Role of hydrodynamics in supercritical antisolvent processes

Journal of Supercritical Fluids

Volumn 51, Issue 2, 2009, Pages 248-255

  Petit Gas, T ^a   Boutin, O ^a   Raspo, I ^a   Badens, E ^a  

^a CNRS   (France)

Author keywords

Crystallization; Dispersion; Hydrodynamics; Particle processing; Process control; Supercritical fluid

Indexed keywords

EXPERIMENTAL STUDIES; FINE PARTICLES; HOMOGENEOUS POWDERS; JET BREAKUP; JET VELOCITIES; LIQUID JETS; LIQUID PHASE; MIXING STATE; NUCLEATION ZONE; ORGANIC SOLUTIONS; PARTICLE PROCESSING; SULFATHIAZOLE; SUPERCRITICAL ANTISOLVENT PROCESS;

ATOMIZATION; CRYSTALLIZATION; DISPERSIONS; EFFLUENT TREATMENT; FLUID DYNAMICS; HYDRODYNAMICS; JETS; LIQUIDS; SUPERCRITICAL FLUID EXTRACTION; SUPERCRITICAL FLUIDS; SYNTHETIC APERTURE SONAR;

PROCESS CONTROL;

EID: 72049086686     PISSN: 08968446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.supflu.2009.07.013     Document Type: Article

References (23)

1. Charbit G., Badens E., and Boutin O. Methods of particle production. In: York P., Kompella U.B., and Shekunov B.Y. (Eds). Supercritical Fluid Technology for Drug Product Development (2004) 159
2. Yeo S.D., and Kiran E. Formation of polymer particles with supercritical fluids: a review. The Journal of Supercritical Fluids 34 (2005) 287-308
3. Majerik V., Charbit G., Badens E., Horváth G., Szokonya L., Bosc N., and Teillaud E. Bioavailibility enhancement of an active substance by supercritical fluid antisolvent precipitation. The Journal of Supercritical Fluids 40 (2007) 101-110
4. Reverchon E., De Marco I., and Torino E. Nanoparticles production by supercritical antisolvent precipitation: a general interpretation. The Journal of Supercritical Fluids 43 (2007) 126-138
5. Kordikowski A., Shekunov B.Y., and York P. Polymorph control of sulfathiazole in supercritical carbon dioxide. Pharmaceutical Research 18 (2001) 682-688
6. Edwards A.D., Shekunov B.Y., Grossmann J.G., Forbes R.T., and York P. Crystallization of pure anhydrous polymorphs of carbamazepine by solution enhanced dispersion with supercritical fluids (SEDS). Journal of Pharmaceutical Sciences 90 (2001) 1115-1124
7. Velaga S.P., Bergh S., and Carlfors J. Stability and aerodynamic behaviour of glucocorticoid particles prepared by a supercritical fluid process. European Journal of Pharmaceutical Sciences 21 (2004) 501-509
8. Carretier E., Badens E., Guichardon P., Boutin O., and Charbit G. Hydrodynamics of supercritical antisolvent precipitation: characterization and influence on particle morphology. Industrial Engineering Chemistry Research 42 (2003) 331-338
9. Kerst A.W., Judat B., and Schlunder E.U. Flow regimes of free jets and falling films at high ambient pressure. Chemical Engineering Science 55 (2000) 4189-4208
10. W.R.J. Marshall, Atomization and Spray Drying, The American Institute of Chemical Engineers, Monographs Serie No. 2, 1954.
11. Badens E., Boutin O., and Charbit G. Laminar jet dispersion and jet atomization in pressurized carbon dioxide. The Journal of Supercritical Fluids 36 (2005) 81-90
12. Lengsfeld C.S., Delplanque J.P., Barocas V.H., and Randolph T.W. Mechanism governing microparticle morphology during precipitation by a compressed antisolvent: atomization vs nucleation and growth. Journal of Physical Chemistry B 104 (2000) 2725-2735
13. Czerwonatis N., Eggers R., and Charbit G. Disintegration of liquid jets and drop drag coefficients in pressurized nitrogen and carbon dioxide. Chemical Engineering Technology 24 (2001) 619-624
14. Dukhin S.S., Zhu C., Dave R.N., Pfeffer R., Luo J.J., Chavez F., and Shen Y. Dynamic interfacial tension near critical point of a solvent-antisolvent mixture and laminar jet stabilization. Colloids and Surfaces A 229 (2003) 181-199
15. Chavez F., Debenedetti P.G., Luo J.J., Dave R.N., and Pfeffer R. Estimation of the characteristic time scales in the supercritical antisolvent process. Industrial Engineering Chemistry Research 42 (2003) 3156-3162
16. Martin A., and Cocero M.J. Numerical modelling of jet hydrodynamics, mass transfer, and crystallization kinetics in the supercritical antisolvent (SAS) process. The Journal of Supercritical Fluids 32 (2004) 203-219
17. 2-acrylic acid. Fluid Phase Equilibria 115 (1996) 179-192
18. Chang C.J., Day C.J., Ko C.M., and Chiu K.L. Densities and P-x-y diagrams for carbon dioxide dissolution in methanol, ethanol and acetone mixtures. Fluid Phase Equilibria 131 (1997) 243-258
19. 2)-N,N-Dimethylformamide (DMF) system at temperatures from 293.95 K to 338.05 K and pressures up to 12 MPa. Journal of Chemical Engineering Data 46 (2001) 1589-1592
20. 2-alcohol systems (methanol, ethanol, 2-methoxyethanol and 2-ethoxyethanol). Fluid Phase Equilibria 185 (2001) 219-230
21. Kordikowski A., Schenk A.P., Van Nielen R.M., and Peters C.J. Volume expansions and vapor-liquid equilibria of binary mixtures of a variety of polar solvents and certain near-critical solutes. The Journal of Supercritical Fluids 8 (1995) 205-216
22. Reaves J.T., Griffith A.T., and Roberts C.B. Critical properties of dilute carbon dioxide + entrainer and ethane + entrainer mixtures. Journal of Chemical Engineering Data 43 (1998) 683-686
23. Tsivintzelis I., Missopolinou D., Kalogiannis K., and Panayiotou C. Phase compositions and saturated densities for the binary systems of carbon dioxide with ethanol and dichloromethane. Fluid Phase Equilibria 224 (2004) 89-96