Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 1, 2010, Pages 206-208

  Čapková, Kateřina ^a   Hixon, Mark S ^b   Pellett, Sabine ^c   Barbieri, Joseph T ^d   Johnson, Eric A ^c   Janda, Kim D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Takeda San Diego Inc   (United States)

^c UNIVERSITY OF WISCONSIN   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Botulinum neurotoxin; Irreversible inhibition; Protease inhibitor

Indexed keywords

BENZYLIDENE CYCLOPENTENEDIONE DERIVATIVE; BOTULINUM TOXIN A; MALEIMIDE DERIVATIVE; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; ZINC PROTEASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; RAT;

BENZYLIDENE COMPOUNDS; BOTULINUM TOXIN TYPE A; CATALYTIC DOMAIN; CYCLOPENTANES; METALLOENDOPEPTIDASES; PROTEASE INHIBITORS; ZINC;

EID: 72049088765     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.129     Document Type: Article

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