Metabolic profiling of infant urine using comprehensive two-dimensional gas chromatography: Application to the diagnosis of organic acidurias and biomarker discovery

Journal of Chromatography A

Volumn 1217, Issue 1, 2010, Pages 104-111

  Kouremenos, Konstantinos A ^a   Pitt, James ^b,c   Marriott, Philip J ^a  

^a RMIT UNIVERSITY   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Comprehensive two dimensional gas chromatography (GC GC); Derivatization; Enzyme deficiency; Metabolite profiling; Time of flight mass spectrometry (ToFMS); Urinary organic acids

Indexed keywords

COMPREHENSIVE TWO-DIMENSIONAL GAS CHROMATOGRAPHY; DERIVATIZATIONS; ENZYME DEFICIENCIES; METABOLITE PROFILING; TIME OF FLIGHT MASS SPECTROMETRY; TIME-OF-FLIGHT MASS SPECTROMETRY (TOFMS);

BIOMOLECULES; CHROMATOGRAPHIC ANALYSIS; ENZYMES; ISOTOPES; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; ORGANIC ACIDS; RADIOISOTOPES; SMOKE DETECTORS; TWO DIMENSIONAL;

GAS CHROMATOGRAPHY;

BIOLOGICAL MARKER; CARBOXYLIC ACID; CROTONYL GLYCINE; DICARBOXYLIC ACID; GLYCINE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; METHYLCROTONOYL COENZYME A CARBOXYLASE; METHYLMALONIC ACID; UNCLASSIFIED DRUG;

ACIDURIA; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; ENZYME DEFICIENCY; GAS CHROMATOGRAPHY; HUMAN; INFANT; ISOTOPE DILUTION ASSAY; METABOLITE; METHYLMALONIC ACIDEMIA; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; TIME OF FLIGHT MASS SPECTROMETRY; URINALYSIS; URINE COMPOSITION DISORDER; URINE LEVEL;

AMINO ACID METABOLISM, INBORN ERRORS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; INFANT; MALE; METABOLOME;

EID: 72049117104     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2009.10.033     Document Type: Article

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