Microwave-assisted synthesis and structure-activity relationships of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 1, 2010, Pages 74-77

  Nascimento Júnior, Nailton M ^a   Mendes, Thaiana C F ^a   Leal, Daniella M ^a   Corrêa, Claudia Maria N ^a   Sudo, Roberto T ^a   Zapata Sudo, Gisele ^a   Barreiro, Eliezer J ^a   Fraga, Carlos A M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Cycloaddition; Hetero Diels Alder; Microwave; Molecular simplification; Muscarinic agonists; Pyrazolo 3,4 b pyrrolo 3,4 d pyridine; Sedative agents

Indexed keywords

MIDAZOLAM; PYRAZOLO[3,4 B]PYRROLO[3,4 D]PYRIDINE DERIVATIVE; PYRIDINE DERIVATIVE; SEDATIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIELS ALDER REACTION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; LOCOMOTION; MICROWAVE IRRADIATION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; HETEROCYCLIC COMPOUNDS, 3-RING; MICE; MICROWAVES; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

ALNUS; MUS;

EID: 71949131539     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.038     Document Type: Article

References (11)

1. http://knol.google.com/k/krishan-maggon/global-brain-drugs-market-review-2008/3fy5eowy8suq3/1#
2. Korzh M. Sleep Med. 8 (2007) 578
3. Menegatti R., Silva G.M.S., Zapata-Sudo G., Raimundo J.M., Sudo R.T., Barreiro E.J., and Fraga C.A.M. Bioorg. Med. Chem. 14 (2006) 632
4. Mendes T.C.F., Raimundo J.M., Nascimento Jr. N.M., Fraga C.A.M., Barreiro E.J., and Zapata-Sudo G. Pharmacol. Biochem. Behav. 94 (2009) 70
5. Díaz-Ortiz A., Carrilo J.R., Gómez-Escalonilla M.J., de la Hoz A., Moreno A., and Prieto P. Synlett (1998) 1069
6. Díaz-Ortiz A., Carrilo J.R., Cossio F.P., Gómez-Escalonilla M.J., de la Hoz A., Moreno A., and Prieto P. Tetrahedron 56 (2000) 1569
7. Díaz-Ortiz A., de La Hoz A., and Langam F. Green Chem. 2 (2000) 165
8. Mason H.J., Wu X., Schmitt R., Macor J.E., and Yu G. Tetrahedron Lett. 42 (2001) 8931
9. Mara S., Diaz-Veliz G., Lungenstrass H., Garcia-Gonzalez M., Coto-Morales T., Poletti C., De Lima T.C.M., Herrera-Ruiz M., and Tortoriello J. J. Ethnopharmacol. 97 (2005) 191
10. Lima L.M., Barreiro E.J., and Fraga C.A.M. Synth. Commun. 30 (2000) 3291
11. Cava M.P., Deana A.A., Muth K., and Mitchell A. J. Org. Synth. Coll. 5 (1973) 944