The relationship between fibroblast growth and the dynamic stiffnesses of a DNA crosslinked hydrogel

Biomaterials

Volumn 31, Issue 6, 2010, Pages 1199-1212

  Jiang, Frank X ^a   Yurke, Bernard ^c   Schloss, Rene S ^a   Firestein, Bonnie L ^b   Langrana, Noshir A ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c Boise State University   (United States)

Author keywords

Aspect ratio; Crosslinking density; DNA crosslinked hydrogels; Dynamic stiffness; FAK expression; Projection area

Indexed keywords

CELL PROJECTION; CELL SHAPES; CELL TYPES; CONTROLLED DYNAMICS; CROSS-LINKED HYDROGELS; CROSS-LINKING DENSITY; DNA DELIVERY; DYNAMIC STIFFNESS; ENVIRONMENTAL FACTORS; FIBROBLAST GROWTH; IN-VIVO; MICROENVIRONMENTS; PATHOLOGICAL PROCESS; PROJECTION AREA; PROPERTY CHANGES; STATIC PROPERTIES;

ASPECT RATIO; BIOMATERIALS; BIOMIMETIC MATERIALS; BIOMIMETICS; CELL CULTURE; CROSSLINKING; DNA; DRUG THERAPY; ENZYME ACTIVITY; FIBROBLASTS; GENES; MATERIALS PROPERTIES; NUCLEIC ACIDS; PRESSURE DROP; STIFFNESS; TISSUE;

HYDROGELS;

BIOMATERIAL; DNA;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL POLARITY; CELL SHAPE; CELL SPECIFICITY; CELL STRAIN L 929; CONTROLLED STUDY; DNA CROSS LINKING; DNA SEQUENCE; FIBROBLAST CULTURE; GENE TARGETING; HYDROGEL; MECHANICAL STRESS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RIGIDITY;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL CULTURE TECHNIQUES; CELL LINE; CELL PROLIFERATION; CROSS-LINKING REAGENTS; CRYSTALLIZATION; DNA; ELASTIC MODULUS; FIBROBLASTS; HARDNESS; HYDROGELS; MATERIALS TESTING; MECHANOTRANSDUCTION, CELLULAR; RATS; SURFACE PROPERTIES; TISSUE ENGINEERING;

EID: 72149098571     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.10.050     Document Type: Article

References (51)

1. Lahann J., and Langer R. Smart materials with dynamically controllable surfaces. MRS Bull 30 (2005) 185-188
2. Mrksich M. Dynamic substrates for cell biology. MRS Bull 30 (2005) 180-184
3. Discher D.E., Janmey P., and Wang Y.L. Tissue cells feel and respond to the stiffness of their substrate. Science 310 (2005) 1139-1143
4. Franze K., Reichenbach A., and Käs J. Biomechanics of the CNS. In: Kamkim A., and Kiseleva I. (Eds). Mechanosensitivity of the nervous system (2009), Springer, Netherlands
5. Kruse S.A., Rose G.H., Glaser K.J., Manduca A., Felmlee J.P., Jack Jr. C.R., et al. Magnetic resonance elastography of the brain. Neuroimage 39 (2008) 231-237
6. Silver F.H., DeVore D., and Siperko L.M. Invited review: role of mechanophysiology in aging of ECM: effects of changes in mechanochemical transduction. J Appl Physiol 95 (2003) 2134-2141
7. Georges P.C., Hui J.J., Gombos Z., McCormick M.E., Wang A.Y., Uemura M., et al. Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis. Am J Physiol Gastrointest Liver Physiol 293 (2007) G1147-G1154
8. Huang S., and Ingber D.E. Cell tension, matrix mechanics, and cancer development. Cancer Cell 8 (2005) 175-176
9. Marquez J.P., Genin G.M., Pryse K.M., and Elson E.L. Cellular and matrix contributions to tissue construct stiffness increase with cellular concentration. Ann Biomed Eng 34 (2006) 1475-1482
10. Jiang F.X., Yurke B., Firestein B.L., and Langrana N.A. Neurite outgrowth on a DNA crosslinked hydrogel with tunable stiffnesses. Ann Biomed Eng 36 (2008) 1565-1579
11. Engler A.J., Sen S., Sweeney H.L., and Discher D.E. Matrix elasticity directs stem cell lineage specification. Cell 126 (2006) 677-689
12. Chen C.S., Jiang X., and Whitesides G.M. Microengineering the environment of mammalian cells in culture. MRS Bull 30 (2005) 194-201
13. Jiang X., Georges P.C., Li B., Du Y., Kutzing M.K., Previtera M.L., et al. Cell growth in response to mechanical stiffness is affected by neuron-astroglia interactions. Open Neurosci J 1 (2007) 7-14
14. Lin D., Langrana N., and Yurke B. Inducing reversible stiffness changes in DNA-crosslinked gels. J Mater Res 20 (2006) 1456-1464
15. Lin D.C., Yurke B., and Langrana N.A. Mechanical properties of a reversible, DNA-crosslinked polyacrylamide hydrogel. J Biomech Eng 126 (2004) 104-110
16. Yurke B., Turberfield A.J., Mills Jr. A.P., Simmel F.C., and Neumann J.L. A DNA-fuelled molecular machine made of DNA. Nature 406 (2000) 605-608
17. Cukierman E., Pankov R., Stevens D.R., and Yamada K.M. Taking cell-matrix adhesions to the third dimension. Scienc 294 (2001) 1708-1712
18. Geiger B. Cell biology. Encounters in space. Science 294 (2001) 1661-1663
19. Wang Y.L., and Pelham Jr. R.J. Preparation of a flexible, porous polyacrylamide substrate for mechanical studies of cultured cells. Meth Enzymol 298 (1998) 489-496
20. Sundararaghavan H.G., Monteiro G.A., Lapin N.A., Chabal Y.J., Miksan J.R., and Shreiber D.I. Genipin-induced changes in collagen gels: correlation of mechanical properties to fluorescence. J Biomed Mater Res A 87 (2008) 308-320
21. Georges P.C., Miller W.J., Meaney D.F., Sawyer E.S., and Janmey P.A. Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures. Biophys J 90 (2006) 3012-3018
22. Bischofs I.B., Safran S.A., and Schwarz U.S. Elastic interactions of active cells with soft materials. Phys Rev 69 (2004) 021911
23. Chen C.S., Tan J., and Tien J. Mechanotransduction at cell-matrix and cell-cell contacts. Annu Rev Biomed Eng 6 (2004) 275-302
24. Yeung T., Georges P.C., Flanagan L.A., Marg B., Ortiz M., Funaki M., et al. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton 60 (2005) 24-34
25. Li F., Li B., Wang Q.M., and Wang J.H. Cell shape regulates collagen type I expression in human tendon fibroblasts. Cell Motil Cytoskeleton 65 (2008) 332-341
26. Dubin-Thaler B.J., Giannone G., Dobereiner H.G., and Sheetz M.P. Nanometer analysis of cell spreading on matrix-coated surfaces reveals two distinct cell states and STEPs. Biophys J 86 (2004) 1794-1806
27. Wang N., Ostuni E., Whitesides G.M., and Ingber D.E. Micropatterning tractional forces in living cells. Cell Motil Cytoskeleton 52 (2002) 97-106
28. Shreiber D.I., Barocas V.H., and Tranquillo R.T. Temporal variations in cell migration and traction during fibroblast-mediated gel compaction. Biophys J 84 (2003) 4102-4114
29. Wells R.G. The role of matrix stiffness in regulating cell behavior. Hepatology 47 (2008) 1394-1400
30. Altschul S.F., Gish W., Miller W., Myers E.W., and Lipman D.J. Basic local alignment search tool. J Mol Biol 215 (1990) 403-410
31. James J., Goluch E.D., Hu H., Liu C., and Mrksich M. Subcellular curvature at the perimeter of micropatterned cells influences lamellipodial distribution and cell polarity. Cell Motil Cytoskeleton 65 (2008) 841-852
32. Wang Q., Xian W., Li S., Liu C., and Padua G.W. Topography and biocompatibility of patterned hydrophobic/hydrophilic zein layers. Acta Biomater 4 (2008) 844-851
33. Beningo K.A., Dembo M., and Wang Y.L. Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors. Proc Natl Acad Sci U S A 101 (2004) 18024-18029
34. Solon J., Levental I., Sengupta K., Georges P.C., and Janmey P.A. Fibroblast adaptation and stiffness matching to soft elastic substrates. Biophys J 93 (2007) 4453-4461
35. Chen C.S., Mrksich M., Huang S., Whitesides G.M., and Ingber D.E. Geometric control of cell life and death. Science 276 (1997) 1425-1428
36. Singhvi R., Kumar A., Lopez G.P., Stephanopoulos G.N., Wang D.I., Whitesides G.M., et al. Engineering cell shape and function. Science 264 (1994) 696-698
37. Goldmann W.H. Mechanical aspects of cell shape regulation and signaling. Cell Biol Int 26 (2002) 313-317
38. Ingber D.E. Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology. Circ Res 91 (2002) 877-887
39. Bao G., and Suresh S. Cell and molecular mechanics of biological materials. Nat Mater 2 (2003) 715-725
40. Wottawah F., Schinkinger S., Lincoln B., Ananthakrishnan R., Romeyke M., Guck J., et al. Optical rheology of biological cells. Phys Rev Lett 94 (2005) 098103
41. Bershadsky A.D., Balaban N.Q., and Geiger B. Adhesion-dependent cell mechanosensitivity. Annu Rev Cell Dev Biol 19 (2003) 677-695
42. Pelham Jr. R.J., and Wang Y. Cell locomotion and focal adhesions are regulated by substrate flexibility. Proc Natl Acad Sci U S A 94 (1997) 13661-13665
43. Janmey P.A., and Weitz D.A. Dealing with mechanics: mechanisms of force transduction in cells. Trends Biochem Sci 29 (2004) 364-370
44. Zhu C., Bao G., and Wang N. Cell mechanics: mechanical response, cell adhesion, and molecular deformation. Annu Rev Biomed Eng 2 (2000) 189-226
45. De R., Zemel A., and Safran S.A. Do cells sense stress or strain? Measurement of cellular orientation can provide a clue. Biophys J 94 (2008) L29-L31
46. Saez A., Ghibaudo M., Buguin A., Silberzan P., and Ladoux B. Rigidity-driven growth and migration of epithelial cells on microstructured anisotropic substrates. Proc Natl Acad Sci U S A 104 (2007) 8281-8286
47. Chicurel M.E., Chen C.S., and Ingber D.E. Cellular control lies in the balance of forces. Curr Opin Cell Biol 10 (1998) 232-239
48. Thoumine O. Control of cellular morphology by mechanical factors. Journal de Physique III 6 (1996) 1555-1566
49. Paszek M.J., and Weaver V.M. The tension mounts: mechanics meets morphogenesis and malignancy. J Mammary Gland Biol Neoplasia 9 (2004) 325-342
50. Bischofs I.B., and Schwarz U.S. Cell organization in soft media due to active mechanosensing. Proc Natl Acad Sci U S A 100 (2003) 9274-9279
51. Katz B.Z., Zamir E., Bershadsky A., Kam Z., Yamada K.M., and Geiger B. Physical state of the extracellular matrix regulates the structure and molecular composition of cell-matrix adhesions. Mol Biol Cell 11 (2000) 1047-1060