Inhibition of IkB kinase and NF-κB by a novel synthetic compound SK 2009

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 1, 2010, Pages 229-235

  Anchoori, Ravi Kumar ^a   Harikumar, Kuzhuvelil B ^b   Batchu, Venkateswara Rao ^c   Aggarwal, Bharat B ^b   Khan, Saeed R ^a,d  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

IKK; KBM 5 cells; NF B; Novel chemical entities; Simplactones; TNF

Indexed keywords

3 [2 [3 (BENZYLOXY) 1 HYDROXYPROPYL]DECANOYL] 4 BENZYLOXAZOLIDIN 2 ONE; 4 (2 (BENZYLOXY)ETHYL) 2,2 DIMETHYL 5 OCTYL 1,3 DIOXANE; 4 BENZYL 3 DECANOYLOXAZOLIDIN 2 ONE; 5 (BENZYLOXY) 2 HEPTYLPENTANE 1,3 DIOL; 5 (BENZYLOXY) 2 OCTYLPENTANE 1,3 DIOL; ANTINEOPLASTIC AGENT; CYCLIN D1; I KAPPA B; I KAPPA B KINASE; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; SIMPLACTONE; SK 2009; TETRAHYDRO 4 HYDROXY 5 TETRADECYLPYRAN 2 ONE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

CELL LINE, TUMOR; CELL SURVIVAL; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B KINASE; MOLECULAR STRUCTURE; NF-KAPPA B; PYRONES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 72149108163     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.065     Document Type: Article

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