Prospective comparison of tuberculin skin test and QuantiFERON-TB gold in-tube assay for the detection of latent tuberculosis infection among healthcare workers in a low-incidence setting

Infection Control and Hospital Epidemiology

Volumn 30, Issue 11, 2009, Pages 1123-1126

  Cummings, Kristin J ^a   Smith, Tamara S ^a   Shogren, Elizabeth S ^a   Khakoo, Rashida ^c   Nanda, Sharmilarani ^d   Bunner, Lana ^d   Smithmyer, Ann ^e   Soccorsi, Darlene ^e   Kashon, Michael L ^b   Mazurek, Gerald H ^f   Friedman, Lloyd N ^g   Weissman, David N ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b Health Effects Laboratory Division   (United States)

^c Section of Infectious Diseases   (United States)

^d WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e WEST VIRGINIA UNIVERSITY HOSPITALS   (United States)

^f CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^g YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; TUBERCULIN;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BCG VACCINATION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; EVALUATION; FEMALE; HEALTH CARE PERSONNEL; HUMAN; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; PROSPECTIVE STUDY; QUANTITATIVE ASSAY; REPRODUCIBILITY; RISK FACTOR; SCREENING TEST; SENSITIVITY AND SPECIFICITY; TUBERCULIN TEST; TUBERCULOSIS; ANALYTICAL EQUIPMENT; BLOOD; COMPARATIVE STUDY; IMMUNOLOGY; INCIDENCE; LATENT TUBERCULOSIS; METHODOLOGY; MICROBIOLOGY; MYCOBACTERIUM TUBERCULOSIS;

HEALTH PERSONNEL; HUMANS; INCIDENCE; INTERFERON-GAMMA; LATENT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; REAGENT KITS, DIAGNOSTIC; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TUBERCULIN TEST;

EID: 71949117929     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/644754     Document Type: Article

References (10)

1. Institute of Medicine (US). Committee on the Elimination of Tuberculosis in the United States. In: Geiter L, ed. Ending neglect: the elimination of tuberculosis in the United States. Washington, DC: National Academy Press; 2000.
2. Pai M, Dheda K, Cunningham J, Scano F, O'Brien R. T-cell assays for the diagnosis of latent tuberculosis infection: moving the research agenda forward. Lancet Infect Dis 2007; 7:428-438.
3. National Health Service (NHS). National Institute for Health and Clinical Excellence. Tuberculosis: clinical diagnosis and management of tuberculosis, and measures for its prevention and control. Clinical guideline 33. Developed by the National Collaborating Centre for Chronic Conditions. March 2006. Available at: http://www.nice.org.uk/page.aspx?opCG033NICEguideline. Accessed May 7, 2009.
4. Targeted tuberculin testing and treatment of latent tuberculosis infection. Am J Respir Crit Care Med 2000; 161(4 Pt 2):S221-S247.
5. Mazurek GH, Zajdowicz MJ, Hankinson AL, et al. Detection of Mycobacteriumtuberculosis infection in United States Navy recruits using the tuberculin skin test or whole-blood interferon-γ release assays. Clin Infect Dis 2007; 45:826-836.
6. Menzies D, Pai M, Comstock G. Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. Ann Intern Med 2007; 146:340-354.
7. Pai M, Riley LW, Colford JMJr. Interferon-γ assays in the immunodiagnosis of tuberculosis: a systematic review. Lancet Infect Dis 2004; 4:761-776.
8. Pollock NR, Campos-Neto A, Kashino S, et al. Discordant QuantiFERONTB Gold test results among US healthcare workers with increased risk of latent tuberculosis infection: a problem or solution? Infect Control Hosp Epidemiol 2008; 29:878-886.
9. Veerapathran A, Joshi R, Goswami K, et al. T-cell assays for tuberculosis infection: deriving cut-offs for conversions using reproducibility data. PLoS ONE 2008; 3:e1850.
10. Leyten EM, Prins C, Bossink AW, et al. Effect of tuberculin skin testing on a Mycobacterium tuberculosis-specific interferon-γ assay. Eur Respir J 2007; 29:1212-1216.