2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 1, 2010, Pages 346-349

  Smith, Cameron J ^a   Ali, Amjad ^a   Chen, Liya ^a   Hammond, Milton L ^a   Anderson, Matt S ^a   Chen, Ying ^a   Eveland, Suzanne S ^a   Guo, Qiu ^a   Hyland, Sheryl A ^a   Milot, Denise P ^a   Sparrow, Carl P ^a   Wright, Samuel D ^a   Sinclair, Peter J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Benzoxazole; CETP; Cholesteryl ester transfer protein; HDL; High density lipoprotein

Indexed keywords

2 ARYLBENZOXAZOLE DERIVATIVE; BENZOXAZOLE DERIVATIVE; CHOLESTEROL ESTER TRANSFER PROTEIN INHIBITOR; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; IC 50; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ACETANILIDES; ADMINISTRATION, ORAL; ANIMALS; ANTICHOLESTEREMIC AGENTS; BENZOXAZOLES; CHOLESTEROL ESTER TRANSFER PROTEINS; MICE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72049109420     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.099     Document Type: Article

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31. 4) and concentrated in vacuo to afford the crude product. This was purified by flash chromatography and/or reversed phase HPLC to afford the desired benzoxazole.