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Volumn 877, Issue 31, 2009, Pages 4065-4070
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Rapid online proteolytic mapping of PEGylated rhGH for identity confirmation, quantitation of methionine oxidation and quantitation of UnPEGylated N-terminus using HPLC with UV detection
a
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Author keywords
Chromatography; Growth hormone; Mapping; Online; PEGylated
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Indexed keywords
ANALYSIS TIME;
BIOPHARMACEUTICAL INDUSTRY;
COLUMN SWITCHING;
DIGESTION PROCEDURE;
GROWTH HORMONE;
GROWTH HORMONES;
INTEGRATED SYSTEMS;
INTEGRATED TECHNIQUES;
METHIONINE OXIDATION;
N-TERMINALS;
ON-LINE PROCEDURES;
PEAK AREA;
POST-TRANSLATION MODIFICATION;
PROTEIN IDENTITY;
REFERENCE STANDARD;
RP-HPLC;
SAMPLE LOOP;
TRYPTIC PEPTIDES;
UV DETECTION;
AMINES;
CHROMATOGRAPHIC ANALYSIS;
CHROMATOGRAPHY;
INTEGRATED OPTICS;
MAPPING;
OXIDATION;
PEPTIDES;
ULTRAVIOLET DETECTORS;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HUMAN GROWTH HORMONE;
METHIONINE;
AMINO TERMINAL SEQUENCE;
ARTICLE;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
OXIDATION;
PEPTIDE MAPPING;
PRIORITY JOURNAL;
PROTEIN DEGRADATION;
SENSITIVITY AND SPECIFICITY;
ULTRAVIOLET RADIATION;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
HUMAN GROWTH HORMONE;
HYDROLYSIS;
INTERNET;
METHIONINE;
OXIDATION-REDUCTION;
PEPTIDE FRAGMENTS;
POLYETHYLENE GLYCOLS;
PROTEOMICS;
RECOMBINANT PROTEINS;
SPECTROPHOTOMETRY, ULTRAVIOLET;
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EID: 72049122976
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2009.10.015 Document Type: Article |
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Times cited : (8)
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References (17)
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