scopus 로고
    • Upstream open reading frames as regulators of mRNA translation
    • Morris DR, Geballe AP: Upstream open reading frames as regulators of mRNA translation. Mol Cell Biol 2000; 20: 8635-8642.
    • (2000) Mol Cell Biol , vol.20 , pp. 8635-8642
    • Morris, D.R.1    Geballe, A.P.2
  • 12
    • 33645875031 scopus 로고    scopus 로고
    • Downstream control of upstream open reading frames
    • Sachs MS, Geballe AP: Downstream control of upstream open reading frames. Genes Dev 2006; 20: 915-921.
    • (2006) Genes Dev , vol.20 , pp. 915-921
    • Sachs, M.S.1    Geballe, A.P.2
  • 13
    • 17144424622 scopus 로고    scopus 로고
    • Translational control in stress and apoptosis
    • Holcik M, Sonenberg N: Translational control in stress and apoptosis. Nat Rev Mol Cell Biol 2005; 6: 318-327.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 318-327
    • Holcik, M.1    Sonenberg, N.2
  • 14
    • 32544446451 scopus 로고    scopus 로고
    • Coping with stress: Eif2 kinases and translational control
    • Wek RC, Jiang HY, Anthony TG: Coping with stress: Eif2 kinases and translational control. Biochem Soc Trans 2006; 34: 7-11.
    • (2006) Biochem Soc Trans , vol.34 , pp. 7-11
    • Wek, R.C.1    Jiang, H.Y.2    Anthony, T.G.3
  • 15
    • 38849172516 scopus 로고    scopus 로고
    • Re-programming of translation following cell stress allows ires-mediated translation to predominate
    • Spriggs KA, Stoneley M, Bushell M, Willis AE: Re-programming of translation following cell stress allows ires-mediated translation to predominate. Biol Cell 2008; 100: 27-38.
    • (2008) Biol Cell , vol.100 , pp. 27-38
    • Spriggs, K.A.1    Stoneley, M.2    Bushell, M.3    Willis, A.E.4
  • 16
    • 41749089797 scopus 로고    scopus 로고
    • Reprogramming mRNA translation during stress
    • Yamasaki S, Anderson P: Reprogramming mRNA translation during stress. Curr Opin Cell Biol 2008; 20: 222-226.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 222-226
    • Yamasaki, S.1    Anderson, P.2
  • 18
    • 0037189303 scopus 로고    scopus 로고
    • Regulation of hypoxic death in C. elegans by the insulin/ IgF receptor homolog daf-2
    • Scott BA, Avidan MS, Crowder CM: Regulation of hypoxic death in C. elegans by the insulin/ IgF receptor homolog daf-2. Science 2002; 296: 2388-2391.
    • (2002) Science , vol.296 , pp. 2388-2391
    • Scott, B.A.1    Avidan, M.S.2    Crowder, C.M.3
  • 20
    • 12144264839 scopus 로고    scopus 로고
    • Transcriptional targets of daf-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress
    • Lamitina ST, Strange K: Transcriptional targets of daf-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress. Am J Physiol Cell Physiol 2005; 288: C467-C474.
    • (2005) Am J Physiol Cell Physiol , vol.288
    • Lamitina, S.T.1    Strange, K.2
  • 21
    • 33751198463 scopus 로고    scopus 로고
    • Increased rheb-tor signaling enhances sensitivity of the whole organism to oxidative stress
    • Patel PH, Tamanoi F: Increased rheb-tor signaling enhances sensitivity of the whole organism to oxidative stress. J Cell Sci 2006; 119: 4285-4292.
    • (2006) J Cell Sci , vol.119 , pp. 4285-4292
    • Patel, P.H.1    Tamanoi, F.2
  • 23
    • 34848837296 scopus 로고    scopus 로고
    • MiRNAs get an early start on translational silencing
    • Meister G: MiRNAs get an early start on translational silencing. Cell 2007; 131: 25-28.
    • (2007) Cell , vol.131 , pp. 25-28
    • Meister, G.1
  • 24
    • 33748928159 scopus 로고    scopus 로고
    • The diverse functions of microRNAs in animal development and disease
    • Kloosterman WP, Plasterk RH: The diverse functions of microRNAs in animal development and disease. Dev Cell 2006; 11: 441-450.
    • (2006) Dev Cell , vol.11 , pp. 441-450
    • Kloosterman, W.P.1    Plasterk, R.H.2
  • 25
    • 61849137222 scopus 로고    scopus 로고
    • Many roads to maturity: Micro- RNA biogenesis pathways and their regulation
    • Winter J, Jung S, Keller S, Gregory RI, Diederichs S: Many roads to maturity: Micro- RNA biogenesis pathways and their regulation. Nat Cell Biol 2009; 11: 228-234.
    • (2009) Nat Cell Biol , vol.11 , pp. 228-234
    • Winter, J.1    Jung, S.2    Keller, S.3    Gregory, R.I.4    Diederichs, S.5
  • 26
    • 34249282243 scopus 로고    scopus 로고
    • Drosophila mir2 induces pseudo-polysomes and inhibits translation initiation
    • Thermann R, Hentze MW: Drosophila mir2 induces pseudo-polysomes and inhibits translation initiation. Nature 2007; 447: 875-878.
    • (2007) Nature , vol.447 , pp. 875-878
    • Thermann, R.1    Hentze, M.W.2
  • 28
  • 31
    • 33847024296 scopus 로고    scopus 로고
    • High glucose, high insulin, and their combination rapidly induce laminin-beta1 synthesis by regulation of mRNA translation in renal epithelial cells
    • Mariappan MM, Feliers D, Mummidi S, Choudhury GG, Kasinath BS: High glucose, high insulin, and their combination rapidly induce laminin-beta1 synthesis by regulation of mRNA translation in renal epithelial cells. Diabetes 2007; 56: 476-485.
    • (2007) Diabetes , vol.56 , pp. 476-485
    • Mariappan, M.M.1    Feliers, D.2    Mummidi, S.3    Choudhury, G.G.4    Kasinath, B.S.5
  • 33
    • 55249083264 scopus 로고    scopus 로고
    • Role of TSC-mTOR pathway in diabetic nephropathy
    • Inoki K: Role of TSC-mTOR pathway in diabetic nephropathy. Diabetes Res Clin Pract 2008; 82(suppl 1):S59-S62.
    • (2008) Diabetes Res Clin Pract , vol.82 , Issue.SUPPL.1
    • Inoki, K.1
  • 34
    • 55249118568 scopus 로고    scopus 로고
    • Role of reactive oxygen species in the pathogenesis of diabetic nephropathy
    • Ha H, Hwang IA, Park JH, Lee HB: Role of reactive oxygen species in the pathogenesis of diabetic nephropathy. Diabetes Res Clin Pract 2008; 82(suppl 1):S42-S45.
    • (2008) Diabetes Res Clin Pract , vol.82 , Issue.SUPPL.1
    • Ha, H.1    Hwang, I.A.2    Park, J.H.3    Lee, H.B.4
  • 36
    • 63349088070 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in the kidney as a novel mediator of kidney injury
    • Inagi R: Endoplasmic reticulum stress in the kidney as a novel mediator of kidney injury. Nephron Exp Nephrol 2009; 112:e1-e9.
    • (2009) Nephron Exp Nephrol , vol.112
    • Inagi, R.1
  • 38
    • 34748880045 scopus 로고    scopus 로고
    • Rapamycin prevents early steps of the development of diabetic nephropathy in rats
    • Yang Y, Wang J, Qin L, Shou Z, Zhao J, Wang H, Chen Y, Chen J: Rapamycin prevents early steps of the development of diabetic nephropathy in rats. Am J Nephrol 2007; 27: 495-502.
    • (2007) Am J Nephrol , vol.27 , pp. 495-502
    • Yang, Y.1    Wang, J.2    Qin, L.3    Shou, Z.4    Zhao, J.5    Wang, H.6    Chen, Y.7    Chen, J.8
  • 39
    • 55449116735 scopus 로고    scopus 로고
    • Renal activity of akt kinase in experimental type 1 diabetes
    • Zdychova J, Vesela J, Kazdova L, Komers R: Renal activity of akt kinase in experimental type 1 diabetes. Physiol Res 2007; 57: 709-715.
    • (2007) Physiol Res , vol.57 , pp. 709-715
    • Zdychova, J.1    Vesela, J.2    Kazdova, L.3    Komers, R.4
  • 42
    • 0034925040 scopus 로고    scopus 로고
    • A link between diabetes and atherosclerosis: Glucose regulates expression of cd36 at the level of translation
    • Griffin E, Re A, Hamel N, Fu C, Bush H, Mc- Caffrey T, Asch AS: A link between diabetes and atherosclerosis: glucose regulates expression of cd36 at the level of translation. Nat Med 2001; 7: 840-846.
    • (2001) Nat Med , vol.7 , pp. 840-846
    • Griffin, E.1    Re, A.2    Hamel, N.3    Fu, C.4    Bush, H.5    Mc- Caffrey, T.6    Asch, A.S.7
  • 45
    • 63049117088 scopus 로고    scopus 로고
    • Interactions between advanced glycation end-products (age) and their receptors in the development and progression of diabetic nephropathy: Are these receptors valid therapeutic targets
    • Sourris KC, Forbes JM: Interactions between advanced glycation end-products (age) and their receptors in the development and progression of diabetic nephropathy: are these receptors valid therapeutic targets. Curr Drug Targets 2009; 10: 42-50.
    • (2009) Curr Drug Targets , vol.10 , pp. 42-50
    • Sourris, K.C.1    Forbes, J.M.2
  • 46
    • 0037326359 scopus 로고    scopus 로고
    • When translation meets metabolism: Multiple links to diabetes
    • Shi Y, Taylor SI, Tan SL, Sonenberg N: When translation meets metabolism: multiple links to diabetes. Endocr Rev 2003; 24: 91-101.
    • (2003) Endocr Rev , vol.24 , pp. 91-101
    • Shi, Y.1    Taylor, S.I.2    Tan, S.L.3    Sonenberg, N.4
  • 48
    • 31644445070 scopus 로고    scopus 로고
    • P27(kip1) knockout mice are protected from diabetic nephropathy: Evidence for p27(kip1) haplotype insufficiency
    • Wolf G, Schanze A, Stahl RA, Shankland SJ, Amann K: P27(kip1) knockout mice are protected from diabetic nephropathy: evidence for p27(kip1) haplotype insufficiency. Kidney Int 2005; 68: 1583-1589.
    • (2005) Kidney Int , vol.68 , pp. 1583-1589
    • Wolf, G.1    Schanze, A.2    Stahl, R.A.3    Shankland, S.J.4    Amann, K.5
  • 50
    • 33750155593 scopus 로고    scopus 로고
    • Insulin and aminoacid regulation of mTOR signaling and kinase activity through the Rheb GTPase
    • Avruch J, Hara K, Lin Y, Liu M, Long X, Ortiz- Vega S, Yonezawa K: Insulin and aminoacid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene 2006; 25: 6361-6372.
    • (2006) Oncogene , vol.25 , pp. 6361-6372
    • Avruch, J.1    Hara, K.2    Lin, Y.3    Liu, M.4    Long, X.5    Ortiz- Vega, S.6    Yonezawa, K.7
  • 53
    • 67649616517 scopus 로고    scopus 로고
    • Long-term treatment of sirolimus but not cyclosporine ameliorates diabetic nephropathy in the rat
    • Wittmann S, Daniel C, Stief A, Vogelbacher R, Amann K, Hugo C: Long-term treatment of sirolimus but not cyclosporine ameliorates diabetic nephropathy in the rat. Transplantation 2009; 87: 1290-1299.
    • (2009) Transplantation , vol.87 , pp. 1290-1299
    • Wittmann, S.1    Daniel, C.2    Stief, A.3    Vogelbacher, R.4    Amann, K.5    Hugo, C.6
  • 54
    • 57349186092 scopus 로고    scopus 로고
    • MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy
    • Wang Q, Wang Y, Minto AW, Wang J, Shi Q, Li X, Quigg RJ: MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J 2008; 22: 4126-4135.
    • (2008) FASEB J , vol.22 , pp. 4126-4135
    • Wang, Q.1    Wang, Y.2    Minto, A.W.3    Wang, J.4    Shi, Q.5    Li, X.6    Quigg, R.J.7
  • 55
    • 33847682663 scopus 로고    scopus 로고
    • MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of e-box repressors
    • Kato M, Zhang J, Wang M, Lanting L, Yuan H, Rossi JJ, Natarajan R: MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of e-box repressors. Proc Natl Acad Sci USA 2007; 104: 3432-3437.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 3432-3437
    • Kato, M.1    Zhang, J.2    Wang, M.3    Lanting, L.4    Yuan, H.5    Rossi, J.J.6    Natarajan, R.7
  • 56
    • 0030828898 scopus 로고    scopus 로고
    • Diabetes induces changes in glomerular development and laminin-beta 2 (s-laminin) expression
    • Abrass CK, Spicer D, Berfield AK, St John PL, Abrahamson DR: Diabetes induces changes in glomerular development and laminin-beta 2 (s-laminin) expression. Am J Pathol 1997; 151: 1131-1140.
    • (1997) Am J Pathol , vol.151 , pp. 1131-1140
    • Abrass, C.K.1    Spicer, D.2    Berfield, A.K.3    St John, P.L.4    Abrahamson, D.R.5
  • 57
    • 75149193959 scopus 로고    scopus 로고
    • Reductions in laminin {beta}2 mRNA translation are responsible for impaired IgFbp-5-mediated mesangial cell migration in the presence of high glucose
    • in press
    • Schaeffer V, Hansen KM, Morris DR, Abrass CK: Reductions in laminin {beta}2 mRNA translation are responsible for impaired IgFbp-5-mediated mesangial cell migration in the presence of high glucose. Am J Physiol Renal Physiol 2009;in press.
    • (2009) Am J Physiol Renal Physiol
    • Schaeffer, V.1    Hansen, K.M.2    Morris, D.R.3    Abrass, C.K.4
  • 58
    • 4744349621 scopus 로고
    • An unusual congenital and familial congenital malformative combination involving the eye and kidney
    • Pierson M, Cordier J, Hervouuet F, Rauber G: An unusual congenital and familial congenital malformative combination involving the eye and kidney. J Genet Hum 1963; 12: 184-213.
    • (1963) J Genet Hum , vol.12 , pp. 184-213
    • Pierson, M.1    Cordier, J.2    Hervouuet, F.3    Rauber, G.4
  • 61
    • 24344432695 scopus 로고    scopus 로고
    • Demonstration of two novel lamb2 mutations in the original Pierson syndrome family reported 42 years ago
    • Zenker M, Pierson M, Jonveaux P, Reis A: Demonstration of two novel lamb2 mutations in the original Pierson syndrome family reported 42 years ago. Am J Med Genet A 2005; 138: 73-74.
    • (2005) Am J Med Genet A , vol.138 , pp. 73-74
    • Zenker, M.1    Pierson, M.2    Jonveaux, P.3    Reis, A.4
  • 62
    • 33746730496 scopus 로고    scopus 로고
    • Proteinuria precedes podocyte abnormalities in lamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier
    • Jarad G, Cunningham J, Shaw AS, Miner JH: Proteinuria precedes podocyte abnormalities in lamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier. J Clin Invest 2006; 116: 2272-2279.
    • (2006) J Clin Invest , vol.116 , pp. 2272-2279
    • Jarad, G.1    Cunningham, J.2    Shaw, A.S.3    Miner, J.H.4
  • 63
    • 70349337337 scopus 로고    scopus 로고
    • MicroRNAs and their role in progressive kidney diseases
    • Kato M, Arce L, Natarajan R: MicroRNAs and their role in progressive kidney diseases. Clin J Am Soc Nephrol 2009; 4: 1255-1266.
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 1255-1266
    • Kato, M.1    Arce, L.2    Natarajan, R.3
  • 65
    • 0024272942 scopus 로고
    • Phenotypic expression of collagen types in mesangial matrix of diabetic and nondiabetic rats
    • Abrass CK, Peterson CV, Raugi GJ: Phenotypic expression of collagen types in mesangial matrix of diabetic and nondiabetic rats. Diabetes 1988; 37: 1695-1702.
    • (1988) Diabetes , vol.37 , pp. 1695-1702
    • Abrass, C.K.1    Peterson, C.V.2    Raugi, G.J.3
  • 66
    • 0028022745 scopus 로고
    • Insulin induces a change in extracellular matrix glycoproteins synthesized by rat mesangial cells in culture
    • Abrass CK, Spicer D, Raugi GJ: Insulin induces a change in extracellular matrix glycoproteins synthesized by rat mesangial cells in culture. Kidney Int 1994; 46: 613-620.
    • (1994) Kidney Int , vol.46 , pp. 613-620
    • Abrass, C.K.1    Spicer, D.2    Raugi, G.J.3
  • 67
    • 0029012090 scopus 로고
    • Diabetic nephropathy: Mechanisms of mesangial matrix expansion
    • Abrass CK: Diabetic nephropathy: mechanisms of mesangial matrix expansion. West J Med 1995; 162: 318-321.
    • (1995) West J Med , vol.162 , pp. 318-321
    • Abrass, C.K.1
  • 68
    • 0028954959 scopus 로고
    • Induction of nodular sclerosis by insulin in rat mesangial cells in vitro: Studies of collagen
    • Abrass CK, Spicer D, Raugi GJ: Induction of nodular sclerosis by insulin in rat mesangial cells in vitro: studies of collagen. Kidney Int 1995; 47: 25-37.
    • (1995) Kidney Int , vol.47 , pp. 25-37
    • Abrass, C.K.1    Spicer, D.2    Raugi, G.J.3
  • 69
    • 42049083539 scopus 로고    scopus 로고
    • Regulation of mRNA translation during cellular division
    • Sivan G, Elroy-Stein O: Regulation of mRNA translation during cellular division. Cell Cycle 2008; 7: 741-744.
    • (2008) Cell Cycle , vol.7 , pp. 741-744
    • Sivan, G.1    Elroy-Stein, O.2
  • 70
    • 33845309430 scopus 로고    scopus 로고
    • Activation of the mTOR signaling pathway in renal clear cell carcinoma
    • Robb VA, Karbowniczek M, Klein-Szanto AJ, Henske EP: Activation of the mTOR signaling pathway in renal clear cell carcinoma. J Urol 2007; 177: 346-352.
    • (2007) J Urol , vol.177 , pp. 346-352
    • Robb, V.A.1    Karbowniczek, M.2    Klein-Szanto, A.J.3    Henske, E.P.4
  • 71
    • 65349132693 scopus 로고    scopus 로고
    • Emt, the cytoskeleton, and cancer cell invasion
    • Yilmaz M, Christofori G: Emt, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 2009; 28: 15-33.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 15-33
    • Yilmaz, M.1    Christofori, G.2
  • 72
    • 0033006919 scopus 로고    scopus 로고
    • Eif4e activity is regulated at multiple levels
    • Raught B, Gingras AC: Eif4e activity is regulated at multiple levels. Int J Biochem Cell Biol 1999; 31: 43-57.
    • (1999) Int J Biochem Cell Biol , vol.31 , pp. 43-57
    • Raught, B.1    Gingras, A.C.2
  • 73
    • 0035012605 scopus 로고    scopus 로고
    • Her2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL: Her2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001; 21: 3995-4004.
    • (2001) Mol Cell Biol , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 74
    • 33845235464 scopus 로고    scopus 로고
    • IL-1beta induces VEGF, independently of PGE2 induction, mainly through the PI3-K/mTOR pathway in renal mesangial cells
    • Sola-Villa D, Camacho M, Sola R, Soler M, Diaz JM, Vila L: IL-1beta induces VEGF, independently of PGE2 induction, mainly through the PI3-K/mTOR pathway in renal mesangial cells. Kidney Int 2006; 70: 1935-1941.
    • (2006) Kidney Int , vol.70 , pp. 1935-1941
    • Sola-Villa, D.1    Camacho, M.2    Sola, R.3    Soler, M.4    Diaz, J.M.5    Vila, L.6
  • 75
    • 65949091346 scopus 로고    scopus 로고
    • Targeting mTOR in renal cell carcinoma
    • Hudes GR: Targeting mTOR in renal cell carcinoma. Cancer 2009; 115: 2313-2320.
    • (2009) Cancer , vol.115 , pp. 2313-2320
    • Hudes, G.R.1
  • 76
    • 42349113247 scopus 로고    scopus 로고
    • A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis
    • Shor B, Zhang WG, Toral-Barza L, Lucas J, Abraham RT, Gibbons JJ, Yu K: A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis. Cancer Res 2008; 68: 2934-2943.
    • (2008) Cancer Res , vol.68 , pp. 2934-2943
    • Shor, B.1    Zhang, W.G.2    Toral-Barza, L.3    Lucas, J.4    Abraham, R.T.5    Gibbons, J.J.6    Yu, K.7
  • 77
    • 51649115883 scopus 로고    scopus 로고
    • Statin-dependent suppression of the akt/ mammalian target of rapamycin signaling cascade and programmed cell death 4 upregulation in renal cell carcinoma
    • Woodard J, Sassano A, Hay N, Platanias LC: Statin-dependent suppression of the akt/ mammalian target of rapamycin signaling cascade and programmed cell death 4 upregulation in renal cell carcinoma. Clin Cancer Res 2008; 14: 4640-4649.
    • (2008) Clin Cancer Res , vol.14 , pp. 4640-4649
    • Woodard, J.1    Sassano, A.2    Hay, N.3    Platanias, L.C.4
  • 79
    • 0032987092 scopus 로고    scopus 로고
    • Cadherins in renal cell carcinoma
    • Heicappell R: Cadherins in renal cell carcinoma. Anticancer Res 1999; 19: 1501-1504.
    • (1999) Anticancer Res , vol.19 , pp. 1501-1504
    • Heicappell, R.1
  • 80
    • 1042267263 scopus 로고    scopus 로고
    • Cell adhesion and signalling by cadherins and Ig-cams in cancer
    • Cavallaro U, Christofori G: Cell adhesion and signalling by cadherins and Ig-cams in cancer. Nat Rev Cancer 2004; 4: 118-132.
    • (2004) Nat Rev Cancer , vol.4 , pp. 118-132
    • Cavallaro, U.1    Christofori, G.2
  • 82
    • 2942534582 scopus 로고    scopus 로고
    • Polycystic kidney disease: New understanding in the pathogenesis
    • Wilson PD: Polycystic kidney disease: new understanding in the pathogenesis. Int J Biochem Cell Biol 2004; 36: 1868-1873.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 1868-1873
    • Wilson, P.D.1
  • 85
    • 68949207750 scopus 로고    scopus 로고
    • Inhibition of PKHD1 may cause S-phase entry via mTOR signaling pathway
    • Zheng R, Wang L, Fan J, Zhou Q: Inhibition of PKHD1 may cause S-phase entry via mTOR signaling pathway. Cell Biol Int 2009; 33: 926-933.
    • (2009) Cell Biol Int , vol.33 , pp. 926-933
    • Zheng, R.1    Wang, L.2    Fan, J.3    Zhou, Q.4
  • 86
    • 18744380752 scopus 로고    scopus 로고
    • Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease
    • Tao Y, Kim J, Schrier RW, Edelstein CL: Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease. J Am Soc Nephrol 2005; 16: 46-51.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 46-51
    • Tao, Y.1    Kim, J.2    Schrier, R.W.3    Edelstein, C.L.4
  • 87
    • 33644859253 scopus 로고    scopus 로고
    • Inhibition of mTOR with sirolimus slows disease progression in han:Sprd rats with autosomal dominant polycystic kidney disease (ADPKD)
    • Wahl PR, Serra AL, Le Hir M, Molle KD, Hall MN, Wuthrich RP: Inhibition of mTOR with sirolimus slows disease progression in han:Sprd rats with autosomal dominant polycystic kidney disease (ADPKD). Nephrol Dial Transplant 2006; 21: 598-604.
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 598-604
    • Wahl, P.R.1    Serra, A.L.2    Le Hir, M.3    Molle, K.D.4    Hall, M.N.5    Wuthrich, R.P.6
  • 88
    • 67651087241 scopus 로고    scopus 로고
    • Longterm rapamycin therapy in the han:Sprd rat model of polycystic kidney disease (PKD)
    • Zafar I, Belibi FA, He Z, Edelstein CL: Longterm rapamycin therapy in the han:Sprd rat model of polycystic kidney disease (PKD). Nephrol Dial Transplant 2009; 24: 2349-2353.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 2349-2353
    • Zafar, I.1    Belibi, F.A.2    He, Z.3    Edelstein, C.L.4
  • 89
    • 51749085397 scopus 로고    scopus 로고
    • Polycystin-2 down-regulates cell proliferation via promoting perk-dependent phosphorylation of eif2alpha
    • Liang G, Yang J, Wang Z, Li Q, Tang Y, Chen XZ: Polycystin-2 down-regulates cell proliferation via promoting perk-dependent phosphorylation of eif2alpha. Hum Mol Genet 2008; 17: 3254-3262.
    • (2008) Hum Mol Genet , vol.17 , pp. 3254-3262
    • Liang, G.1    Yang, J.2    Wang, Z.3    Li, Q.4    Tang, Y.5    Chen, X.Z.6
  • 90
    • 55849085074 scopus 로고    scopus 로고
    • Micro- RNA15a modulates expression of the cellcycle regulator CDC25a and affects hepatic cystogenesis in a rat model of polycystic kidney disease
    • Lee SO, Masyuk T, Splinter P, Banales JM, Masyuk A, Stroope A, Larusso N: Micro- RNA15a modulates expression of the cellcycle regulator CDC25a and affects hepatic cystogenesis in a rat model of polycystic kidney disease. J Clin Invest 2008; 118: 3714-3724.
    • (2008) J Clin Invest , vol.118 , pp. 3714-3724
    • Lee, S.O.1    Masyuk, T.2    Splinter, P.3    Banales, J.M.4    Masyuk, A.5    Stroope, A.6    Larusso, N.7
  • 91
    • 60749100351 scopus 로고    scopus 로고
    • Microarraybased approach identifies microRNAs and their target functional patterns in polycystic kidney disease
    • Pandey P, Brors B, Srivastava PK, Bott A, Boehn SN, Groene HJ, Gretz N: Microarraybased approach identifies microRNAs and their target functional patterns in polycystic kidney disease. BMC Genomics 2008; 9: 624.
    • (2008) BMC Genomics , vol.9 , pp. 624
    • Pandey, P.1    Brors, B.2    Srivastava, P.K.3    Bott, A.4    Boehn, S.N.5    Groene, H.J.6    Gretz, N.7
  • 95
    • 23644441147 scopus 로고    scopus 로고
    • Stress proteins in glomerular epithelial cell injury
    • Bijian K, Cybulsky AV: Stress proteins in glomerular epithelial cell injury. Contrib Nephrol. Basel, Karger, 2005, vol 148, pp 8- 20.
    • (2005) Contrib Nephrol. Basel, Karger , vol.148 , pp. 8-20
    • Bijian, K.1    Cybulsky, A.V.2
  • 96
    • 21644458029 scopus 로고    scopus 로고
    • Role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injury
    • Cybulsky AV, Takano T, Papillon J, Bijian K: Role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injury. J Biol Chem 2005; 280: 24396-24403.
    • (2005) J Biol Chem , vol.280 , pp. 24396-24403
    • Cybulsky, A.V.1    Takano, T.2    Papillon, J.3    Bijian, K.4
  • 97
    • 0036828990 scopus 로고    scopus 로고
    • Complement c5b-9 membrane attack complex increases expression of endoplasmic reticulum stress proteins in glomerular epithelial cells
    • Cybulsky AV, Takano T, Papillon J, Khadir A, Liu J, Peng H: Complement c5b-9 membrane attack complex increases expression of endoplasmic reticulum stress proteins in glomerular epithelial cells. J Biol Chem 2002; 277: 41342-41351.
    • (2002) J Biol Chem , vol.277 , pp. 41342-41351
    • Cybulsky, A.V.1    Takano, T.2    Papillon, J.3    Khadir, A.4    Liu, J.5    Peng, H.6
  • 98
    • 44049098171 scopus 로고    scopus 로고
    • Preconditioning with endoplasmic reticulum stress ameliorates mesangioproliferative glomerulonephritis
    • Inagi R, Kumagai T, Nishi H, Kawakami T, Miyata T, Fujita T, Nangaku M: Preconditioning with endoplasmic reticulum stress ameliorates mesangioproliferative glomerulonephritis. J Am Soc Nephrol 2008; 19: 915-922.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 915-922
    • Inagi, R.1    Kumagai, T.2    Nishi, H.3    Kawakami, T.4    Miyata, T.5    Fujita, T.6    Nangaku, M.7
  • 99
    • 67349273027 scopus 로고    scopus 로고
    • MicroRNA in autoimmunity and autoimmune diseases
    • Pauley KM, Cha S, Chan EK: MicroRNA in autoimmunity and autoimmune diseases. J Autoimmun 2009; 32: 189-194.
    • (2009) J Autoimmun , vol.32 , pp. 189-194
    • Pauley, K.M.1    Cha, S.2    Chan, E.K.3
  • 101
    • 66949118228 scopus 로고    scopus 로고
    • Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel stat3-microRNA cluster 17/92 pathway
    • Brock M, Trenkmann M, Gay RE, Michel BA, Gay S, Fischler M, Ulrich S, Speich R, Huber LC: Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel stat3-microRNA cluster 17/92 pathway. Circ Res 2009; 104: 1184-1191.
    • (2009) Circ Res , vol.104 , pp. 1184-1191
    • Brock, M.1    Trenkmann, M.2    Gay, R.E.3    Michel, B.A.4    Gay, S.5    Fischler, M.6    Ulrich, S.7    Speich, R.8    Huber, L.C.9
  • 105
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N: Upstream and downstream of mTOR. Genes Dev 2004; 18: 1926-1945.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 106
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN: TOR signaling in growth and metabolism. Cell 2006; 124: 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 107
    • 12344262762 scopus 로고    scopus 로고
    • MTOR, translational control and human disease
    • Tee AR, Blenis J: mTOR, translational control and human disease. Semin Cell Dev Biol 2005; 16: 29-37.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 29-37
    • Tee, A.R.1    Blenis, J.2
  • 108
    • 22544455676 scopus 로고    scopus 로고
    • Identification of s6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
    • Holz MK, Blenis J: Identification of s6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem 2005; 280: 26089-26093.
    • (2005) J Biol Chem , vol.280 , pp. 26089-26093
    • Holz, M.K.1    Blenis, J.2
  • 109
    • 0036889291 scopus 로고    scopus 로고
    • Transduction of growth or mitogenic signals into translational activation of top mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither s6k1 nor rps6 phosphorylation
    • Stolovich M, Tang H, Hornstein E, Levy G, Cohen R, Bae SS, Birnbaum MJ, Meyuhas O: Transduction of growth or mitogenic signals into translational activation of top mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither s6k1 nor rps6 phosphorylation. Mol Cell Biol 2002; 22: 8101-8113.
    • (2002) Mol Cell Biol , vol.22 , pp. 8101-8113
    • Stolovich, M.1    Tang, H.2    Hornstein, E.3    Levy, G.4    Cohen, R.5    Bae, S.S.6    Birnbaum, M.J.7    Meyuhas, O.8
  • 110
    • 11144356304 scopus 로고    scopus 로고
    • S6k1(-/-)/s6k2(- /-) mice exhibit perinatal lethality and rapamycin- sensitive 5 -terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent s6 kinase pathway
    • Pende M, Um SH, Mieulet V, Sticker M, Goss VL, Mestan J, Mueller M, Fumagalli S, Kozma SC, Thomas G: S6k1(-/-)/s6k2(- /-) mice exhibit perinatal lethality and rapamycin- sensitive 5-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent s6 kinase pathway. Mol Cell Biol 2004; 24: 3112-3124.
    • (2004) Mol Cell Biol , vol.24 , pp. 3112-3124
    • Pende, M.1    Um, S.H.2    Mieulet, V.3    Sticker, M.4    Goss, V.L.5    Mestan, J.6    Mueller, M.7    Fumagalli, S.8    Kozma, S.C.9    Thomas, G.10
  • 112
    • 6344256753 scopus 로고    scopus 로고
    • MTOR: A protein kinase switching between life and death
    • Asnaghi L, Bruno P, Priulla M, Nicolin A: mTOR: A protein kinase switching between life and death. Pharmacol Res 2004; 50: 545-549.
    • (2004) Pharmacol Res , vol.50 , pp. 545-549
    • Asnaghi, L.1    Bruno, P.2    Priulla, M.3    Nicolin, A.4
  • 113
    • 67449104909 scopus 로고    scopus 로고
    • The tumour suppressor pdcd4: Recent advances in the elucidation of function and regulation
    • Lankat-Buttgereit B, Goke R: The tumour suppressor pdcd4: recent advances in the elucidation of function and regulation. Biol Cell 2009; 101: 309-317.
    • (2009) Biol Cell , vol.101 , pp. 309-317
    • Lankat-Buttgereit, B.1    Goke, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.