Clozapine chronically suppresses alcohol drinking in Syrian golden hamsters

Neuropharmacology

Volumn 58, Issue 2, 2010, Pages 351-356

  Chau, David T ^a   Gulick, Danielle ^a   Xie, Haiyi ^a,b   Dawson, Ree ^c   Green, Alan I ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b Department of Community and Family Medicine ^*  (United States)

^c Frontier Science and Technology Research Foundation   (United States)

Author keywords

Alcoholism; Blood alcohol level; Clozapine; Hamster; Schizophrenia; Sucrose

Indexed keywords

ALCOHOL; CLOZAPINE; SUCROSE; WATER;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; DRUG DOSE COMPARISON; DRUG TOLERANCE; FLUID INTAKE; FOOD INTAKE; MALE; NONHUMAN; PRIORITY JOURNAL; SYRIAN HAMSTER; TIME; TREATMENT DURATION; TREATMENT OUTCOME; WEIGHT GAIN;

ALCOHOL DRINKING; ANIMALS; ANTIPSYCHOTIC AGENTS; CLOZAPINE; CRICETINAE; DIETARY SUCROSE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING BEHAVIOR; ETHANOL; FEEDING BEHAVIOR; MALE; MESOCRICETUS; PSYCHOTROPIC DRUGS; RANDOM ALLOCATION; TIME FACTORS; WATER;

EID: 72049091202     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2009.10.006     Document Type: Article

References (24)

1. Alterman A.I., Erdlen F.R., and Murphy E. Alcohol abuse in the psychiatric hospital population. Addict. Behav. 6 (1981) 69-73
2. Baldessarini R.J., Centorrino F., Flood J.G., Volpicelli S.A., Huston-Lyons D., and Cohen B.M. Tissue concentrations of clozapine and its metabolites in the rat. Neuropsychopharmacology 9 (1993) 117-124
3. Czachowski C.L., and Delory M.J. Acamprosate and naltrexone treatment effects on ethanol and sucrose seeking and intake in ethanol-dependent and nondependent rats. Psychopharmacology (Berl) (2009)
4. Drake R.E., and Mueser K.T. Alcohol-use disorder and severe mental illness. Alcohol Health Res. World 20 (1996) 87-93
5. Drake R.E., Osher F.C., and Wallach M.A. Alcohol use and abuse in schizophrenia. A prospective community study. J. Nerv. Ment. Dis. 177 (1989) 408-414
6. Gardner E.L., and Seeger T.F. Neurobehavioral evidence for mesolimbic specificity of action by clozapine: studies using electrical intracranial self-stimulation. Biol. Psychiatry 18 (1983) 1357-1362
7. Gardner E.L., and Seeger T.F. Anatomically selective action of atypical neuroleptics on the mesocorticolimbic dopamine system. Ann. N.Y. Acad. Sci. 537 (1988) 479-481
8. Green A.I., Chau D.T., Keung W.M., Dawson R., Mesholam R.I., and Schildkraut J.J. Clozapine reduces alcohol drinking in Syrian golden hamsters. Psychiatry Res. 128 (2004) 9-20
9. Green A.I., Noordsy D.L., Brunette M.F., and O'Keefe C. Substance abuse and schizophrenia: pharmacotherapeutic intervention. J. Subst. Abuse Treat. 34 (2008) 61-71
10. Green A.I., Zimmet S.V., Strous R.D., and Schildkraut J.J. Clozapine for comorbid substance use disorder and schizophrenia: do patients with schizophrenia have a reward-deficiency syndrome that can be ameliorated by clozapine?. Harv. Rev. Psychiatry 6 (1999) 287-296
11. Gupta S., Hendricks S., Kenkel A.M., Bhatia S.C., and Haffke E.A. Relapse in schizophrenia: is there a relationship to substance abuse?. Schizophr. Res. 20 (1996) 153-156
12. Ingman K., and Korpi E.R. Alcohol drinking of alcohol-preferring AA rats is differentially affected by clozapine and olanzapine. Eur. J. Pharmacol. 534 (2006) 133-140
13. June H.L., Domangue K.R., Hughes R.W., Spurlock H.L., and Lewis M.J. Differential effects of dopamine and serotonin antagonists on ethanol self-administration. Alcohol. Clin. Exp. Res. 15 (1991) 316
14. Keung W.M., Kunze L., Li D.J., and Lazo O. Volitional ethanol consumption affects overall serotonin metabolism in Syrian golden hamsters (Mesocricetus auratus). Biochem. Biophys. Res. Commun. 271 (2000) 823-830
15. McMillan D.E., Ellis F.W., Frye G.D., and Pick J.R. Failure of signs of physical dependence to develop in hamsters after prolonged consumption of large doses of ethanol. Pharmacol. Biochem. Behav. 7 (1977) 55-57
16. Nowak K.L., McKinzie D.L., McBride W.J., and Murphy J.M. Patterns of ethanol and saccharin intake in P rats under limited-access conditions. Alcohol 19 (1999) 85-96
17. Owen R.R., Fischer E.P., Booth B.M., and Cuffel B.J. Medication noncompliance and substance abuse among patients with schizophrenia. Psychiatr. Serv. 47 (1996) 853-858
18. Regier D.A., Farmer M.E., Rae D.S., Locke B.Z., Keith S.J., Judd L.L., and Goodwin F.K. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA 264 (1990) 2511-2518
19. Sharpe A.L., and Samson H.H. Effect of naloxone on appetitive and consummatory phases of ethanol self-administration. Alcohol. Clin. Exp. Res. 25 (2001) 1006-1011
20. Stromberg M.F., Rukstalis M.R., Mackler S.A., Volpicelli J.R., and O'Brien C.P. A comparison of the effects of 6-beta naltrexol and naltrexone on the consumption of ethanol or sucrose using a limited-access procedure in rats. Pharmacol. Biochem. Behav. 72 (2002) 483-490
21. Sun L., and Lau C.E. Intravenous and oral clozapine pharmacokinetics, pharmacodynamics, and concentration-effect relations: acute tolerance. Eur. J. Pharmacol. 398 (2000) 225-238
22. Thrasher M.J., Freeman P.A., and Risinger F.O. Clozapine's effects on ethanol's motivational properties. Alcohol Clin. Exp. Res. 23 (1999) 1377-1385
23. Ufer M., Dadmarz M., and Vogel W.H. Voluntary consumption of amphetamine, cocaine, ethanol and morphine by rats as influenced by a preceding period of forced drug intake and clozapine. Pharmacology 58 (1999) 285-291
24. Youngren K.D., Moghaddam B., Bunney B.S., and Roth R.H. Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment. Neurosci. Lett. 165 (1994) 41-44