Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study

Osteoarthritis and Cartilage

Volumn 18, Issue 1, 2010, Pages 47-53

  Roemer, F W ^a,b   Neogi, T ^c   Nevitt, M C ^d   Felson, D T ^c   Zhu, Y ^c   Zhang, Y ^c   Lynch, J A ^d   Javaid, M K ^d,e   Crema, M D ^a   Torner, J ^f   Lewis, C E ^g   Guermazi, A ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b KLINIKUM AUGSBURG   (Germany)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f UNIVERSITY OF IOWA   (United States)

^g University of Alabama at Birmingham   (United States)

Author keywords

Attrition; Bone; Bone marrow lesions; Knee; Magnetic resonance imaging; Osteoarthritis

Indexed keywords

ADULT; AGED; ARTICLE; BONE LESION; BONE REMODELING; BONE STRESS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; INCIDENCE; KNEE OSTEOARTHRITIS; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSERVATIONAL STUDY; PREDICTION; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR;

AGED; BONE MARROW DISEASES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INCIDENCE; KNEE JOINT; LOGISTIC MODELS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE;

EID: 72149089307     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2009.08.018     Document Type: Article

References (47)

1. Arthritis prevalence and activity limitations - United States, 1990. MMWR Morb Mortal Wkly Rep 43 (1994) 433-438
2. Prevalence of disabilities and associated health conditions among adults - United States, 1999. MMWR Morb Mortal Wkly Rep 50 (2001) 120-125
3. Felson D.T., McLaughlin S., Goggins J., LaValley M.P., Gale M.E., Totterman S., et al. Bone marrow edema and its relation to progression of knee osteoarthritis. Ann Intern Med 139 (2003) 330-336
4. Hunter D.J., Zhang Y., Niu J., Goggins J., Amin S., LaValley M.P., et al. Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis. Arthritis Rheum 54 (2006) 1529-1535
5. Guermazi A., Zaim S., Taouli B., Miaux Y., Peterfy C.G., and Genant H.K. MR findings in knee osteoarthritis. Eur Radiol 13 (2003) 1370-1386
6. Pelletier J.P., Martel-Pelletier J., and Abramson S.B. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum 44 (2001) 1237-1247
7. Amin S., Guermazi A., Lavalley M.P., Niu J., Clancy M., Hunter D.J., et al. Complete anterior cruciate ligament tear and the risk for cartilage loss and progression of symptoms in men and women with knee osteoarthritis. Osteoarthritis Cartilage 16 (2008) 897-902
8. Roemer F.W., Guermazi A., Javaid M.K., Lynch J.A., Niu J., Zhang Y., et al. Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss - the MOST study a longitudinal multicenter study of knee osteoarthritis. Ann Rheum Dis 68 (2009) 1461-1465
9. Dedrick D.K., Goldstein S.A., Brandt K.D., O'Connor B.L., Goulet R.W., and Albrecht M. A longitudinal study of subchondral plate and trabecular bone in cruciate-deficient dogs with osteoarthritis followed up for 54 months. Arthritis Rheum 36 (1993) 1460-1467
10. Raynauld J.P., Martel-Pelletier J., Berthiaume M.J., Abram F., Choquette D., Haraoui B., et al. Correlation between bone lesion changes and cartilage volume loss in patients with osteoarthritis of the knee as assessed by quantitative magnetic resonance imaging over a 24-month period. Ann Rheum Dis 67 (2008) 683-688
11. Hunter D.J., Gerstenfeld L., Bishop G., Davis A.D., Mason Z.D., Einhorn T.A., et al. Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized. Arthritis Res Ther 11 (2009) R11
12. Dieppe P., Cushnaghan J., Young P., and Kirwan J. Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy. Ann Rheum Dis 52 (1993) 557-563
13. Carlson C.S., Loeser R.F., Jayo M.J., Weaver D.S., Adams M.R., and Jerome C.P. Osteoarthritis in cynomolgus macaques: a primate model of naturally occurring disease. J Orthop Res 12 (1994) 331-339
14. Radin E.L., Martin R.B., Burr D.B., Caterson B., Boyd R.D., and Goodwin C. Effects of mechanical loading on the tissues of the rabbit knee. J Orthop Res 2 (1984) 221-234
15. Radin E.L., and Rose R.M. Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res (1986) 34-40
16. Anderson-MacKenzie J.M., Quasnichka H.L., Starr R.L., Lewis E.J., Billingham M.E., and Bailey A.J. Fundamental subchondral bone changes in spontaneous knee osteoarthritis. Int J Biochem Cell Biol 37 (2005) 224-236
17. Hayami T., Pickarski M., Zhuo Y., Wesolowski G.A., Rodan G.A., and Duong le T. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone 38 (2006) 234-243
18. Hernandez-Molina G., Neogi T., Hunter D.J., Niu J., Guermazi A., Roemer F.W., et al. The association of bone attrition with knee pain and other MRI features of osteoarthritis. Ann Rheum Dis 67 (2008) 43-47
19. Reichenbach S., Guermazi A., Niu J., Neogi T., Hunter D.J., Roemer F.W., et al. Prevalence of bone attrition on knee radiographs and MRI in a community-based cohort. Osteoarthritis Cartilage 16 (2008 Sep) 1005-1010
20. Peterfy C.G., Guermazi A., Zaim S., Tirman P.F., Miaux Y., White D., et al. Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage 12 (2004) 177-190
21. Juni P., Reichenbach S., and Dieppe P. Osteoarthritis: rational approach to treating the individual. Best Pract Res Clin Rheumatol 20 (2006) 721-740
22. Torres L., Dunlop D.D., Peterfy C., Guermazi A., Prasad P., Hayes K.W., et al. The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis. Osteoarthritis Cartilage 14 (2006) 1033-1040
23. Neogi T., Zhang Y., Niu J., Lynch J., Nevitt M.C., Guermazi A., et al. Cartilage loss occurs in the same subregions as subchondral bone attrition: the MOST study. Arthritis Rheum 58 (2008) S235
24. Neogi T, Nevitt MC, Niu J, Sharma L, Roemer F, Guermazi A, et al. Subchondral bone attrition is a reflection of compartment-specific mechanical load: the MOST study. Ann Rheum Dis 2009 Sep 17 [Epub ahead of print].
25. Sharma L., Eckstein F., Song J., Guermazi A., Prasad P., Kapoor D., et al. Relationship of meniscal damage, meniscal extrusion, malalignment, and joint laxity to subsequent cartilage loss in osteoarthritic knees. Arthritis Rheum 58 (2008) 1716-1726
26. Zanetti M., Bruder E., Romero J., and Hodler J. Bone marrow edema pattern in osteoarthritic knees: correlation between MR imaging and histologic findings. Radiology 215 (2000) 835-840
27. Martig S., Boisclair J., Konar M., Spreng D., and Lang J. MRI characteristics and histology of bone marrow lesions in dogs with experimentally induced osteoarthritis. Vet Radiol Ultrasound 48 (2007) 105-112
28. Bergman A.G., Willen H.K., Lindstrand A.L., and Pettersson H.T. Osteoarthritis of the knee: correlation of subchondral MR signal abnormalities with histopathologic and radiographic features. Skeletal Radiol 23 (1994) 445-448
29. Roemer F.W., Frobell R., Hunter D.J., Crema M.D., Fischer W., Bohndorf K., et al. MRI-detected subchondral bone marrow signal alterations of the knee joint: terminology, imaging appearance, relevance and radiological differential diagnosis. Osteoarthritis Cartilage 17 (2009) 1115-1131
30. Karlson E.W., Sanchez-Guerrero J., Wright E.A., Lew R.A., Daltroy L.H., Katz J.N., et al. A connective tissue disease screening questionnaire for population studies. Ann Epidemiol 5 (1995) 297-302
31. Felson D.T., Niu J., Guermazi A., Roemer F.W., Aliabadi P., Clancy M., et al. The development of knee pain correlates with enlarging bone marrow lesions on MRI. Arthritis Rheum 56 (2007) 2986-2992
32. Peterfy C.G., Guermazi A., and Zaim P.F. Non-fluoroscopic method for flexed radiography of the knee that allows reproducible joint-space width measurement. Arthritis Rheum 41 (1998) S361
33. Burr D.B. The importance of subchondral bone in the progression of osteoarthritis. J Rheumatol Suppl 70 (2004) 77-80
34. Felson D.T., Chaisson C.E., Hill C.L., Totterman S.M., Gale M.E., Skinner K.M., et al. The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med 134 (2001) 541-549
35. Vellet A.D., Marks P.H., Fowler P.J., and Munro T.G. Occult posttraumatic osteochondral lesions of the knee: prevalence, classification, and short-term sequelae evaluated with MR imaging. Radiology 178 (1991) 271-276
36. Yamamoto T., and Bullough P.G. Spontaneous osteonecrosis of the knee: the result of subchondral insufficiency fracture. J Bone Joint Surg Am 82 (2000) 858-866
37. Frobell R.B., Roos H.P., Roos E.M., Hellio Le Graverand M.P., Buck R., Tamez-Pena J., et al. The acutely ACL injured knee assessed by MRI: are large volume traumatic bone marrow lesions a sign of severe compression injury?. Osteoarthritis Cartilage 16 (2008) 829-836
38. Korompilias A.V., Karantanas A.H., Lykissas M.G., and Beris A.E. Bone marrow edema syndrome. Skeletal Radiol 38 (2009) 425-436
39. Moosikasuwan J.B., Miller T.T., Math K., and Schultz E. Shifting bone marrow edema of the knee. Skeletal Radiol 33 (2004) 380-385
40. Lee S.K., Suh K.J., Kim Y.W., Ryeom H.K., Kim Y.S., Lee J.M., et al. Septic arthritis versus transient synovitis at MR imaging: preliminary assessment with signal intensity alterations in bone marrow. Radiology 211 (1999) 459-465
41. Lahm A., Spank H., Mrosek E., Frauendorf H., and Merk H. Relevance of different sequences in MRI-detected subchondral bone damage of the knee joint and possible therapeutic options. Sportverletz Sportschaden 22 (2008) 38-44
42. Boks S.S., Vroegindeweij D., Koes B.W., Bernsen R.M., Hunink M.G., and Bierma-Zeinstra S.M. Clinical consequences of posttraumatic bone bruise in the knee. Am J Sports Med 35 (2007) 990-995
43. Frobell R.B., Le Graverand M.P., Buck R., Roos E.M., Roos H.P., Tamez-Pena J., et al. The acutely ACL injured knee assessed by MRI: changes in joint fluid, bone marrow lesions, and cartilage during the first year. Osteoarthritis Cartilage 17 (2009) 161-167
44. Vincken P.W., Ter Braak B.P., van Erkel A.R., Coerkamp E.G., Mallens W.M., and Bloem J.L. Clinical consequences of bone bruise around the knee. Eur Radiol 16 (2006) 97-107
45. Sanders T.G., Medynski M.A., Feller J.F., and Lawhorn K.W. Bone contusion patterns of the knee at MR imaging: footprint of the mechanism of injury. Radiographics 20 (2000) S135-S151
46. Palmer W.E. Magnetic resonance imaging of knee trauma: biomechanical approach. Top Magn Reson Imaging 14 (2003) 161-178
47. Yu J.S., and Cook P.A. Magnetic resonance imaging (MRI) of the knee: a pattern approach for evaluating bone marrow edema. Crit Rev Diagn Imaging 37 (1996) 261-303