Augmentation of Degenerated Human Cartilage In Vitro Using Magnetically Labeled Mesenchymal Stem Cells and an External Magnetic Device

Arthroscopy - Journal of Arthroscopic and Related Surgery

Volumn 25, Issue 12, 2009, Pages 1435-1441

  Kobayashi, Takaaki ^a   Ochi, Mitsuo ^a   Yanada, Shinobu ^a   Ishikawa, Masakazu ^a   Adachi, Nobuo ^a   Deie, Masataka ^a   Arihiro, Koji ^b  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cell delivery system; Degenerated cartilage; Magnetic force; Mesenchymal stem cell; Regeneration

Indexed keywords

COLLAGEN TYPE 2; DYE; SAFRANIN O; TOLONIUM CHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; BONE MARROW CELL; CARTILAGE DEGENERATION; CELL DIFFERENTIATION; CELL LABELING; CONTROLLED STUDY; DEVICE; EXTRACELLULAR MATRIX; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAGNETISM; MESENCHYMAL STEM CELL; OSTEOARTHRITIS; REGENERATION; TOTAL KNEE REPLACEMENT;

CARTILAGE, ARTICULAR; CELL DIFFERENTIATION; CELLS, CULTURED; GUIDED TISSUE REGENERATION; HUMANS; JOINT DISEASES; KNEE JOINT; MAGNETICS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; TISSUE ENGINEERING;

EID: 72049133444     PISSN: 07498063     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arthro.2009.06.009     Document Type: Article

References (17)

1. Elders M.J. The increasing impact of arthritis on public health. J Rheumatol 60 Suppl (2000) 6-8
2. Murphy J.M., Fink D.J., Hunziker E.B., and Barry F.P. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum 48 (2003) 3464-3474
3. Nishimori M., Deie M., Kanaya A., Exham H., Adachi N., and Ochi M. Repair of chronic osteochondral defects in the rat. A bone marrow-stimulating procedure enhanced by cultured allogenic bone marrow mesenchymal stromal cells. J Bone Joint Surg Br 88 (2006) 1236-1244
4. Wakitani S., Imoto K., Yamamoto T., Saito M., Murata N., and Yoneda M. Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage 10 (2002) 199-206
5. Pittenger M.F., Mackay A.M., Beck S.C., et al. Multilineage potential of adult human mesenchymal stem cells. Science 284 (1999) 143-147
6. Jiang Y., Jahagirdar B.N., Reinhardt R.L., et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418 (2002) 41-49
7. Agung M., Ochi M., Yanada S., et al. Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration. Knee Surg Sports Traumatol Arthrosc 14 (2006) 1307-1314
8. Ochi M., Adachi N., Nobuto H., Yanada S., Ito Y., and Agung M. Articular cartilage repair using tissue engineering technique-Novel approach with minimally invasive procedure. Artif Organs 28 (2004) 28-32
9. Kobayashi T., Ochi M., Yanada S., et al. A novel cell delivery system using magnetically labeled mesenchymal stem cells and an external magnetic device for clinical cartilage repair. Arthroscopy 24 (2008) 69-76
10. Outerbridge R.E. The etiology of chondromalacia patellae. J Bone Joint Surg Br 43 (1961) 752-757
11. Mankin H.J. Biochemical and metabolic aspects of osteoarthritis. Orthop Clin North Am 2 (1971) 19-31
12. Yanada S., Ochi M., Adachi N., et al. Effects of CD44 antibody- or RGDS peptide-immobilized magnetic beads on cell proliferation and chondrogenesis of mesenchymal stem cells. J Biomed Mater Res A 77 (2006) 773-784
13. Motoyama M., Deie M., Ochi M., et al. In vitro cartilage formation using TGF-immobilized magnetic beads and mesenchymal stem cell-magnetic bead complexes under magnetic field conditions. J Biomed Mater Res A (2009 Jan 26) [Epub ahead of print.]
14. Hamasaki T., Tanaka N., Ochi M., et al. Characterization of labeled neural progenitor cells for magnetic targeting. Neuroreport 16 (2005) 1641-1645
15. Nishida K., Tanaka N., Ochi M., et al. Magnetic targeting of bone marrow stromal cells into spinal cord: Through cerebrospinal fluid. Neuroreport 17 (2006) 1269-1272
16. Hamasaki T., Tanaka N., Ochi M., et al. Magnetically labeled neural progenitor cells, which are localized by magnetic force, promote axon growth in organotypic cocultures. Spine 32 (2007) 2300-2305
17. Sugioka T., Ochi M., Yasunaga Y., Adachi N., and Yanada S. Accumulation of magnetically labeled rat mesenchymal stem cells using an external magnetic force, and their potential for bone regeneration. J Biomed Mater Res A 85 (2008) 597-604